Results 71 to 80 of about 21,078 (260)

Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function [PDF]

open access: yes, 2017
Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding site, composed of a principal ...
Boffi, Juan Carlos   +11 more
core   +3 more sources

Exploring the Multifunctional Agents of Flavonoid‐Rich Beet Leaf Extracts: Insights From Experimental and Computational Studies

open access: yesFood Safety and Health, Volume 3, Issue 4, Page 723-739, October 2025.
ABSTRACT This study evaluated the multifunctional ability of Beta vulgaris leaves in dual therapy for Alzheimer's disease (AD) and type 2 diabetes (T2D). Flavonoid‐rich extracts of B. vulgaris leaves (FREBVL) were tested for their antidiabetic properties. The inhibition of α‐amylase and α‐glucosidase was assessed. Anti‐cholinesterase activities against
Gideon Ampoma Gyebi   +15 more
wiley   +1 more source

Increased Sensitivity to Agonist-Induced Seizures, Straub Tail, and Hippocampal Theta Rhythm in Knock-In Mice Carrying Hypersensitive α4 Nicotinic Receptors [PDF]

open access: yes, 2003
We studied a strain of exon replacement mice (“L9′S knock-in”) whose α4 nicotinic receptor subunits have a leucine to serine mutation in the M2 region, 9′ position (Labarca et al., 2001); this mutation renders α4-containing receptors hypersensitive to ...
Collins, Allan C.   +9 more
core  

Deciphering of nutritional profile, therapeutic potential, and networking of bioactive compounds of Moringa oleifera: A comprehensive review

open access: yesFood Biomacromolecules, Volume 2, Issue 3, Page 271-287, September 2025.
The graphical abstract signifies the nutritional profile of various parts of the Moringa oleifera plant, including dried leaves, fresh leaves, leaf powder, seeds, and pods; along with it’s bioactive substance and protein profiling of aqueous concentrates derived from the fruit, seed, and leaf.
Rajesh Kumar   +5 more
wiley   +1 more source

Daffodils as Potential Crops of Biologically-active Compounds: Assessment of 40 Ornamental Taxa for their Alkaloid Profile and Cholinesterases Inhibition Activity

open access: yesNatural Product Communications, 2018
Many varieties of Narcissus (Amaryllidaceae) are planted on a large scale for ornamental purposes and at the same time they represent a rich reservoir of potential small chemical molecules that display several medicinal properties.
Kateřina Breiterová   +6 more
doaj   +1 more source

Comprehensive Metabolomic Profiling and Biological Activity Analysis of Eschscholzia californica Extracts Using LC‐ESI‐QTOF‐MS

open access: yesFood Science &Nutrition, Volume 13, Issue 9, September 2025.
The results indicate the potential pharmacological applications of Eschscholzia californica's aerial parts as a source for the development of novel phytopharmaceuticals targeting conditions such as insomnia, schizophrenia, and depression. ABSTRACT The current investigation was designed to explore the chemical composition, antioxidant capacity, enzyme ...
Alina Kalyniukova   +9 more
wiley   +1 more source

Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)

open access: yesChemistry &Biodiversity, Volume 22, Issue 8, August 2025.
This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni   +5 more
wiley   +1 more source

Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]

open access: yes, 2016
Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
core   +1 more source

Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species

open access: yesChemistryOpen, Volume 14, Issue 8, August 2025.
The tested Phlomis species are a rich source of bioactive molecules with potential therapeutic applications, and selecting appropriate extraction solvents is crucial for achieving the targeted biological activity. Phlomis species (family Lamiaceae) are highly valued as food and herbal medicine.
Sakina Yagi   +8 more
wiley   +1 more source

Stability and enzymatic studies with omeprazole: hydroxypropyl-β-cyclodextrin [PDF]

open access: yes, 2010
The original publication is available at www.springerlink.com. A publicação original está disponível em www.springerlink.comOmeprazole (OME) exhibits low stability to light, heat and humidity.
A Hedges   +29 more
core   +1 more source

Home - About - Disclaimer - Privacy