Results 131 to 140 of about 4,821 (166)

Negative Regulation of GADD34 on Myofibroblasts during Cutaneous Wound Healing

Negative Regulation of GADD34 on Myofibroblasts during Cutaneous Wound Healing
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Gadd34 Functional Domains Involved in Growth Suppression and Apoptosis [PDF]

Oncogene, 2003
Gadd34 (also known as MyD116) was originally described as a growth arrest and DNA damage-inducible gene. Increased expression of Gadd34 was subsequently found to correlate with apoptosis, and forced overexpression of the protein leads to apoptosis. Gadd34 protein modulates protein phosphatase type 1 activity through both direct binding to the protein ...
Albert J Fornace, M Christine Hollander
exaly   +3 more sources

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GADD34 Induces p53 Phosphorylation and p21/WAF1 Transcription

Journal of Cellular Biochemistry, 2003
AbstractRecently, others and we have shown that one of the functions of GADD34 is a recovery from a shutoff of protein synthesis induced by endoplasmic reticulum stress. GADD34 has been shown to induce growth arrest and apoptosis. Main protein of apoptosis is p53, especially phosphorylation of p53.
Akihiko Nishikimi, Ken-ichi Isobe, Yoshinori Hasegawa   +2 more
exaly   +3 more sources

Phosphorylation at Tyrosine 262 Promotes GADD34 Protein Turnover [PDF]

Journal of Biological Chemistry, 2013
In mammalian cells, metabolic and environmental stress increases the phosphorylation of the eukaryotic translational initiation factor, eIF2α, and attenuates global protein synthesis. Subsequent transcriptional activation of GADD34 assembles an eIF2α phosphatase that feeds back to restore mRNA translation.
Wei Zhou, Shirish Shenolikar
exaly   +3 more sources

Increased GADD34 in Oligodendrocytes in Alzheimer’s Disease

Neuroscience Letters, 2015
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) and abnormally phosphorylated tau which contribute to endoplasmic reticulum (ER) stress. Previous studies demonstrated that Aβ and a truncated fragment of Aβ induced death of oligodendrocytes in vitro.
Ryosuke Takahashi, Hidefumi Ito, Koji Kawakami   +2 more
exaly   +3 more sources

Evidence for the Interaction Between Translin and GADD34 in Mammalian Cells

Biochimica Et Biophysica Acta - General Subjects, 1999
To examine the function of GADD34, we used the yeast two-hybrid system to clone the protein that interacts with the murine GADD34 gene product. We utilized, as bait, the product of the GADD34 cDNA deletions including the PEST region and the gamma(1)34.5 domain.
Ken-ichi Isobe, Tadao Hasegawa
exaly   +3 more sources

Role of GADD34 in modulation of cisplatin cytotoxicity

Biochemical Pharmacology, 2006
Cisplatin and carboplatin are widely used clinical chemotherapeutic agents, especially against testicular, ovarian, and head and neck cancers. O(6)-Benzylguanine (BG) has been shown to result in enhanced cytotoxicity, apoptosis, and DNA platination when used in conjunction with cisplatin and carboplatin in head and neck cancer cell lines.
Melissa L, Fishel, Cara A, Rabik, Wasim K, Bleibel, Xinmin, Li, Robert C, Moschel, M Eileen, Dolan   +5 more
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Interaction between GADD34 and Kinesin Superfamily, KIF3A

Biochemical and Biophysical Research Communications, 2000
GADD34 is one of a subset of proteins induced after DNA damage or cell growth arrest. To examine the function of GADD34, we used the yeast two-hybrid system to clone the protein that interacts with the murine GADD34. One cDNA clone was the C-terminal part of KIF3A gene including the tail domain. The interaction between GADD34 and KIF3A was confirmed in
T, Hasegawa, A, Yagi, K, Isobe
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Quercetin reduces eIF2α phosphorylation by GADD34 induction

Neurobiology of Aging, 2015
The production of amyloid β (Aβ) in the brain from Aβ precursor protein (APP) through γ-secretase is important for the pathogenesis of Alzheimer's disease (AD). Our previous studies have demonstrated that autophagy impairment and endoplasmic reticulum stress increase presenilin 1 expression and enhance γ-secretase activity through the phosphorylation ...
Miki, Hayakawa, Masanori, Itoh, Kazunori, Ohta, Shimo, Li, Masashi, Ueda, Miao-xing, Wang, Emika, Nishida, Saiful, Islam, Chihiro, Suzuki, Kaori, Ohzawa, Masuko, Kobori, Takashi, Inuzuka, Toshiyuki, Nakagawa   +12 more
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The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress—elucidation by GADD34‐deficient mice

The FASEB Journal, 2003
ABSTRACT GADD34 is a protein that is induced by stresses such as DNA damage. The function of mammalian GADD34 has been proposed by in vitro transfection, but its function in vivo has not yet been elucidated.
Eiji, Kojima, Akihide, Takeuchi, Masataka, Haneda, Ayako, Yagi, Tadao, Hasegawa, Ken-ichi, Yamaki, Kiyoshi, Takeda, Shizuo, Akira, Kaoru, Shimokata, Ken-ichi, Isobe   +9 more
openaire   +2 more sources