Results 21 to 30 of about 329,144 (235)

Effects of reduced gag cleavage efficiency on HIV-1 Gag-Pol package

BMC Microbiology, 2022
Background HIV-1 pol, which encodes enzymes required for virus replication, is initially translated as a Gag-Pol fusion protein. Gag-Pol is incorporated into virions via interactions with Gag precursor Pr55 gag .
Yi-Ru Lin, Shih-Ming Chu, Fu-Hsien Yu, Kuo-Jung Huang, Chin-Tien Wang   +4 more
doaj   +1 more source

Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells. [PDF]

PLoS ONE, 2012
A safe and effective HIV vaccine is required to significantly reduce the number of people becoming infected with HIV each year. In this study wild type Mycobacterium bovis BCG Pasteur and an attenuated pantothenate auxotroph strain (BCGΔpanCD) that is ...
Rosamund Chapman, Enid Shephard, Helen Stutz, Nicola Douglass, Vasan Sambandamurthy, Irene Garcia, Bernhard Ryffel, William Jacobs, Anna-Lise Williamson   +8 more
doaj   +1 more source

Delivering the second revolution in site-specific nucleases

eLife, 2014
Viruses have been used to deliver two types of site-specific nucleases into cells for targeted gene editing.
Perry B Hackett, Nikunj V Somia
doaj   +1 more source

HIV protein profile characteristics in patients with first-time detected infection

Инфекция и иммунитет
The HIV-infection continues to be one of the most large-scale epidemics worldwide. Many techniques have been developed to detect this disease, but the Western blot based on the identification of specific viral proteins remains the most commonly used ...
V. S. Davydenko, Yuliia V. Ostankova, A. N. Schemelev, E. N. Serikova, A. A. Totolian   +4 more
doaj   +1 more source

Characterization of low level viraemia in HIV-infected patients receiving boosted protease inhibitor-based antiretroviral regimens

HIV Research & Clinical Practice, 2019
To understand the pathogenesis of low level viraemia (LLV) in HIV-infected patients on boosted protease inhibitors (PI/b), we enrolled 34 subjects with a median HIV-RNA 79 copies/mL and followed them for 15 months.
Francesca Ferretti, Nicola E. Mackie, Gurmit Kaur Jagjit Singh, Julie Fox, Steve Kaye, Myra O. McClure, Graham Taylor, Marta Boffito   +7 more
doaj   +1 more source

HIV Pol inhibits HIV budding and mediates the severe budding defect of Gag-Pol. [PDF]

PLoS ONE, 2012
The prevailing hypothesis of HIV budding posits that the viral Gag protein drives budding, and that the Gag p6 peptide plays an essential role by recruiting host-cell budding factors to sites of HIV assembly. HIV also expresses a second Gag protein, p160
Xin Gan, Stephen J Gould
doaj   +1 more source

Plasma Membrane Anchoring and Gag:Gag Multimerization on Viral RNA Are Critical Properties of HIV-1 Gag Required To Mediate Efficient Genome Packaging

mBio, 2021
Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA.
Alice Duchon, Steven Santos, Jianbo Chen, Matthew Brown, Olga A. Nikolaitchik, Sheldon Tai, Jeffrey A. Chao, Eric O. Freed, Vinay K. Pathak, Wei-Shau Hu   +9 more
doaj   +1 more source

A novel minimal in vitro system for analyzing HIV-1 Gag mediated budding

, 2014
A biomimetic minimalist model membrane was used to study the mechanism and kinetics of cell-free in vitro HIV-1 Gag budding from a giant unilamellar vesicle (GUV).
Gill, Sarjeet, Gui, Dong, Gupta, Sharad, Huang, I-Chueh, Mohideen, Umar, Rao, A. L. N., Xu, Jun, Zandi, Roya   +7 more
core   +1 more source

A New Linear B Inscription from the Land Down Under: AUS HO(ME) Bo 2008 [PDF]

, 2008
Gag paper on a fictitious Linear B boomerang, given at the 12th International Aegean Conference held in Melbourne ...
Palaima, Thomas G.
core   +1 more source

Baboon endogenous virus genome: Molecular cloning and structural characterization of nondefective viral genomes from DNA of a baboon cell strain [PDF]

, 1981
Several heterogeneities in the baboon endogenous virus (BaEV) genomes that are present in the DNA of normal baboon tissues and the baboon cell strain BEF-3 have been described previously.
Cohen, Maurice, Davidson, Norman, Gilden, Raymond V., McAllister, Robert M., Nicolson, Margery O., O'Connell, Catherine, Rein, Alan, Shure, Mavis, Stephens, Robert M.   +8 more
core   +1 more source