Results 51 to 60 of about 21,078 (260)

Identification of Alkaloids from Hippeastrum aulicum (Ker Gawl.) Herb.(Amaryllidaceae) Using CGC-MS and Ambient Ionization Mass Spectrometry (PS-MS and LS-MS) [PDF]

, 2017
Amaryllidaceae alkaloids are well-known isoquinolines which have demonstrated a wide range of biological activities such as antiviral, anticancer, acetylcholinesterase inhibition, antimalarial, among others.
Andrade, Jean Paulo de, Bastida Armengol, Jaume, Bessa, Carliani D.P.B., Borges, Warley S., Domingos, Eloilson, Oliveira, Renata S. de, Romão, Wanderson, Santos, Heloa   +7 more
core   +1 more source

Chemical Constituents and Biological Potentials of Teucrium scordium subsp. scordioides Extracts: In Vitro Experimental and In Silico Perspectives

ChemistryOpen, Volume 15, Issue 5, May 2026.
T. scordium subsp. scordioides may represent a natural source of antioxidants and enzyme inhibitors for use in different health‐promoting formulations. This study was undertaken to examine, for the first time, the antioxidant and enzyme inhibitory properties of several extracts obtained from the aerial parts of Teucrium scordium subsp.
Bengusu Hacer Akgul, Sakina Yagi, Mehmet Veysi Cetiz, Enver Saka, Gokhan Zengin, Eulogio J. Llorent‐Martínez, Marina Gómez‐Torres, Ismail Yapıcı, Ilhami Gulcin, Evren Yıldıztugay   +9 more
wiley   +1 more source

Elucidating the enzyme network driving Amaryllidaceae alkaloids biosynthesis in Leucojum aestivum. [PDF]

Plant Biotechnol J
Schematic representation of Amaryllidaceae alkaloid biosynthesis in Leucojum aestivum. Norbelladine synthase (LaNBS) and noroxomaritidine/norcraugsodine reductase (LaNRII) catalyze the condensation of tyramine and 3,4‐dihydroxybenzaldehyde to form norbelladine, which is subsequently O‐methylated by norbelladine‐4′‐O‐methyltransferase (LaN4′OMT ...
Lamichhane B, Gélinas SE, Merindol N, Koirala M, Dos Santos KCG, Germain H, Desgagné-Penix I.   +6 more
europepmc   +2 more sources

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer’s Disease [PDF]

, 2013
This review describes the preclinical mechanisms that may underlie the increased therapeutic benefit of combination therapy—with the N-methyl-d-aspartate receptor antagonist, memantine, and an acetylcholinesterase inhibitor (AChEI)—for the treatment of ...
Andrzej Dekundy, Chris G. Parsons, Irena Pulte, Wojciech Danysz   +3 more
core   +1 more source

Organ‐Specific Phytochemical Composition and Bioactivity Profiling of Chaerophyllum aksekiense: A Multiassay Antioxidant, Enzyme Inhibition, and Correlation‐Based Evaluation

ChemistryOpen, Volume 15, Issue 5, May 2026.
This study reveals the organ‐specific phytochemical specialization of the endemic Chaerophyllum aksekiense for the first time. Although leaves exhibit the highest phenolic content and antioxidant capacity, flowers stand out with flavonoid accumulation, and roots demonstrate potent enzyme inhibition.
Bedrettin Selvi, Elif Aktürk Bozdemir
wiley   +1 more source

Design, synthesis and biological evaluation of 1,3-dihydroxyxanthone derivatives: Effective agents against acetylcholinesterase [PDF]

, 2017
The present work concerns the rational design and development of new inhibitors of acetylcholinesterase (AChE) based on the privileged xanthone scaffold.
Accordino, Sebastian Roberto, Appignanesi, Gustavo Adrian, Biscussi, Brunella, Gerbino, Darío César, Menéndez, Cintia Anabella, Murray, Ana Paula   +5 more
core   +1 more source

Phytochemical Diversity, Nutritional Values, and Biological Properties of Halopithys incurva (Hudson) Batters, 1902

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Halopithys incurva is a red macroalga distributed across the Mediterranean Sea and North‐East Atlantic, with occasional reports from the Indian Ocean. It exhibits a rich chemical diversity, including isoflavones, bromophenols, MAAs, pigments, phycobiliproteins, primary metabolites, and neuroactive compounds.
Youssra Aalilou, Abdelhakim Bouyahya, Kaoutar Benrahou, Mustapha Hassoun, Hanaa Moussa, Issam Ameziane El Hassani, Waleed Al Abdulmonem, Learn‐Han Lee, Gokhan Zengin, My El Abbes Faouzi   +9 more
wiley   +1 more source

Dual Targeting of DNA and EGFR by ZYH005 Induces DNA Damage and Mitotic Catastrophe in Glioblastoma

MedComm, Volume 7, Issue 4, April 2026.
ZYH005 exerts potent anti‐glioblastoma activity through a dual mechanism: intercalation‐mediated DNA damage and targeted inhibition of EGFR, leading to cell cycle arrest and mitotic catastrophe. ABSTRACT Glioblastoma multiforme (GBM) is an aggressive, therapy‐resistant brain tumor with limited treatment options.
Jianzheng Huang, Zijun Zhang, Yang Xiao, Ziming Zhao, Zengwei Luo, Junjun Liu, Suitian Lai, Chao Song, Shouchang Feng, Suojun Zhang, Xingjiang Yu, Qingyi Tong, Yonghui Zhang   +12 more
wiley   +1 more source

Bioactive Phenolic Compounds from Thapsia garganica L. Different Parts: HPLC‐DAD Profiling,Cholinesterase Inhibition, and Antioxidant Potential

ChemistrySelect, Volume 11, Issue 1, 8 January 2026.
ABSTRACT This study investigates the biological properties of methanolic and petroleum ether (PE) extracts from the roots and flowers of Thapsia garganica L., providing new insights into its potential medicinal uses. Although T. garganica has a long history in traditional medicine, the anticholinesterase and tyrosinase‐inhibiting activities of this ...
Rania Arabi, Meriem Chafaa, Dilaycan Çam, Cansel Çakir, Zohra Arabi, Leila Soudani, Mehmet Öztürk, Tarek H. Taha, Sulaiman A. Alsalamah, Takfarinas Idres, Stefania Garzoli, Hamdi Bendif   +11 more
wiley   +1 more source

Pharmacognosy: Science of natural products in drug discovery [PDF]

BioImpacts, 2014
Pharmacognosy deals with the natural drugs obtained fromorganisms such as most plants, microbes, and animals. Up todate, many important drugs including morphine, atropine,galanthamine, etc.
Ilkay Erdogan Orhan
doaj   +1 more source