Tissue fractionation studies. 15. Intracellular distribution and properties of β-N-acetylglucos-aminidase and β-galactosidase in rat liver [PDF]
, 1960 OZ Sellinger +4 more
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Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging
Aging Cell, EarlyView.The molecular underpinnings of divergent cognitive trajectories in aging remain unresolved. Using high‐resolution behavioral testing to cognitively stratify aged male mice into ‘intact’ and ‘impaired’ subgroups, we show that reactive gliosis and cellular senescence are key determinants of disparities in cognitive function with age.
Matthew P. Baier +9 more
wiley +1 more source
Heterologous Production, Purification and Characterization of Two Cold-Active β-d-Galactosidases with Transglycosylation Activity from the Psychrotolerant Arctic Bacterium Arthrobacter sp. S3* Isolated from Spitsbergen Island Soil. [PDF]
Int J Mol SciWanarska M +3 more
europepmc +1 more source
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
Aging Cell, EarlyView.This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante +24 more
wiley +1 more source
Mechanistic Insights Into 5′‐tiRNA‐His‐GTG Mediated Activation of the JNK Pathway in Skin Photoaging
Aging Cell, EarlyView.5′‐tiRNA‐His‐GTG expression level is upregulated in the photoaging cell model. 5′‐tiRNA‐His‐GTG negatively regulates the expression of NUP98, thereby activating the JNK signaling pathway to regulate cell senescence. ABSTRACT UV exposure leads to skin damage, thus inducing skin aging.
Lihao Liu +10 more
wiley +1 more source
Towards an understanding of the enzymatic degradation of complex plant mannan structures. [PDF]
World J Microbiol Biotechnol, 2023 Mafa MS, Malgas S.
europepmc +1 more source
Genetic and Enzymatic Experiments Relating to the Tertiary Structure of β-Galactosidase [PDF]
, 1968 Joseph Langridge
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Aging Cell, EarlyView.This study demonstrates that aging induces oxidative stress and inflammation in the hematopoietic immune system, resulting in immune homeostasis dysfunction, including alterations in B cells and hematopoietic stem cells, senescent cells (SnCs) accumulation, and senescence‐associated secretory phenotypes (SASPs) production. Notably, the study highlights
Xiuxing Liu +11 more
wiley +1 more source
Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion. [PDF]
Nat MicrobiolBakshani CR +11 more
europepmc +1 more source