Results 11 to 20 of about 42,532 (255)
Galectin-1 in myelin repair [PDF]
Oncotarget, 2016 Galectin-1 (Gal-1) is a member of a highly conserved family of animal lectins which binds to the common disaccharide [Galβ(1-4)-GlcNAc] on both N- and O-glycans decorating cell surface glycoconjugates.
Pasquini, Laura Andrea +2 more
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Galectin-1 in Obesity and Type 2 Diabetes
Metabolites, 2022 Galectin-1 is a carbohydrate-binding protein expressed in many tissues. In recent years, increasing evidence has emerged for the role of galectin-1 in obesity, insulin resistance and type 2 diabetes. Galectin-1 has been highly conserved through evolution
Emanuel Fryk +2 more
doaj +1 more source
iScience, 2023 Summary: Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells.
Asha M. Rudjord-Levann +15 more
doaj +1 more source
Galectin-1 for Neuroprotection? [PDF]
Immunity, 2012 Classically activated microglia (M1) are believed to play a key role in neuronal degeneration in multiple sclerosis (MS). In this issue of Immunity, Starossom et al. (2012) show that Galectin-1 exerts a neuroprotective function through glycosylation-dependent inactivation with M1 cells.
Nonaka, Motohiro, Fukuda, Minoru
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Cell Death and Disease, 2021 Galectin-1 contains a carbohydrate-recognition domain (CRD) as a member of the lectin family. Here, we investigated whether galectin-1 regulates adipogenesis and lipid accumulation.
Jung-Hwan Baek +4 more
doaj +1 more source
Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer. [PDF]
PLoS ONE, 2015 Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in cancer. Galectin-1, -3 and -9 have become the focus of different research groups, but their expression and function in ...
Simone Punt +5 more
doaj +1 more source
Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions [PDF]
Nature Communications, 2015 Galectins are glycan-binding proteins involved in various biological processes including cell/cell interactions. During B-cell development, bone marrow stromal cells secreting galectin-1 (GAL1) constitute a specific niche for pre-BII cells. Besides binding glycans, GAL1 is also a pre-B cell receptor (pre-BCR) ligand that induces receptor clustering ...
Bonzi, Jeremy +9 more
openaire +3 more sources
Chemokines modulate glycan binding and the immunoregulatory activity of galectins
Communications Biology, 2021 Sanjurjo et al investigate the role of galectins in immunomodulation, reporting that chemokines can control galectin immunomodulatory function through a mechanism involving galectin-chemokine binding pairs.
Lucía Sanjurjo +12 more
doaj +1 more source
Фундаментальная и клиническая медицина, 2021 Aim. To study the expression of galectin-1 and galectin-3 in colon cancer and the levels of these proteins in the peripheral blood in relation to the differentiation, invasion, and metastatic dissemination.Materials and Methods.
Yu. V. Kolobovnikova +8 more
doaj +1 more source
Galectin-1 promotes human neutrophil migration [PDF]
Glycobiology, 2012 An important step of innate immune response is the recruitment of polymorphonuclear leukocytes (PMN) to injured tissues through chemotactic molecules. Galectins, a family of endogenous lectins, participate in numerous functions such as lymphoid cell migration, homing, cell-cell and cell-matrix interactions.
Constance, Auvynet +6 more
openaire +2 more sources