Biotechnological applications of functional metagenomics in the food and pharmaceutical industries [PDF]
, 2015 peer-reviewedMicroorganisms are found throughout nature, thriving in a vast range of environmental conditions. The majority of them are unculturable or difficult to culture by traditional methods.
Alvarez-Ordonez, Avelino +3 more
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Lactulose Biosynthesis with Enzymes of Lactose-Fermenting Micromycetes and Bacteria
Техника и технология пищевых производствLactulose is a well-studied prebiotic popular in medicine and the food industry. β-Galactosidases offer an alternative to traditional chemical methods of lactulose production. The article describes lactulose biosynthesis with crude enzyme preparations of
Svetlana A. Ryabtseva +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Senescence-associated beta-galactosidase is lysosomal beta-galactosidase
Aging Cell, 2006 Replicative senescence limits the proliferation of somatic cells passaged in culture and may reflect cellular aging in vivo. The most widely used biomarker for senescent and aging cells is senescence-associated beta-galactosidase (SA-beta-gal), which is defined as beta-galactosidase activity detectable at pH 6.0 in senescent cells, but the origin of SA-
LEE BY +8 more
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Structural Bioinformatics Analysis of GH42 Family β-Galactosidases
Shipin gongye ke-jiObjective: To elucidate the structural basis underlying the diverse extremophilic catalytic properties of β-galactosidases in the GH42 glycoside hydrolase family, enzymes with resolved crystal structures were systematically analyzed to reveal the ...
Mingfei GUO +4 more
doaj +1 more source
Present status on removal of raffinose family oligosaccharides - a Review
Czech Journal of Food Sciences, 2019 Raffinose family oligosaccharides (RFOs) are α-galactosyl derivatives of sucrose or glucose. They are found in a large variety of seeds from many different families such as beans, vegetables and whole grains.
Jian Zhang +5 more
doaj +1 more source
Biotechnology of Lactulose Production: Progress, Challenges, and Prospects
Техника и технология пищевых производств, 2023 Lactulose is a prebiotic that has found a wide application in medicine and food industry. Commercial lactulose is usually synthesized by isomerization in alkaline media at high temperatures.
Svetlana A. Ryabtseva +6 more
doaj +1 more source
Construction, Isolation and Implications of Repressor‐galactosidase ·ß‐galactosidase Hybrid Molecules [PDF]
European Journal of Biochemistry, 1977 Escherichia coli heterogenotes, which produce hybrid molecules between the chimaeric protein repressor‐galactosidase and the enzyme β‐galactosidase, were constructed. Repressor‐galactosidase. in which fully active lac repressor is covalently linked to active β‐galactosidase, is an aggregate with a core structure of four β‐galactosidase parts and two ...
J, Kania, B, Müller-Hill
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PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Biochemical characterization of digestive carbohydrases from Xanthogaleruca luteola and inhibition of its α-amylase by inhibitors extracted from the common bean [PDF]
, 2011 Xanthogaleruca luteola Müll. (Col.: Chrysomelidae) is a major urban insect pest on elm trees in Iran. Digestion in the alimentary canal of the elm leaf beetle is facilitated by some carbohydrases which are responsible for the digestion of ...
Ghadamyari Mohammad +3 more
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