Results 11 to 20 of about 43,371 (254)

Galactosamine Hepatitis, Endotoxemia, and Lactulose [PDF]

Hepatology, 1983
Studies by Liehr et al. suggest that endotoxins are important in the pathogenesis of galactosamine hepatitis (Gal–N hepatitis) in rats. Lactulose (9.1 gm per kg per day) prevents hepatic lesions induced by Gal–N; an antiendotoxin effect of lactulose is postulated.
Hendrina van Vugt, J. van Gool, Lambert L.M. Thomas   +2 more
openalex   +3 more sources

Crosstalk of TNF-α, IFN-γ, NF-kB, STAT1 and redox signaling in lipopolysaccharide/d-galactosamine/dimethylsulfoxide-induced fulminant hepatic failure in mice

Saudi Pharmaceutical Journal, 2023
Purpose: The clinical study of fulminant hepatic failure is challenging due to its high mortality and relative rarity, necessitating reliance on pre-clinical models to gain insight into its pathophysiology and develop potential therapies.
Abdulrazaq Alanazi, Mahmoud N. Nagi, Dhafer Y. Alhareth, Mohammed A Al-Hamamah, Mohamed A Mahmoud, Sheikh F. Ahmad, Mushtaq A. Ansari, Ahmed Nadeem, Saleh A. Bakheet, Gamaleldin I. Harisa, Sabry M. Attia   +10 more
doaj   +1 more source

Quantitative Analysis of Impurities in Unfractionated Heparin of Bovine Origin

Frontiers in Medicine, 2020
The USP heparin sodium monograph lists impurities with specifications developed for porcine derived products. Most of these impurities are of biological origin and are present in porcine intestinal mucosa, the tissue source used in the production of ...
Wesley E. Workman, Kevin L. Carrick
doaj   +1 more source

Therapeutic Efficacy and Safety Profile of Eplontersen in Hereditary Transthyretin-Mediated Amyloidosis: A Systematic Review. [PDF]

Health Sci Rep
ABSTRACT Background Hereditary transthyretin‐mediated amyloidosis (hATTR) is a disorder that affects several body systems and can result in life‐threatening conditions like cardiomyopathy and polyneuropathy. For treatment of hATTR in the new medical realm, there is a breakthrough discovery of a medicine called Eplontersen, which targets the underlying ...
Patel ZV, Kumari V, Paras, Deepak BL, Prajjwal P, Deep KN, Bai R, John SS, Hussin OA.   +8 more
europepmc   +2 more sources

Assembly of a Library of Pel-Oligosaccharides Featuring α-Glucosamine and α-Galactosamine Linkages

Frontiers in Chemistry, 2022
Pseudomonas aeruginosa, a pathogenic Gram-negative bacterium for which currently antibiotic resistance is posing a significant problem and for which no vaccines are available, protects itself by the formation of a biofilm.
Yongzhen Zhang, Liming Wang, Liming Wang, Herman S. Overkleeft, Gijsbert A. van der Marel, Jeroen D. C. Codée   +5 more
doaj   +1 more source

Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine [PDF]

Acta Cirúrgica Brasileira, 2016
PURPOSE: To describe an animal model for acute liver failure by intraperitoneal d-galactosamine injections in rats and to define when is the best time to intervene through King's College and Clichy´s criteria evaluation.
Lígia Patrícia de Carvalho Batista Éboli, Alcides Augusto Salzedas Netto, Ramiro Antero de Azevedo, Valéria Pereira Lanzoni, Tatiana Sugayama de Paula, Alberto Goldenberg, Adriano Miziara Gonzalez   +6 more
doaj   +1 more source

Electric Method for the Desulfation of Polysaccharides From Red Microalgae (Porphyridium cruentum) Cultures. [PDF]

Biopolymers
A non‐destructive method for depleting sulfates from the red microalgae Porphyridium cruentum by directly exposing the growth medium to a moderate electric field has been developed. The reported electric‐field separation method is a simple, straightforward, and non‐toxic means for the direct recovery of desulfated polysaccharides from P.
Levy-Ontman O, Bar-Gil A, Shemesh E, Huliehel M, Amor Y, Landes N, Sadeh Y, Tchernov D.   +7 more
europepmc   +2 more sources

Studies of liver phosphorylase in hepatic injuries. I. Alteration in enzyme activity [PDF]

, 1978
Phosphorylase activities (total and a form) were determined in the livers of experimental hepatic injuries with carbon tetrachloride or galactosamine and the livers of patients with liver diseases.
Kobayashi, Michio
core   +1 more source

Targeted Sterically Stabilized Phospholipid siRNA Nanomedicine for Hepatic and Renal Fibrosis

Nanomaterials, 2016
Since its discovery, small interfering RNA (siRNA) has been considered a potent tool for modulating gene expression. It has the ability to specifically target proteins via selective degradation of messenger RNA (mRNA) not easily accessed by conventional ...
Fatima Khaja, Dulari Jayawardena, Antonina Kuzmis, Hayat Önyüksel   +3 more
doaj   +1 more source

Possible Association Between DHEA and PKCε in Hepatic Encephalopathy Amelioration: A Pilot Study

Frontiers in Veterinary Science, 2021
Objective: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome caused by liver failure and by an impaired neurotransmission and neurological function caused by hyperammonemia (HA).
Alessandro Di Cerbo, Luca Roncati, Carlotta Marini, Gianluca Carnevale, Manuela Zavatti, Rossella Avallone, Lorenzo Corsi, Lorenzo Corsi   +7 more
doaj   +1 more source