Alkaloid Synthesis and Accumulation in Cultures
Natural Product Communications, 2009 The alkaloids of intact plants, calli and shoot-clump cultures of L. aestivum were analyzed by GC-MS. Twenty-four alkaloids were detected. Calli appeared to produce sparse alkaloid profiles in stark contrast to shoot-clumps that had similar profiles to ...
Strahil Berkov +6 more
doaj +1 more source
Natural AChE inhibitors from plants and their contribution to Alzheimer´s disease therapy [PDF]
, 2013 As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity.
Alza, Natalia Paola +4 more
core +2 more sources
Molecules, 2021 A combination of flash chromatography, solid phase extraction, high-performance liquid chromatography, and in vitro bioassays was used to isolate phytocomponents endowed with anticholinesterase activity in extract from Phyllanthus muellarianus ...
Marina Naldi +5 more
doaj +1 more source
Composição química, atividades inibidora da acetilcolinesterase e antifúngica de Pera glabrata (Schott) Baill. (Euphorbiaceae) [PDF]
, 2009 Pera glabrata (Schott) Baill. was selected for this study after showing a preliminary positive result in a screening of Atlantic Forest plant species in the search for acetylcholinesterase inhibitors and antifungal compounds. The bioassays were conducted
BARBO, Fausto Erritto +6 more
core +2 more sources
Alkaloids from Hippeastrum papilio
Molecules, 2011 Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer’s disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus ...
Jaume Bastida +5 more
doaj +1 more source
Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176. [PDF]
PLoS ONE, 2013 The limited symptom relief and side effects of current Alzheimer's disease (AD) medications warrant urgent discovery and study of new anti-AD agents. The "cholinergic hypothesis" of AD prompts us to search for plant-derived acetylcholineesterase (AChE ...
Lijuan Xin +7 more
doaj +1 more source
Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone [PDF]
, 2013 BACKGROUND: Biotransformation is an effective technique for the synthesis of libraries of bioactive compounds. Current study on microbial transformation of dihydrotestosterone (DHT) (1) was carried out to produce various functionalized metabolites ...
Kourosh Dalvandi +4 more
core +2 more sources
Peptides binding cocaine: A strategy to design biomimetic receptors [PDF]
, 2013 A computational methodology for designing and rationalizing the selection of small peptides as biomimetic receptors for cocaine is proposed. The method started by searching and filtering proteins X-ray and NMR data of biological receptor-cocaine ...
Compagnone, Dario +6 more
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Production and antioxidant capacity of tissue cultures from four Amaryllidaceae species [PDF]
, 2017 The aim of this study was (i) to produce tissue cultures capable of efficient plant regeneration from European naturally occurring protected and/or pharmacologically important Amaryllidaceae species and (ii) to test them for antioxidant activities in ...
Ajtay, Kitti +7 more
core +3 more sources
AgronomyHippeastrum papilio (Ravena) van Sheepen is a bulbous evergreen species and considered a potential new source of galanthamine. This natural compound approved by the FDA is used for the cognitive treatment of Alzheimer’s disease.
Gabriela Haist +4 more
doaj +1 more source