Results 41 to 50 of about 35,521 (207)

Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease [PDF]

, 2013
Background: Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (T(H)1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic
A Sanchez-Fueyo, Akihiro Katayama, AS Levey, Atsuko Nakatsuka, C Zhu, Chigusa Higuchi, F Wang, Hirofumi Makino, J Klibi, J Wada, J Wada, JA Mengshol, Jun Eguchi, Jun Wada, K Igawa, Kazutoshi Murakami, Kentaro Inoue, M Baba, M Kanzaki, Mayu Watanabe, Motoko Kanzaki, Nobuyuki Miyatake, O Tureci, P Jayaraman, S de Kivit, S Matsuo, S Sehrawat, Sanae Teshigawara, SH Barondes, T Imaizumi, Takahiro Terami, WJ Chirico, Y Tsuchiyama, Yuko Kurose   +33 more
core   +2 more sources

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes. [PDF]

, 2011
Carbohydrate derivatisation and glycocluster formation are both known to enhance avidity for lectin binding. Using a plant toxin and human adhesion/growth-regulatory lectins (inter- and intrafamily comparisons) the effect of their combination is examined.
André, André, André, André, Cumpstey, Cyrille Grandjean, Dam, Delacour, Fort, Francesco Sansone, François-Moana Gautier, Fulton, Gabius, Galanina, Gautier, Gupta, Hans-Joachim Gabius, Hirabayashi, Jiménez, Kopitz, Krzeminski, Leyden, Oda, Patnaik, Rocco Ungaro, Sabine André, Sanchez-Ruderisch, Sansone, Silvia Bernardi, Sparrow, Sörme, Villalobo, Wu, Wu, Yamazaki   +34 more
core   +3 more sources

A novel monoclonal antibody for detection of galectin-9 in tissue sections: application to human tissues infected by oncogenic viruses

Infectious Agents and Cancer, 2012
Background Galectin-9 is a mammalian lectin which possesses immunosuppressive properties. Excessive production of galectin-9 has been reported in two types of human virus-associated diseases chronic hepatitis C and nasopharyngeal carcinoma associated to ...
Barjon Clément, Niki Toshiro, Vérillaud Benjamin, Opolon Paule, Bedossa Pierre, Hirashima Mitsuomi, Blanchin Stéphanie, Wassef Michel, Rosen Hugo R, Jimenez Anne-Sophie, Wei Ming, Busson Pierre   +11 more
doaj   +1 more source

Graves' disease is associated with a defective expression of the immune regulatory molecule galectin-9 in antigen-presenting dendritic cells [PDF]

, 2015
Introduction Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function of galectin-1 and galectin-9 (Gal-1, Gal-9) in dendritic cells (DCs) from patients with ...
Ana Ramos-Levi, Ana Rodríguez-Muñoz, Ana Serrano, AP Weetman, BS Prabhakar, C Blaser, C Mao, D Cooper, FC Chou, Francisco Sánchez-Madrid, GA Rabinovich, H de la Fuente, Hortensia de la Fuente, ID Mascanfroni, J van der Leij, L Bartalena, L Monney, LV Norling, M Demetriou, M Kanzaki, M Marazuela, M Ruiz-Riol, M Seki, M Seki, MA Toscano, Miguel Sampedro-Nuñez, Mónica Marazuela, N Figueroa-Vega, N Figueroa-Vega, NL Perillo, Roberto González-Amaro, S Katoh, S Leskela, Silke Appel, Susanna Leskela, T Arikawa, T Imaizumi, WM Wiersinga   +37 more
core   +5 more sources

Clinical Significance of Serum Galectin-9 and Soluble CD155 Levels in Patients with Systemic Sclerosis

Journal of Immunology Research, 2018
Signaling through coinhibitory receptors downregulates the immune response to prevent excessive immune activation and maintain optimal immunity and tolerance.
Mami Chihara, Miki Kurita, Yuki Yoshihara, Akihiko Asahina, Koichi Yanaba   +4 more
doaj   +1 more source

Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers [PDF]

, 2017
Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs).
Khoo, Alan Soo Beng, Liew, Kitson, Peh, Suat Cheng *, Teow, Sin Yeang *   +3 more
core   +1 more source

Immunomodulator Galectin-9 is Increased in Blood and Skin of Patients with Bullous Pemphigoid

Acta Dermato-Venereologica, 2021
Massive recruitment of eosinophils into the dermis is a hallmark of bullous pemphigoid pathogenesis. Identifying the chemoattractant(s) guiding eosinophils into the skin in bullous pemphigoid is a prerequisite to thera­peutic targeting of eosinophil ...
Jasper Pruessmann, Wiebke Pruessmann, Maike M. Holtsche, Beke Linnemann, Christoph M. Hammers, Nina van Beek, Detlef Zillikens, Enno Schmidt, Christian D. Sadik   +8 more
doaj   +1 more source

Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937 [PDF]

, 2016
In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells).
Albarracín, Leonardo Miguel, Aso, Hisashi, Ikeda-Ohtsubo, Wakako, Kanmani, Paulraj, Kano, Hiroshi, Kitazawa, Haruki, Kobayashi, Hisakazu, Kober, Humayun A.K.M., Makino, Seiya, Nochi, Tomonori, Ohkawara, Sou, Saito, Tadao, Sato, Nana, Suda, Yoshihito, Villena, Julio Cesar   +14 more
core   +1 more source

Galectin-9: A Suppressor of Atherosclerosis?

Frontiers in Immunology, 2020
It is no longer controversial that atherosclerosis is a vascular wall chronic inflammatory disease mediated by cells of innate and adaptive immunity. Galectin-9 (Gal-9) seems to be a crucial regulator of T-cell immunity by inducing apoptosis in specific ...
Jian Yu, Ruirui Zhu, Kunwu Yu, Yue Wang, Yan Ding, Yucheng Zhong, Qiutang Zeng   +6 more
doaj   +1 more source

A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. [PDF]

PLoS ONE, 2010
Approximately 200 million people throughout the world are infected with hepatitis C virus (HCV). One of the most striking features of HCV infection is its high propensity to establish persistence (approximately 70-80%) and progressive liver injury ...
John A Mengshol, Lucy Golden-Mason, Tomohiro Arikawa, Maxwell Smith, Toshiro Niki, Ryan McWilliams, Jessica A Randall, Rachel McMahan, Michael A Zimmerman, Manu Rangachari, Evgenia Dobrinskikh, Pierre Busson, Stephen J Polyak, Mitsuomi Hirashima, Hugo R Rosen   +14 more
doaj   +1 more source