Results 51 to 60 of about 18,076 (169)

Dual Targeting of DNA and EGFR by ZYH005 Induces DNA Damage and Mitotic Catastrophe in Glioblastoma

MedComm, Volume 7, Issue 4, April 2026.
ZYH005 exerts potent anti‐glioblastoma activity through a dual mechanism: intercalation‐mediated DNA damage and targeted inhibition of EGFR, leading to cell cycle arrest and mitotic catastrophe. ABSTRACT Glioblastoma multiforme (GBM) is an aggressive, therapy‐resistant brain tumor with limited treatment options.
Jianzheng Huang, Zijun Zhang, Yang Xiao, Ziming Zhao, Zengwei Luo, Junjun Liu, Suitian Lai, Chao Song, Shouchang Feng, Suojun Zhang, Xingjiang Yu, Qingyi Tong, Yonghui Zhang   +12 more
wiley   +1 more source

Analysis of Bioactive Amaryllidaceae Alkaloid Profiles in Species by GC-MS

Natural Product Communications, 2014
The genus Lycoris , a group of Amaryllidaceae plants distributed in temperate regions of Eastern Asia, is already known for containing representative alkaloids typical of this botanical family with a wide range of biological activities (for example ...
Ying Guo, Natalia B. Pigni, Yuhong Zheng, Jean Paulo de Andrade, Laura Torras-Claveria, Warley de Souza Borges, Francesc Viladomat, Carles Codina, Jaume Bastida   +8 more
doaj   +1 more source

Crinum jagus: antiproliferative studies of extracts on HepG2 cell line and in silico assessment of phytoconstituents as potential inhibitors of p53–mortalin interaction

Future Journal of Pharmaceutical Sciences, 2023
Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide and has a poor prognosis in black Africans. Traditional herbal practitioners in southwestern Nigeria use Crinum jagus (J. Thompson) Dandy for cancer treatment.
Taye Temitope Alawode, Labunmi Lajide, Mary Olaleye, Bodunde Owolabi   +3 more
doaj   +1 more source

Comprehensive Exploration of Three Pistachio Varieties: Antidiabetic, Anticholinergic, Antioxidant Properties, Phytochemical Profile by LC–MS/MS, and Molecular Docking

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Phytochemical profiles, biological activities, and molecular docking studies of pistachio varieties. ABSTRACT Pistachios (Pistacia vera L.) are a significant food that is added to many foods and also consumed as a snack. The kernel part is consumed very much.
Ebubekir İzol, Büşra Beltekin, Münire Turhan, Şirvan Karakoç, Adem Necip, Mustafa Abdullah Yılmaz, Gökhan Zengin, Oğuz Çakır   +7 more
wiley   +1 more source

Bioactive Phenolic Compounds from Thapsia garganica L. Different Parts: HPLC‐DAD Profiling,Cholinesterase Inhibition, and Antioxidant Potential

ChemistrySelect, Volume 11, Issue 1, 8 January 2026.
ABSTRACT This study investigates the biological properties of methanolic and petroleum ether (PE) extracts from the roots and flowers of Thapsia garganica L., providing new insights into its potential medicinal uses. Although T. garganica has a long history in traditional medicine, the anticholinesterase and tyrosinase‐inhibiting activities of this ...
Rania Arabi, Meriem Chafaa, Dilaycan Çam, Cansel Çakir, Zohra Arabi, Leila Soudani, Mehmet Öztürk, Tarek H. Taha, Sulaiman A. Alsalamah, Takfarinas Idres, Stefania Garzoli, Hamdi Bendif   +11 more
wiley   +1 more source

Daffodils as Potential Crops of Biologically-active Compounds: Assessment of 40 Ornamental Taxa for their Alkaloid Profile and Cholinesterases Inhibition Activity

Natural Product Communications, 2018
Many varieties of Narcissus (Amaryllidaceae) are planted on a large scale for ornamental purposes and at the same time they represent a rich reservoir of potential small chemical molecules that display several medicinal properties.
Kateřina Breiterová, Miroslav Ločárek, Eliška Kohelová, Markéta Talácková, Daniela Hulcová, Lubomír Opletal, Lucie Cahlíková   +6 more
doaj   +1 more source

Biofunctional Properties of RuBisCO Extract From Spinacia oleracea L.

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Spinach (Spinacia oleracea L.) is a green herbaceous annual leafy vegetable widely cultivated. It is considered a functional food for its nutritional composition, phytochemicals and bioactive compounds that contribute to reduce oxidative stress, inducing the secretion of satiety hormones helping to promote protection mechanisms against hypoglycaemia ...
Lorenza Marinaccio, Giulia Gentile, Federica Flamminii, Gokhan Zengin, Lorenzo Cerretani, Silvia Minetti, Angelo Cichelli, Adriano Mollica, Azzurra Stefanucci, Pei Li   +9 more
wiley   +1 more source

Quantititative Determination of Lycorine and Galanthamine in and by HPLC-DAD

Natural Product Communications, 2014
Lycorine and galanthamine have various biological activities. A reliable HPLC method coupled with DAD detection was developed and validated for the determination of galanthamine and lycorine in Galanthus trojanus and G. cilicicus. A simple method for the
Gulen Irem Kaya, Derya Cicek Polat, Buket Sarikaya, Mustafa Ali Onur, Nehir Unver Somer   +4 more
doaj   +1 more source

Hydrolyzed Proteins From Brewer's Spent Yeast as an Ingredient With Bioaccessible Antihypertensive and Neuroprotective Properties

Sustainable Food Proteins, Volume 3, Issue 4, December 2025.
The aims of this work were to obtain bioactive peptides from brewer's spent yeast (BSY) proteins and to evaluate its antihypertensive and neuroprotective properties before and after the simulated gastrointestinal digestion and in vitro colonic fermentation process. All samples showed antihypertensive and neuroprotective properties.
Marilin E. Aquino, Silvina R. Drago, María I. Gomez, Raúl E. Cian   +3 more
wiley   +1 more source

Recent Advances in Ene Reactions with Carbon Enophiles

Advanced Synthesis &Catalysis, Volume 367, Issue 22, November 28, 2025.
Recent advances in the classical intra‐ and intermolecular ene nexus with carbon enophiles (alkenes, alkynes, arynes, and allenes) show a considerable increase in structural complexity and an enormous potential for functional applications in polymer science.
Thomas J. J. Müller
wiley   +1 more source