Results 21 to 30 of about 26,061 (186)

Phosphorylation of eIF2α mitigates endoplasmic reticulum stress and hepatocyte necroptosis in acute liver injury

Annals of Hepatology, 2020
Introduction and objectives: Necroptosis and endoplasmic reticulum (ER) stress has been implicated in acute and chronic liver injury. Activated eukaryotic initiation factor 2 alpha (eIF2α) attenuates protein synthesis and relieves the load of protein ...
Ren-Dong Tian, Yi-Qun Chen, Yi-Huai He, Yong-Jing Tang, Gui-Mei Chen, Fang-Wan Yang, Ying Li, Wen-Ge Huang, Huan Chen, Xia Liu, Shi-De Lin   +10 more
doaj   +1 more source

Succinate dehydrogenase inhibitor dimethyl malonate alleviates LPS/-galactosamine-induced acute hepatic damage in mice

Innate Immunity, 2019
In addition to its energy-supplying function, increasing evidence suggests that mitochondria also play crucial roles in the regulation of inflammation.
Yongqiang Yang, Ruyue Shao, Li Tang, Longjiang Li, Min Zhu, Jiayi Huang, Yi Shen, Li Zhang   +7 more
doaj   +1 more source

Definition of the Anti-inflammatory Oligosaccharides Derived From the Galactosaminogalactan (GAG) From Aspergillus fumigatus

Frontiers in Cellular and Infection Microbiology, 2019
Galactosaminogalactan (GAG) is an insoluble aminosugar polymer produced by Aspergillus fumigatus and has anti-inflammatory properties. Here, the minimum glycosidic sequences required for the induction of IL-1Ra by peripheral blood mononuclear cells ...
Markus Gressler, Christoph Heddergott, Inés C. N'Go, Giorgia Renga, Vasilis Oikonomou, Silvia Moretti, Bernadette Coddeville, Joana Gaifem, Joana Gaifem, Ricardo Silvestre, Ricardo Silvestre, Luigina Romani, Jean-Paul Latgé, Thierry Fontaine   +13 more
doaj   +1 more source

Paper chromatographic separation of glucosamine and galactosamine [PDF]

Analytical Biochemistry, 1964
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/32118/1/0000168 ...
Mukerjee, H., Sri Ram, J.
openaire   +3 more sources

Correlation between synthesis of α2-macroglobulin as acute phase protein and degree of hepatopathy in rats

Laboratory Animal Research, 2019
The degree of hepatopathy affecting the synthesis of α2-macroglobulin (α2M) as an acute phase protein in rats was investigated. Hepatopathy was induced in Sprague-Dawley rats by intravenous administration of galactosamine at a dose of 30 mg/kg for 7 days.
Reina Ito, Takashi Kuribayashi
doaj   +1 more source

Galactosamine in walls of slow-growing mycobacteria [PDF]

Biochemical Journal, 1997
Galactosamine was found consistently as a minor component of the envelope of five species of slow-growing mycobacteria, including all the major human pathogens, but not three rapid-growing species. The amino sugar was a component of the arabinogalactan of the cell wall skeleton, and occurred at the level of about one residue per arabinogalactan chain ...
P, Draper, K H, Khoo, D, Chatterjee, A, Dell, H R, Morris   +4 more
openaire   +2 more sources

Effect of Lochein on liver metabolism under acute intoxication caused by the paracetamol and D-galactosamine

Бюллетень сибирской медицины, 2006
Influence of original hepatoprotector lochein in comparison with influence of reference drug silimarin on metabolism of liver under acute intoxication caused in rats by the paracetamol or D -galactosamine was investigated in the given study.
A. N. Sokolovskaya
doaj   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

Synthesis and in vitro cytotoxicity of acetylated 3-fluoro, 4-fluoro and 3,4-difluoro analogs of D-glucosamine and D-galactosamine

Beilstein Journal of Organic Chemistry, 2016
Background: Derivatives of D-glucosamine and D-galactosamine represent an important family of the cell surface glycan components and their fluorinated analogs found use as metabolic inhibitors of complex glycan biosynthesis, or as probes for the study of
Štěpán Horník, Lucie Červenková Šťastná, Petra Cuřínová, Jan Sýkora, Kateřina Káňová, Roman Hrstka, Ivana Císařová, Martin Dračínský, Jindřich Karban   +8 more
doaj   +1 more source

High density lipoprotein subpopulations from galactosamine-treated rats and their transformation by lecithin:cholesterol acyltransferase

Journal of Lipid Research, 1991
It is known that an acute hepatotoxicity is produced in rats by intraperitoneal administration of galactosamine; a consequence of this treatment is a marked deficiency of lecithin:cholesterol acyltransferase (LCAT) activity in the plasma compartment.
JE Matsuura, JB Swaney
doaj   +1 more source