Results 61 to 70 of about 26,061 (186)

LASP1, a Novel Protein in Spermatozoa and Acrosome Reaction

Molecular Reproduction and Development, Volume 93, Issue 7, July 2026.
LASP1 is expressed in spermatozoa, binds to F‐actin, and builds up the equatorial ring structure during acrosome reaction, which is important for hyaluronan receptor surface presentation. ABSTRACT LIM and SH3 protein 1 (LASP1) is a widely expressed scaffold protein associated with actin‐rich structures. In Lasp1‐knockout mice, reproductive defects such
Alicia Bender, Kilian Andress, Michael R. Boesl, Claudia Staib, Adriane Woehl‐Wenigerkind, Burkhard Kneitz, Hendrik Bartolomaeus, Alma Zernecke, Elke Butt   +8 more
wiley   +1 more source

The Protection of Midazolam Against Immune Mediated Liver Injury Induced by Lipopolysaccharide and Galactosamine in Mice

Frontiers in Pharmacology, 2019
Objectives: Liver macrophages agitated by Lipopolysaccharide (LPS) can enhance immuno-inflammatory responses in the liver which mediate liver injury and result in dysfunction.
Jian Li, Jian Li, Jian Li, Hong Tan, Hong Tan, Xiaona Zhou, Xiaona Zhou, Chunpan Zhang, Chunpan Zhang, Chunpan Zhang, Hua Jin, Hua Jin, Hua Jin, Yue Tian, Yue Tian, Yue Tian, Xinyan Zhao, Xinyan Zhao, Xinmin Li, Xinmin Li, Xinmin Li, Xuelian Sun, Xuelian Sun, Meili Duan, Meili Duan, Meili Duan, Dong Zhang, Dong Zhang, Dong Zhang, Dong Zhang   +29 more
doaj   +1 more source

V̇O2max$\dot V_{\rm{O_{2max}}}$‐based all‐out aerobic exercise attenuates hexosamine biosynthetic pathway activity: Metabolomic insights in mice model

Experimental Physiology, Volume 111, Issue 7, Page 3253-3266, 1 July 2026.
Abstract Aerobic exercise enhances physiological performance by activating metabolic systems, including glucose oxidation and fat metabolism. Cellular glucose predominantly flows through glycolysis (95–98%), whereas a smaller fraction (2–5%) enters the hexosamine biosynthetic pathway (HBP), generating UDP‐N‐acetylglucosamine.
Gyumin Kang, Eui‐Cheol Shin, Jae Kyeom Kim, Young Jun Kim   +3 more
wiley   +1 more source

Studies on Gluconeogenesis in Galactosamine Induced Hepatitis

Experimental Biology and Medicine, 1971
SummaryHepatitis was induced in animals treated with D-GalN-HCl (1.5 g/kg) in vitro. Incorporation of alanine-UL-14C, pyruvate-2-14C, and glutamic-3,4-14C acid into glucose by liver slices from GalN-treated animals was found decreased to 20-25% of the control values. The CO2 production from these substrates was impaired by 50%.
D, Monier, S R, Wagle
openaire   +2 more sources

The metabolism of d-galactosamine and N-acetyl-d-galactosamine in rat liver [PDF]

Biochemical Journal, 1968
d-[1−14C]Galactosamine appears to be utilized mainly by the pathway of galactose metabolism in rat liver, as evidenced by the products isolated from the acid-soluble fraction of perfused rat liver. These products were eluted in the following order from a Dowex 1 (formate form) column and were characterized as galactosamine 1-phosphate, sialic acid, UDP-
F, Maley, A L, Tarentino, J F, McGarrahan, R, Delgiacco   +3 more
openaire   +2 more sources

Hepatoprotective activity of Dypsis lutescens against D-galactosamine-induced hepatotoxicity in rats and its phytoconstituents

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To isolate and identify the polyphenolic constituents of Dypsis lutescens, and evaluate the hepatoprotective activity of the ethanolic extract of Dypsis lutescens leaves.
Mai M El-Ghonemy, Walaa A El-Kashak, Tahia K Mohamed, Enayat A Omara, Jihan Hussein, Abdel-Razik H Farrag, Mahmoud I Nassar, Mohamed Y El-Kady   +7 more
doaj   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, Volume 13, Issue 34, 19 June 2026.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Apolipoprotein C-III0 lacks carbohydrate residues: use of mass spectrometry to study apolipoprotein structure.

Journal of Lipid Research, 1989
Apolipoprotein C-III (apo C-III) is a 79 amino acid glycoprotein. The sugar moiety of apoC-III is attached to amino acid residue 74 and is thought to consist of 1 mole of galactose, 1 mole of N-acetyl-galactosamine, and either 0, 1, or 2 moles of sialic ...
Y Ito, J L Breslow, B T Chait
doaj   +1 more source

Intestinal lipoproteins in the rat with D-(+)-galactosamine hepatitis.

Journal of Lipid Research, 1983
D-(+)-galactosamine (GalN) induces severe reversible hepatocellular injury in the rat accompanied by lecithin: cholesterol acyltransferase (LCAT) deficiency, defective chylomicron (CM) catabolism, and accumulation of abnormal plasma lipoproteins (Lps ...
D D Black, P Tso, S Weidman, S M Sabesin
doaj   +1 more source