Results 31 to 40 of about 633 (112)

Decrease in Myelin-Associated Lipids Precedes Neuronal Loss and Glial Activation in the CNS of the Sandhoff Mouse as Determined by Metabolomics [PDF]

, 2021
Sandhoff disease (SD) is a lysosomal disease caused by mutations in the gene coding for the β subunit of β-hexosaminidase, leading to deficiency in the enzymes β-hexosaminidase (HEX) A and B.
Boddie, Susannah, Cachon-Gonzalez, Begona, Cox, Timothy, Griffin, Julian L, Lecommandeur, Emanuelle, McNally, Ben, Nicholls, Andrew   +6 more
core   +1 more source

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface [PDF]

, 2017
Glycolipid antigens recognized by αβ T-cell receptors (TCRs) drive the activation of invariant natural killer T (iNKT) cells, a specialized subset of innate T lymphocytes.
Burdin, D. Branch Moody, Dale I. Godfrey, Daniel G. Pellicci, David C. Young, Gerald F. M. Watts, Gurdyal S. Besra, Jamie Rossjohn, Kanie, Michael B. Brenner, Natacha Veerapen, Patrick J. Brennan, Tan-Yun Cheng   +12 more
core   +2 more sources

C-Galactosylceramide diastereomers via Sharpless asymmetric epoxidation chemistry [PDF]

Tetrahedron, 2008
Abstract C-Glycoside analogs of α-galactosylceramide (KRN7000) were synthesized in 19 linear steps with Sharpless asymmetric epoxidation as a key reaction. Opening of a hydroxy epoxide with sodium azide provided an anti vicinal azido diol with inversion of configuration at the azide-bearing carbon while opening with Ti(O-i-Pr)2(N3)2 gave syn vicinal ...
Jun, Pu, Richard W, Franck
openaire   +2 more sources

Elevation of sulfatides in ovarian cancer: An integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry

Molecular Cancer, 2010
Background Sulfatides (ST) are a category of sulfated galactosylceramides (GalCer) that are elevated in many types of cancer including, possibly, ovarian cancer.
McDonald John F, Walker L, Matyunina Lilya V, Bowen Nathan J, Wang Elaine, Shaner Rebecca, Momin Amin, Chen Yanfeng, Liu Ying, Sullards M, Merrill Alfred H   +10 more
doaj   +1 more source

Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma. [PDF]

, 2019
As the most common cancer in men, prostate cancer is molecularly heterogeneous. Contributing to this heterogeneity are the poorly understood metabolic adaptations of the two main types of prostate cancer, i.e., adenocarcinoma and small cell ...
Alumkal, Joshi J, Fan, Sili, Fiehn, Oliver, Gao, Bei, Lue, Hui-Wen, Podolak, Jennifer, Serawat, Archana, Thomas, George V, Zhang, Ying   +8 more
core   +1 more source

CD1b Tetramers Bind \(\alpha \beta\) T Cell Receptors to Identify a Mycobacterial Glycolipid-Reactive T Cell Repertoire in Humans [PDF]

, 2013
Microbial lipids activate T cells by binding directly to CD1 and T cell receptors (TCRs) or by indirect effects on antigen-presenting cells involving induction of lipid autoantigens, CD1 transcription, or cytokine release. To distinguish among direct and
Altman, John D., Annand, John W., Brenner, Michael Barry, Cheng, Tan-Yun, de Jong, Annemieke, Kalathur, Ravi C., Kasmar, Anne G., Leon, Luis, Moody, D Branch, Schiefner, Andre, Seshadri, Chetan, Shires, John, Turner, Marie, Van Rhijn, Ildiko, Wilson, Ian A.   +14 more
core   +1 more source

Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor [PDF]

, 2021
Krabbe disease (KD) and metachromatic leukodystrophy (MLD) are caused by accumulation of the glycolipids galactosylceramide (GalCer) and sulfatide and their toxic metabolites psychosine and lysosulfatide, respectively.
Babcock, MC, Bhagwat, S, Chandra, S, Chandriani, S, Chao, Q, Crawford, BE, Feng, Y, Giaramita, A, Jiang, X, Lo, M, Mikulka, CR, Nelvagal, HR, Sands, MS, Shen, Y, Wang, B, Webster, K, Woloszynek, JC, Xu, Y, Yip, BK   +18 more
core   +1 more source

Modification of the host cell lipid metabolism induced by hypolipidemic drugs targeting the acetyl coenzyme A carboxylase impairs West Nile virus replication [PDF]

, 2017
West Nile virus (WNV) is a neurotropic flavivirus transmitted by the bite of mosquitoes that causes meningitis and encephalitis in humans, horses, and birds.
Casas, Josefina, Martín-Acebes, Miguel Ángel, Merino-Ramos, Teresa, Saiz, Juan Carlos, Sobrino Castelló, Francisco, Vázquez-Calvo, Ángela   +5 more
core   +1 more source

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor [PDF]

, 2020
Metachromatic leukodystrophy (MLD) is a rare genetic disease characterised by a dysfunction of the enzyme arylsulphatase A leading to the lysosomal accumulation of cerebroside sulphate (sulphatide) causing subsequent demyelination in patients. The enzyme
Baqi, Younis, Gieselmann, Volkmar, Guillaume, Joren, Li, Wenjin, Müller, Christa E., Van Calenbergh, Serge, Wachsmann, Isabell   +6 more
core   +2 more sources

NKT TCR Recognition of CD1d-α-C-Galactosylceramide [PDF]

The Journal of Immunology, 2011
Abstract NKT cells respond to a variety of CD1d-restricted glycolipid Ags that are structurally related to the prototypic Ag α-galactosylceramide (α-GalCer). A modified analog of α-GalCer with a carbon-based glycosidic linkage (α-C-GalCer) has generated great interest because of its apparent ability to promote prolonged, Th1-biased ...
Patel, Onisha, Cameron, Garth, Pellicci, Daniel G., Liu, Zheng, Byun, Hoe-Sup, Beddoe, Travis, McCluskey, James, Franck, Richard W., Castaño, A. Raúl, Harrak Serifi, Youssef, Llebaria, Amadeu, Bittman, Robert, Porcelli, Steven A., Godfrey, Dale I., Rossjohn, Jamie   +14 more
openaire   +3 more sources