Galactosamine Hepatitis, Endotoxemia, and Lactulose [PDF]
Hepatology, 1983 Studies by Liehr et al. suggest that endotoxins are important in the pathogenesis of galactosamine hepatitis (Gal–N hepatitis) in rats. Lactulose (9.1 gm per kg per day) prevents hepatic lesions induced by Gal–N; an antiendotoxin effect of lactulose is postulated.
H, van Vugt, J, van Gool, L L, Thomas
openaire +2 more sources
Role of CD44 and its v7 isoform in staphylococcal enterotoxin B-induced toxic shock : CD44 deficiency on hepatic mononuclear cells leads to reduced activation-induced apoptosis that results in increased liver damage [PDF]
, 2005 Exposure to bacterial superantigens such as staphylococcal enterotoxin B (SEB) leads to the induction of toxic shock syndrome which results in multiorgan failure, including liver damage.
McKallip, R. J. +5 more
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Targeted Sterically Stabilized Phospholipid siRNA Nanomedicine for Hepatic and Renal Fibrosis
Nanomaterials, 2016 Since its discovery, small interfering RNA (siRNA) has been considered a potent tool for modulating gene expression. It has the ability to specifically target proteins via selective degradation of messenger RNA (mRNA) not easily accessed by conventional ...
Fatima Khaja +3 more
doaj +1 more source
Possible Association Between DHEA and PKCε in Hepatic Encephalopathy Amelioration: A Pilot Study
Frontiers in Veterinary Science, 2021 Objective: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome caused by liver failure and by an impaired neurotransmission and neurological function caused by hyperammonemia (HA).
Alessandro Di Cerbo +7 more
doaj +1 more source
The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury. [PDF]
, 2010 The pregnane X receptor (PXR) is a nuclear receptor transcription factor regulating drug-metabolizing enzymes and transporters that facilitate xenobiotic and endobiotic detoxification.
Damjanov, Ivan +2 more
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Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection [PDF]
, 2018 This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827 ...
Gow, Neil A R +5 more
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A novel technique for selective NF-kappa B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion. [PDF]
, 2009 Background and aims: The transcription factor nuclear factor kappa B (NF-kB) has risen as a promising target for anti-inflammatory therapeutics. In the liver, however, NFkB inhibition mediates both damaging and protective effects.
A. Hartkorn +11 more
core +1 more source
Problems in Treating Experimentally Induced Acute Hepatic Failure by Hemoperfusion or Cross Circulation [PDF]
, 1983 Acute hepatic failure was induced in rats by galactosamine injection intraperitoneally (1 gm per kg). Twenty-four hours later rats were treated by hemoperfusion (HP) over encapsulated sorbents: cellulose acetate-coated charcoal, polyelectrolyte-coated ...
Beyerbacht, Ellen C. +3 more
core +6 more sources
The Ensemble of Conformations of Antifreeze Glycoproteins (AFGP8): A Study Using Nuclear Magnetic Resonance Spectroscopy. [PDF]
, 2019 The primary sequence of antifreeze glycoproteins (AFGPs) is highly degenerate, consisting of multiple repeats of the same tripeptide, Ala-Ala-Thr*, in which Thr* is a glycosylated threonine with the disaccharide beta-d-galactosyl-(1,3)-alpha-N-acetyl-d ...
Her, Cheenou +2 more
core +1 more source
Journal of Pharmacy and Bioallied Sciences, 2015 Objective: The present study was envisaged to evaluate the protective effect of polyherbal formulation, DRDC/AY/8060, developed by Dabur India Ltd., against paracetamol and D-galactosamine induced hepatic toxicities in Wistar rats. Materials and Methods:
Mohammad Ahmed Khan +4 more
doaj +1 more source