Results 181 to 190 of about 4,298 (193)
GABARAPL1 (GEC1) associates with autophagic vesicles [PDF]
Autophagy, 2010 Gabarapl1 (gec1) was first described as an estrogen regulated gene which shares a high sequence homology with the gabarap gene. We previously demonstrated that GABARAPL1, like GABARAP, interacts with the GABAA receptor and tubulin and promotes tubulin polymerization.
annick fraichard, Régis Delage-Mourroux
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GABARAPL1 is required for increased EGFR membrane expression during hypoxia
Radiotherapy and Oncology, 2015The epidermal growth factor receptor (EGFR) is overexpressed, amplified or mutated in various human epithelial tumors and hypoxia is a common feature of solid tumors. Both EGFR and hypoxia are associated with therapy resistance and poor treatment outcome.
Marc A Vooijs +2 more
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The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models [PDF]
BMC Cancer, 2015 The GABARAP family members (GABARAP, GABARAPL1/GEC1 and GABARAPL2 /GATE-16) are involved in the intracellular transport of receptors and the autophagy pathway. We previously reported that GABARAPL1 expression was frequently downregulated in cancer cells while a high GABARAPL1 expression is a good prognosis marker for patients with lymph node-positive ...
Eric Hervouet +2 more
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The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells [PDF]
Autophagy, 2014 GABARAPL1/GEC1 is an early estrogen-induced gene which encodes a protein highly conserved from C. elegans to humans. Overexpressed GABARAPL1 interacts with GABAA or kappa opioid receptors, associates with autophagic vesicles, and inhibits breast cancer cell proliferation.
annick fraichard +2 more
exaly +4 more sources
Molecular Brain Research, 2003
GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons.
Christophe, Nemos +5 more
openaire +2 more sources
GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons.
Christophe, Nemos +5 more
openaire +2 more sources
Xenotransplantation, 2019
AbstractAfter hyperacute rejection in pig‐to‐primate xenotransplantation had been overcome by the introduction of α1,3‐galactosyltransferase gene‐knockout (GTKO) pigs, acute and chronic antibody‐mediated rejection became one of the major barriers to long‐term graft survival.
Hidetaka Hara, Xiliang Wang, Dengke Pan
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AbstractAfter hyperacute rejection in pig‐to‐primate xenotransplantation had been overcome by the introduction of α1,3‐galactosyltransferase gene‐knockout (GTKO) pigs, acute and chronic antibody‐mediated rejection became one of the major barriers to long‐term graft survival.
Hidetaka Hara, Xiliang Wang, Dengke Pan
exaly +3 more sources
High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer [PDF]
British Journal of Cancer, 2010 This study evaluates the relation of the early oestrogen-regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma.First, the relation between GABARAPL1 expression and MCF-7 growth rate was analysed. Thereafter, by performing macroarray and reverse transcriptase quantitative-polymerase chain reaction (RT-qPCR)
Alexandre Berthier +1 more
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International Journal of Biological Macromolecules
Eosinophils play a featured role among inflammatory cells participating in the onset and development of asthma. Activated eosinophils release several cytotoxic granular proteins, such as major basic protein (MBP), posing a significant threat to airway epithelium.
Xiaojun Zha
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Eosinophils play a featured role among inflammatory cells participating in the onset and development of asthma. Activated eosinophils release several cytotoxic granular proteins, such as major basic protein (MBP), posing a significant threat to airway epithelium.
Xiaojun Zha
exaly +3 more sources
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2005
The gec1/GABARAPL1 (GABA(A)-receptor-associated protein like-1) gene has been identified as an early estrogen-regulated gene in guinea-pig cultured endometrial glandular epithelial cells (GEC). Guinea-pig and human gec1/GABARAPL1 proteins share 87% identity with GABARAP, which acts as a protein linker between microtubules and the GABA(A) receptor.
Sandrine, Vernier-Magnin +7 more
openaire +2 more sources
The gec1/GABARAPL1 (GABA(A)-receptor-associated protein like-1) gene has been identified as an early estrogen-regulated gene in guinea-pig cultured endometrial glandular epithelial cells (GEC). Guinea-pig and human gec1/GABARAPL1 proteins share 87% identity with GABARAP, which acts as a protein linker between microtubules and the GABA(A) receptor.
Sandrine, Vernier-Magnin +7 more
openaire +2 more sources
The NMD Pathway Regulates GABARAPL1 mRNA during the EMT
Biomedicines, 2021Stefania Millevoi +2 more
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