Results 31 to 40 of about 18,076 (169)

Phytochemical Screening of Rosmarinus officinalis L. as a Potential Anticholinesterase and Antioxidant–Medicinal Plant for Cognitive Decline Disorders

Plants, 2022
The inhibition of acetylcholinesterase (AChE) by cholinergic agents has been promoted as a potent strategy for treating and managing cognitive decline disorders.
Majid Rasool Kamli, Abeer Abdullah M. Sharaf, Jamal S. M. Sabir, Irfan A. Rather   +3 more
doaj   +1 more source

Transcriptome Analysis of Different Tissues Reveals Key Genes Associated With Galanthamine Biosynthesis in Lycoris longituba

Frontiers in Plant Science, 2020
Lycoris longituba is a traditional medicinal plant containing the bioactive compound galanthamine (Gal), a type of Amaryllidaceae alkaloid and can be used to treat Alzheimer’s disease. However, research on its genome or transcriptome and associated genes
Qingzhu Li, Junxu Xu, Liuyan Yang, Xiaohui Zhou, Youming Cai, Yongchun Zhang   +5 more
doaj   +1 more source

Alkaloid Synthesis and Accumulation in Cultures

Natural Product Communications, 2009
The alkaloids of intact plants, calli and shoot-clump cultures of L. aestivum were analyzed by GC-MS. Twenty-four alkaloids were detected. Calli appeared to produce sparse alkaloid profiles in stark contrast to shoot-clumps that had similar profiles to ...
Strahil Berkov, Atanas Pavlov, Vasil Georgiev, Jaume Bastida, Monique Burrus, Mladenka Ilieva, Carles Codina   +6 more
doaj   +1 more source

Alkaloids from Hippeastrum papilio

Molecules, 2011
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer’s disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus ...
Jaume Bastida, Jean Paulo de Andrade, José Angelo S. Zuanazzi, Carles Codina, Francesc Viladomat, Strahil Berkov   +5 more
doaj   +1 more source

Unlocking the Antioxidant, Enzyme Inhibitory and Acaricidal Potential of <i>Azadirachta indica</i> Phytoconstituents Using In Vitro and In Silico Approaches. [PDF]

Food Sci Nutr
The study evaluated the acaricidal potential of bioactive components of Azadirachta indica against scabies mortality using both in vitro and in silico methodologies. Sarcoptes scabiei were stimulated with Azadirachta indica at four concentrations (25–100 mg/mL) at different intervals.
Fatima T, Abbas M, Zafar K, Zafar MG, Haider W, Zafar MH, Riaz M, Iqbal M, Mtewa AG.   +8 more
europepmc   +2 more sources

Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176. [PDF]

PLoS ONE, 2013
The limited symptom relief and side effects of current Alzheimer's disease (AD) medications warrant urgent discovery and study of new anti-AD agents. The "cholinergic hypothesis" of AD prompts us to search for plant-derived acetylcholineesterase (AChE ...
Lijuan Xin, Ritupriya Yamujala, Yuehu Wang, Huan Wang, Wen-Hsuan Wu, Michael A Lawton, Chunlin Long, Rong Di   +7 more
doaj   +1 more source

Bio-Guided Fractionation of Stem Bark Extracts from Phyllanthus muellarianus: Identification of Phytocomponents with Anti-Cholinesterase Activity

Molecules, 2021
A combination of flash chromatography, solid phase extraction, high-performance liquid chromatography, and in vitro bioassays was used to isolate phytocomponents endowed with anticholinesterase activity in extract from Phyllanthus muellarianus ...
Marina Naldi, Gloria Brusotti, Gabriella Massolini, Vincenza Andrisano, Caterina Temporini, Manuela Bartolini   +5 more
doaj   +1 more source

Dynamics of Growth and Galanthamine Biosynthesis in Hippeastrum papilio (Ravena) Van Sheepen Hydroponic Culture

Agronomy
Hippeastrum papilio (Ravena) van Sheepen is a bulbous evergreen species and considered a potential new source of galanthamine. This natural compound approved by the FDA is used for the cognitive treatment of Alzheimer’s disease.
Gabriela Haist, Borjana Sidjimova, Rumen Denev, Jaume Bastida, Strahil Berkov   +4 more
doaj   +1 more source

Wild Argentinian Amaryllidaceae, a New Renewable Source of the Acetylcholinesterase Inhibitor Galanthamine and Other Alkaloids

Molecules, 2012
The Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer&#8217;s disease involves the inhibition of the enzyme acetylcholinesterase (AChE).
Gabriela E. Feresin, Jaume Bastida, Alejandro Tapia, German Roitman, Cristina Theoduloz, Strahil Berkov, Natalia B. Pigni, Javier E. Ortiz   +7 more
doaj   +1 more source

ALKALOIDS FROM HAEMANTHUS MULTIFLORUS MARTYN [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1987
Phytochemical study of the alkaloidal content of Haemanthus multiflorus Martyn grown in Ethiopia, Resulted in the isolation and characterization of lycorine, in addition to galanthamine and sanguinine, are to be reported for the first time from this ...
E. Dagne, W. Steglich, O. Abdalla, H. Sayed, A. Ali   +4 more
doaj   +1 more source