Results 141 to 150 of about 4,821 (166)

Evolution of GADD34 expression after focal cerebral ischaemia

Brain Research, 2005
GADD34, a stress response protein associated with cell rescue, DNA repair and apoptosis, is expressed in the ischaemic brain. The C-terminal region of GADD34 has homology with the Herpes Simplex Virus protein, ICP34.5, which overcomes the protein synthesis block after viral infection by actively dephosphorylating eukaryotic translation initiation ...
David, McCaig, Hideaki, Imai, Lindsay, Gallagher, David I, Graham, June, Harland, S, Moira Brown, I, Mhairi Macrae   +6 more
openaire   +2 more sources

Increased Expression of GADD34 in Ovarian Carcinomas

Korean Journal of Gynecologic Oncology and Colposcopy, 2004
Objective : GADD34 was originally described as a growth arrest and DNA damage-inducible gene. Increased expression of GADD34 was subsequently found to correalate with apoptosis, and forced overexpression of the protein leads to apoptosis. In this study we evaluated the expression of GADD34 in ovarian cancers and normal ovarian tissues.
Won kyung Shon, Chi Heum Cho, Dae Kyu Song, Sang Hoon Kwon, Sook Hyun Kim, Hyoung Ok Kang, Soon Do Cha   +6 more
openaire   +1 more source

Gadd34 Induces Autophagy Through the Suppression of the mTOR Pathway During Starvation

Biochemical and Biophysical Research Communications, 2011
Several types of cellular stress induce expression of growth arrest and DNA damage protein 34 (Gadd34). Autophagy occurs under both basal conditions and conditions of stress, such as starvation. Gadd34 and autophagy are both induced under starvation conditions.
Ken-ichi Isobe, Naomi Nishio
exaly   +3 more sources

Female GADD34 Mice Develop Age-Related Inflammation and Hepatocellular Carcinoma

Geriatrics and Gerontology International, 2017
AimTo analyze the impact of sex on GADD34 function, we studied the aging of female GADD34‐deficient mice and compared them with male GADD34‐deficient mice.MethodsWe used GADD34‐deficient mice on a C57BL/6 background. These mice were fed a normal diet throughout their life. Alternatively, they were fed a high‐fat diet at 3 months‐of‐age.
Ken-Ichi Isobe, Ichiro Tatsuno, Masanori Isaka   +2 more
exaly   +3 more sources

GADD34 suppresses wound healing by upregulating expression of myosin IIA

Transgenic Research, 2009
Wound healing consists of sequential steps of tissue repair, and cell migration is particularly important. In order to analyze the potential function of growth arrest and DNA damage inducible protein 34 (GADD34) in tissue repair, we performed in vitro and in vivo wound healing experiments.
Chie, Tanaka, Sachiko, Ito, Naomi, Nishio, Yasuhiro, Kodera, Hidetoshi, Sakurai, Haruhiko, Suzuki, Akimasa, Nakao, Ken-Ichi, Isobe   +7 more
openaire   +2 more sources

Linking stress granulopoiesis to protein synthesis through GADD34

Immunology & Cell Biology, 2014
In the current issue, Nishio et al.1 propose a novel role for the growth arrest and DNA damage inducible 34 (GADD34) in the suppression of myelopoiesis and stress granulopoiesis. They observed that older Gadd34−/− mice displayed an increase in both immature (Gr1low CD11b+) and mature granulocytes (Gr1hi CD11b+).
Hrishikesh M Mehta, Seth J Corey
openaire   +1 more source

Loss of GADD34 induces early age‐dependent deviation to the myeloid lineage

Immunology & Cell Biology, 2013
Hematopoietic stem cells (HSCs) generate all known hematopoietic lineages and are capable of self‐renewal. Upon aging, myeloid‐biased HSCs are maintained, whereas lymphoid‐biased HSCs are lost. GADD34 protein is expressed in myeloid‐lineage cells and has been cloned from them.
Naomi, Nishio, Sachiko, Ito, Ken-ichi, Isobe   +2 more
openaire   +2 more sources

Role of GADD34 in age‐related differences in hyperoxiainduced stress signaling

The FASEB Journal, 2013
Hyperoxic exposure activates an adaptive signal transduction pathway in the lung known as the integrated stress response (ISR), which promotes the expression of factors that modulate redox balance, the immune response, and DNA repair. Given that newborns (NB) are more tolerant to the toxic effects of O 2
Jeffrey Shenberger, Yuchieh Melissa Wu
openaire   +1 more source

GADD34 Facilitates Cell Death Resulting from Proteasome Inhibition.

Anticancer research, 2016
Proteasome inhibition has been proven to be a promising therapeutic strategy in cancer clinical treatment. Inhibition of proteasome leads to failure of amino acid homeostasis, which causes cell death via activation of various mechanisms.To investigate the role of GADD34 in cell death following proteasome inhibition, we treated WT MEF and GADD34 KO MEF ...
Lintao, Liu, Sachiko, Ito, Naomi, Nishio, Yang, Sun, Nana, Chen, Yuriko, Tanaka, Ken-Ichi, Isobe   +6 more
openaire   +1 more source

Growth Arrest and DNA Damage-Inducible Protein 34 (GADD34) Contributes to Cerebral Ischemic Injury and Can Be Detected in Plasma Exosomes

Neuroscience Letters, 2021
Liang Zhao, Peng Wang
exaly