Results 71 to 80 of about 41,097 (233)

M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes. [PDF]

, 2017
Acute injury in the setting of liver fibrosis is an interesting and still unsettled issue. Most recently, several prominent studies have indicated the favourable effects of liver fibrosis against acute insults.
Bai, Li, Chen, Yu, Duan, Zhongping, Han, Yuan-Ping, Hu, Richard, Kong, Ming, Liu, Shuang, Liu, Xin, Lou, Jinli, Pandol, Stephen J, Ren, Feng, Zhang, Xiaohui, Zheng, Qingfen, Zheng, Sujun   +13 more
core   +2 more sources

OMICS Profiling Identifies Signatures of Senescence in Osteogenesis Imperfecta Osteoblasts Counteracted by 4‐PBA

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Mutations in collagen I are the most common cause of osteogenesis imperfecta (OI), leading to delayed protein folding and structurally abnormal molecules. While some aberrant collagen is secreted into the extracellular matrix (ECM), impairing bone quality, a significant fraction is retained intracellularly, disrupting osteoblast homeostasis. 4‐
Roberta Besio, Elisa Maffioli, Erika Palladino, Alessandra Sala, Nadia Garibaldi, Valerio Izzi, Antonella Forlino, Gabriella Tedeschi   +7 more
wiley   +1 more source

The Protection of Midazolam Against Immune Mediated Liver Injury Induced by Lipopolysaccharide and Galactosamine in Mice

Frontiers in Pharmacology, 2019
Objectives: Liver macrophages agitated by Lipopolysaccharide (LPS) can enhance immuno-inflammatory responses in the liver which mediate liver injury and result in dysfunction.
Jian Li, Jian Li, Jian Li, Hong Tan, Hong Tan, Xiaona Zhou, Xiaona Zhou, Chunpan Zhang, Chunpan Zhang, Chunpan Zhang, Hua Jin, Hua Jin, Hua Jin, Yue Tian, Yue Tian, Yue Tian, Xinyan Zhao, Xinyan Zhao, Xinmin Li, Xinmin Li, Xinmin Li, Xuelian Sun, Xuelian Sun, Meili Duan, Meili Duan, Meili Duan, Dong Zhang, Dong Zhang, Dong Zhang, Dong Zhang   +29 more
doaj   +1 more source

Luzindole attenuates LPS/-galactosamine-induced acute hepatitis in mice

Innate Immunity, 2020
Melatonin is a well-documented hormone that plays central roles in the regulation of sleep–wake cycles. There is cumulative evidence to suggest that melatonin is also a pleiotropic regulator of inflammation, and luzindole has been widely used as a ...
Yisheng Luo, Yongqiang Yang, Yi Shen, Longjiang Li, Jiayi Huang, Li Tang, Li Zhang   +6 more
doaj   +1 more source

Prediction of regulatory targets of alternative isoforms of the epidermal growth factor receptor in a glioblastoma cell line. [PDF]

, 2019
BackgroundThe epidermal growth factor receptor (EGFR) is a major regulator of proliferation in tumor cells. Elevated expression levels of EGFR are associated with prognosis and clinical outcomes of patients in a variety of tumor types. There are at least
Ardell, David H, Eckert, Alexander W, Grosse, Ivo, Kappler, Matthias, Kotrba, Johanna, Vordermark, Dirk, Weinholdt, Claus, Wichmann, Henri   +7 more
core   +3 more sources

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Hepatoprotective activity of Dypsis lutescens against D-galactosamine-induced hepatotoxicity in rats and its phytoconstituents

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To isolate and identify the polyphenolic constituents of Dypsis lutescens, and evaluate the hepatoprotective activity of the ethanolic extract of Dypsis lutescens leaves.
Mai M El-Ghonemy, Walaa A El-Kashak, Tahia K Mohamed, Enayat A Omara, Jihan Hussein, Abdel-Razik H Farrag, Mahmoud I Nassar, Mohamed Y El-Kady   +7 more
doaj   +1 more source

The binding of glycosaminoglycans to peptides : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 1994
The overall aim this study was to examine the possibility of using immobilised polypeptide chains to fractionate/separate Glycosaminoglycans (GAG's) from mixtures. Initially individual samples of three GAG classes (chondroitin sulphate, dermatan sulphate
Taylor, Grant John
core  

Kytococcus aerolatus sp. nov., isolated from indoor air in a room colonized with moulds [PDF]

, 2009
A Gram-positive, coccoid bacterial isolate (02-St-019/1(T)), forming beige pigmented colonies was obtained from an indoor air sample. Based on 16S rRNA gene sequence similarity studies it was determined that this isolate 02-St-019/1(T) belonged to the ...
Kämpfer, Peter, Martin, Karin, Schumann, Peter, Schäfer, Jenny   +3 more
core   +1 more source

Dual‐Targeted Type‐I‐Photosensitizer‐Incorporated Covalent Organic Frameworks Overcome Hypoxia Barriers in Hepatocellular Carcinoma for Precision Therapy

Aggregate, Volume 7, Issue 3, March 2026.
A precise dual‐targeting covalent organic framework (COF) nanoplatform that avoids aggregation‐caused quenching (ACQ) to achieve synergistic high‐efficiency Type I photodynamic therapy and chemotherapy. ABSTRACT There is an urgent need to develop innovative therapeutic strategies for hepatocellular carcinoma (HCC) treatment with severe hypoxia ...
Xiang Wang, Hengrui Li, Yihan Ma, Le Wang, Miao Qin, Rui Lou, Jian Yin, Wenbo Ming, Yong Mao, Jing Hu   +9 more
wiley   +1 more source