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Galanthamin als Leitstruktur

, 2011
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Review of the acetylcholinesterase inhibitor galanthamine

Expert Opinion on Investigational Drugs, 2000
Galanthamine (or galantamine, Reminyl) is a tertiary alkaloid acetylcholinesterase inhibitor (AChEI) which has been approved in several countries for the symptomatic treatment of senile dementia of the Alzheimer's type. Derived from bulbs of the common snowdrop and several Amaryllidaceae plants, (-)-galanthamine (GAL) has long been used in anaesthetics
John J Sramek, N R Cutler
exaly   +3 more sources

The pharmacology of galanthamine and its analogues

Pharmacology & Therapeutics, 1995
Galanthamine is an alkaloid found in the bulbs of snowdrops and several Amaryllidaceae plants. At submicromolar concentrations, it inhibits acetylcholinesterase activity, but it is much less potent against butyrylcholinesterase activity. Galanthamine has been used in anaesthetics to reverse neuromuscular paralysis by tubocurarine-like muscle relaxants,
Alan L Harvey, A L Harvey
exaly   +5 more sources

Radioimmunoassay for the Quantitative Determination of Galanthamine

Planta Medica, 1990
A radioimmunoassay for the quantitation of pmol amounts of the therapeutically important Amaryllidaceae alkaloid, galanthamine, has been developed. The antiserum was raised against a conjugate of galanthamine-2-O-hemisuccinate-bovine serum albumin. The measuring range of the assay extends from 0.5 to 100 ng of galanthamine, and as little as 3.5 pmol ...
Takao Tanahashi, Alexander Poulev, Meinhart H Zenk   +2 more
exaly   +3 more sources