Results 41 to 50 of about 36,130 (196)

Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease [PDF]

, 2013
Background: Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (T(H)1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic
A Sanchez-Fueyo, Akihiro Katayama, AS Levey, Atsuko Nakatsuka, C Zhu, Chigusa Higuchi, F Wang, Hirofumi Makino, J Klibi, J Wada, J Wada, JA Mengshol, Jun Eguchi, Jun Wada, K Igawa, Kazutoshi Murakami, Kentaro Inoue, M Baba, M Kanzaki, Mayu Watanabe, Motoko Kanzaki, Nobuyuki Miyatake, O Tureci, P Jayaraman, S de Kivit, S Matsuo, S Sehrawat, Sanae Teshigawara, SH Barondes, T Imaizumi, Takahiro Terami, WJ Chirico, Y Tsuchiyama, Yuko Kurose   +33 more
core   +2 more sources

Clinical Significance of Serum Galectin-9 and Soluble CD155 Levels in Patients with Systemic Sclerosis

Journal of Immunology Research, 2018
Signaling through coinhibitory receptors downregulates the immune response to prevent excessive immune activation and maintain optimal immunity and tolerance.
Mami Chihara, Miki Kurita, Yuki Yoshihara, Akihiko Asahina, Koichi Yanaba   +4 more
doaj   +1 more source

Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937 [PDF]

, 2016
In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells).
Albarracín, Leonardo Miguel, Aso, Hisashi, Ikeda-Ohtsubo, Wakako, Kanmani, Paulraj, Kano, Hiroshi, Kitazawa, Haruki, Kobayashi, Hisakazu, Kober, Humayun A.K.M., Makino, Seiya, Nochi, Tomonori, Ohkawara, Sou, Saito, Tadao, Sato, Nana, Suda, Yoshihito, Villena, Julio Cesar   +14 more
core   +1 more source

Immunomodulator Galectin-9 is Increased in Blood and Skin of Patients with Bullous Pemphigoid

Acta Dermato-Venereologica, 2021
Massive recruitment of eosinophils into the dermis is a hallmark of bullous pemphigoid pathogenesis. Identifying the chemoattractant(s) guiding eosinophils into the skin in bullous pemphigoid is a prerequisite to thera­peutic targeting of eosinophil ...
Jasper Pruessmann, Wiebke Pruessmann, Maike M. Holtsche, Beke Linnemann, Christoph M. Hammers, Nina van Beek, Detlef Zillikens, Enno Schmidt, Christian D. Sadik   +8 more
doaj   +1 more source

Graves' disease is associated with a defective expression of the immune regulatory molecule galectin-9 in antigen-presenting dendritic cells [PDF]

, 2015
Introduction Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function of galectin-1 and galectin-9 (Gal-1, Gal-9) in dendritic cells (DCs) from patients with ...
Ana Ramos-Levi, Ana Rodríguez-Muñoz, Ana Serrano, AP Weetman, BS Prabhakar, C Blaser, C Mao, D Cooper, FC Chou, Francisco Sánchez-Madrid, GA Rabinovich, H de la Fuente, Hortensia de la Fuente, ID Mascanfroni, J van der Leij, L Bartalena, L Monney, LV Norling, M Demetriou, M Kanzaki, M Marazuela, M Ruiz-Riol, M Seki, M Seki, MA Toscano, Miguel Sampedro-Nuñez, Mónica Marazuela, N Figueroa-Vega, N Figueroa-Vega, NL Perillo, Roberto González-Amaro, S Katoh, S Leskela, Silke Appel, Susanna Leskela, T Arikawa, T Imaizumi, WM Wiersinga   +37 more
core   +5 more sources

Galectin-9: A Suppressor of Atherosclerosis?

Frontiers in Immunology, 2020
It is no longer controversial that atherosclerosis is a vascular wall chronic inflammatory disease mediated by cells of innate and adaptive immunity. Galectin-9 (Gal-9) seems to be a crucial regulator of T-cell immunity by inducing apoptosis in specific ...
Jian Yu, Ruirui Zhu, Kunwu Yu, Yue Wang, Yan Ding, Yucheng Zhong, Qiutang Zeng   +6 more
doaj   +1 more source

Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers [PDF]

, 2017
Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs).
Khoo, Alan Soo Beng, Liew, Kitson, Peh, Suat Cheng *, Teow, Sin Yeang *   +3 more
core   +1 more source

A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. [PDF]

PLoS ONE, 2010
Approximately 200 million people throughout the world are infected with hepatitis C virus (HCV). One of the most striking features of HCV infection is its high propensity to establish persistence (approximately 70-80%) and progressive liver injury ...
John A Mengshol, Lucy Golden-Mason, Tomohiro Arikawa, Maxwell Smith, Toshiro Niki, Ryan McWilliams, Jessica A Randall, Rachel McMahan, Michael A Zimmerman, Manu Rangachari, Evgenia Dobrinskikh, Pierre Busson, Stephen J Polyak, Mitsuomi Hirashima, Hugo R Rosen   +14 more
doaj   +1 more source

Immunoregulation of Dendritic Cell Subsets by Inhibitory Receptors in Urothelial Cancer. [PDF]

, 2017
Blockade of inhibitory receptors (IRs) overexpressed by T cells can activate antitumor immune responses, resulting in the most promising therapeutic approaches, particularly in bladder cancer, currently able to extend patient survival.
Bohner, P., Cesson, V., Chevalier, M.F., Dartiguenave, F., De Leval, L., Derré, L., Gharbi, D., Gourmaud, J., Jichlinski, P., Legris, A.S., Lhermitte, B., Martin, V., Nardelli-Haefliger, D., Nobile, A., Pieraerts, C., Rotman, S., Speiser, D.E.   +16 more
core   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source