Wild Argentinian Amaryllidaceae, a New Renewable Source of the Acetylcholinesterase Inhibitor Galanthamine and Other Alkaloids [PDF]
The Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer’s disease involves the inhibition of the enzyme acetylcholinesterase (AChE).
Gabriela E. Feresin +7 more
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Stereocontrolled Synthesis of (−)-Galanthamine [PDF]
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Satcharoen, V. +4 more
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4a,5,9,10,11,12-Hexahydro-6H-benzo[a]cyclohepta[hi]benzofuran - Synthesis of Unnatural Galanthamine Analogs [PDF]
The synthesis of an unnatural galanthamine analog is ...
Ulrich Jordis, Matthias Treu
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Quantititative Determination of Lycorine and Galanthamine in and by HPLC-DAD [PDF]
Lycorine and galanthamine have various biological activities. A reliable HPLC method coupled with DAD detection was developed and validated for the determination of galanthamine and lycorine in Galanthus trojanus and G. cilicicus. A simple method for the
Gulen Irem Kaya +4 more
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Integrating Narcissus-derived galanthamine production into traditional upland farming systems
Alzheimer’s disease (AD) is a disorder associated with progressive degeneration of memory and cognitive function. Galantamine is a licenced treatment for AD but supplies of the plant alkaloid that it is produced from, galanthamine, are limited.
M. D. Fraser +4 more
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Chemical Survey of Three Species of the Genus Rauhia Traub (Amaryllidaceae)
Plant biodiversity is an important source of compounds with medicinal properties. The alkaloid galanthamine, first isolated from Galanthus woronowii (Amaryllidaceae), is approved by the FDA for the palliative treatment of mild to moderate Alzheimer’s ...
Luciana R. Tallini +7 more
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As global ageing deepens and galanthamine is the preferred clinical drug for the treatment of mild to moderate Alzheimer’s disease, it will be valuable to examine the behaviour and mechanism of galanthamine’s thermal decomposition for its quality control,
Chong Qin +3 more
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Light-emitting diodes (LEDs) have emerged as efficient light sources for promoting in vitro plant growth and primary and secondary metabolite biosynthesis. This study investigated the effects of blue, red, and white-red LED lights on plant biomass growth,
Emilia Morańska +7 more
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Fluorometric determination of galanthamine
Yoji ICHIMURA, Kazumitsu NISHIMOTO
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Cloning and characterization of a norbelladine 4'-O-methyltransferase involved in the biosynthesis of the Alzheimer's drug galanthamine in Narcissus sp. aff. pseudonarcissus. [PDF]
Galanthamine is an Amaryllidaceae alkaloid used to treat the symptoms of Alzheimer's disease. This compound is primarily isolated from daffodil (Narcissus spp.), snowdrop (Galanthus spp.), and summer snowflake (Leucojum aestivum).
Matthew B Kilgore +6 more
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