Results 111 to 120 of about 36,130 (196)

Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20 [PDF]

, 2018
Bunyaviruses pose a significant threat to human health, prosperity and food security. In response to viral infections, interferons (IFNs) upregulate the expression of hundreds of interferon stimulated genes (ISGs) whose cumulative action can potently ...
Bieniasz, Paul D., Brennan, Benjamin, Elliott, Richard M., Feng, Junjie, Koudriakova, Elina, Kreher, Felix, Rezelj, Veronica V., Rice, Charles M., Rihn, Suzannah J., Shaw, Andrew E., Shi, Xiaohong, Slack, Gillian S., Tilston-Lunel, Natasha L., Turnbull, Matthew L., Wickenhagen, Arthur, Wilson, Sam J.   +15 more
core   +1 more source

Fibrosis‐Driven Surgical Risk After Thyroid Nodule Ablation: Quantitative Clinicopathological Determinants of Complications in Post‐Ablative Thyroidectomy—A Retrospective Cohort Study

World Journal of Surgery, EarlyView.
Thermal ablation is increasingly used for selected benign and low‐risk thyroid nodules, yet some patients still require thyroidectomy for regrowth, persistent symptoms, or new oncologic concern. The surgical and pathological impact of ablation‐induced remodeling remains incompletely defined.
Daqi Zhang, Alvino Boero, Giacomo Gazzano, Andrea Satta, Laura Fugazzola, Carla Colombo, Francesco Brucchi, Gianlorenzo Dionigi   +7 more
wiley   +1 more source

Liver eosinophilic infiltrate is a significant finding in patients with chronic hepatitis C. [PDF]

, 2008
Eosinophilic infiltrate of liver tissue is described in primary cholestatic diseases, hepatic allograft rejection and drug-induced liver injury, but its significance and its implications in chronic hepatitis C are unknown.
ALESSI, N, CABIBI, Daniela, CAMMA', Calogero, CRAXI, Antonio, DI MARCO, Vito, DONATELLI, Maria, PETTA, Salvatore, TARANTINO, Giuseppe   +7 more
core   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1 [PDF]

, 2016
Galectin-1 (Gal-1), a glycan-binding protein with broad antiinflammatory activities, functions as a proresolving mediator in autoimmune and chronic inflammatory disorders. However, its role in allergic airway inflammation has not yet been elucidated.
Abramoff, Ada G. Blidner, Amrita Rao, Boehme, Gabriel A. Rabinovich, Ge, Ha, He, Idil Bastan, Matsuura, P. Sriramarao, Rabinovich, Savita P. Rao, Sung Gil Ha, Xiao Na Ge, Yana G. Greenberg   +15 more
core   +1 more source

Single‐Cell Omics Analysis of Human Basophils Reveals Two Transcriptionally Distinct Populations

Allergy, EarlyView.
Integrated single‐cell transcriptomics and large‐scale immunophenotyping reveal the molecular landscape of human basophils. Circulating basophils comprise two transcriptionally distinct populations. A user‐friendly web resource enables interactive exploration of the generated data.
Sofia Papavasileiou, Jiezhen Mo, Daryl Boey, Chenyan Wu, Magnus Tronstad, Lucille Margerie, Remi‐André Olsen, Jörg A. Bachmann, Jing Hui Low, Jocelyn Ong, Lars Heede Blom, Anand Kumar Andiappan, Gunnar Nilsson, Joakim S. Dahlin   +13 more
wiley   +1 more source

Glycobiology of immune responses [PDF]

, 2012
Unlike their protein roommates and their nucleic acid cousins, carbohydrates remain an enigmatic arm of biology. The central reason for the difficulty in fully understanding how carbohydrate structure and biological function are tied is the non-template ...
Aarnoudse, Amith, Amith, Andersson, Angata, Anthony, Avril, Banh, Birkholz, Blasius, Blixt, Boscher, Bozzacco, Bozzacco, Brewer, Brockhausen, Brown, Burgdorf, Buzás, Caminischi, Carlin, Cedeno-Laurent, Comelli, Cooper, Crocker, Dai, Dam, Dardalhon, de Witte, Demetriou, Demotte, Denda-Nagai, Di Lella, Drickamer, Dube, Engering, Figdor, Forsman, Garcia-Vallejo, Garner, Geijtenbeek, Geijtenbeek, Geijtenbeek, Gow, Green, Grigorian, Gringhuis, Gringhuis, Harrison, Hiki, Idoyaga, Ilarregui, Jellusova, Jiang, Ju, Juszczynski, Kaneko, Kawasaki, Kel, Klechevsky, Krinos, Kuo, Lambert, Levine, Li, Liu, Liu, Lowe, Matsushita, Mitoma, Nicoll, Nothaft, Oberg, Ohta, Ohtsubo, Osorio, O’Reilly, O’Reilly, Padler-Karavani, Park, Pashov, Paul, Rabinovich, Rubinstein, Ryan, Saeland, Saeland, Salatino, Sancho, Sato, Singh, Singh, Singh, Soldati, Sperandio, Stanley, Stanley, Streng-Ouwehand, Sánchez-Navarro, Takahashi, Tang, Theodore, Toscano, Tsuboi, Unger, Van Die, Van Geet, van Gisbergen, van Gisbergen, van Kooyk, van Kooyk, van Vliet, van Vliet, Wang, Zelensky, Zhou, Zhu   +116 more
core   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source