Results 51 to 60 of about 43,371 (254)
Hepatoprotective effect of pentoxifylline against D-galactosamine-induced hepatotoxicity in rats
Annals of Hepatology, 2009 The present study was conducted to investigate effect of pentoxifylline (PTX) on acute liver injury caused by galactosamine (D-Gal) in rats and the underlying mechanism involved in this setting.
Ashraf Taye +4 more
doaj +1 more source
MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock [PDF]
, 2014 Background: MAPK-activated protein kinase 2 (MK2) plays a pivotal role in the cell response to (inflammatory) stress. Among others, MK2 is known to be involved in the regulation of cytokine mRNA metabolism and regulation of actin cytoskeleton dynamics ...
Vandendriessche, Benjamin +5 more
core +1 more source
Interactions of Mucus Monosaccharides and the Epidermal Microbiome in Four Benthic Elasmobranchs
Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.Here we collected mucus and microbes from the skin of Elasmobranchs to identify interactions between mucus and the microbial community. We identified key microbial genes involved in the metabolism of mucus carbohydrates in Elasmobranchs. ABSTRACT Epidermal mucus is a complicated mixture of macromolecules which acts as the first line of defence for ...
Emma N. Kerr +8 more
wiley +1 more source
Enzymic phosphorylation of galactosamine and galactose [PDF]
Archives of Biochemistry and Biophysics, 1953 Abstract The transfer of phosphate from adenosine triphosphate to galactosamine was found to be catalyzed by a liver enzyme. On the basis of the parallel distribution and from crossed inhibition experiments, it is suggested that the enzyme may be galactokinase. The optimum conditions for activity and a method for partial purification are described.
Cardini, Carlos E. +1 more
openaire +3 more sources
Cell Transplantation, 2009 Efficient repopulation by transplanted hepatocytes in the severely injured liver is essential for their clinical application in the treatment of acute hepatic failure.
Chun-Hsien Yu +5 more
doaj +1 more source
Downregulation of Tumor Necrosis Factor Expression in the Human Mono-Mac-6 Cell Line [PDF]
, 1989 Mono-Mac-6 cells, but not U937 cells, can be Induced to rapidly express tumor necrosis factor (TNF) mRNA and protein when triggered with Ilpopolysaccharlde (LPS) at 1 pg/mI. Preincubatlon of the cells for 3 d with low amounts of LPS (10 ng/mI) results In
Blömer, Kathi +5 more
core +1 more source
Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease
Advanced Materials, Volume 38, Issue 17, 20 March 2026.RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley +1 more source
The Model of D-Galactosamine-Induced Injury of Rat Hepatocytes in Primary Culture
Acta Medica, 2006 D-galactosamine (GalN) is a highly selective hepatotoxin that causes liver damage similar to human viral hepatitis via depletion of uridine nucleotides, which subsequently diminishes synthesis of RNA and proteins. Model of galactosamine hepatotoxicity is
Otto Kučera +5 more
doaj +1 more source
Detection of inflammation- and neoplasia-associated alterations in human large intestine using plant/invertebrate lectins, galectin-1 and neoglycoproteins [PDF]
, 1998 Commonly, plant and invertebrate lectins are accepted glycohistochemical tools for the analysis of normal and altered structures of glycans in histology and pathology.
Bosbach, R. +3 more
core +1 more source
Aggregate, Volume 7, Issue 3, March 2026.A precise dual‐targeting covalent organic framework (COF) nanoplatform that avoids aggregation‐caused quenching (ACQ) to achieve synergistic high‐efficiency Type I photodynamic therapy and chemotherapy. ABSTRACT There is an urgent need to develop innovative therapeutic strategies for hepatocellular carcinoma (HCC) treatment with severe hypoxia ...
Xiang Wang +9 more
wiley +1 more source