Results 61 to 70 of about 43,144 (243)

The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1 [PDF]

, 2014
CD69 is involved in immune cell homeostasis, regulating the T cell-mediated immune response through the control of Th17 cell differentiation. However, natural ligands for CD69 have not yet been described.
Bonay, Pedro, Cibrián-Vera, Danay, Cruz-Adalia, Aranzazu, Fuente, Hortensia de la, Gutierrez-Gallego, Ricardo, Martín, Pilar, Martínez del Hoyo, Gloria, Navarro, Pilar, Pérez-Hernández, Daniel, Ramirez-Huesca, Marta, Sánchez-Madrid, Francisco, Vázquez, Jesús   +11 more
core   +2 more sources

Galectin-1(L11A) Predicted from a Computed Galectin-1 Farnesyl-Binding Pocket Selectively Inhibits Ras-GTP [PDF]

Cancer Research, 2004
Abstract Ras biological activity necessitates membrane anchorage that depends on the Ras farnesyl moiety and is strengthened by Ras/galectin-1 interactions. We identified a hydrophobic pocket in galectin-1, analogous to the Cdc42 geranylgeranyl-binding cavity in RhoGDI, possessing homologous isoprenoid-binding residues, including the ...
Barak, Rotblat, Hagit, Niv, Sabine, André, Herbert, Kaltner, Hans-Joachim, Gabius, Yoel, Kloog   +5 more
openaire   +2 more sources

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Galectin-1 Regulates RNA Expression and Alternative Splicing of Angiogenic Genes in HUVECs

Frontiers in Bioscience-Landmark, 2023
Background: Angiogenesis is essential for tissue development, and therefore its dysregulation can cause various diseases, including cerebrovascular disease. Galectin-1, encoded by the lectin galactoside-binding soluble-1 gene (LGALS1), has critical roles
Jiajun Wei, Yunfei Wu, Yue Sun, Dong Chen   +3 more
doaj   +1 more source

From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [PDF]

, 2009
Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine moiety have ...
André, Sabine, Gabius, Hans-Joachim, Kojima, Shuji, Kozar, Tibor, Unverzagt, Carlo   +4 more
core   +1 more source

Galectin-1 receptors in different cell types

Journal of Biomedical Science, 2005
Galectins are a family of animal lectins defined by two properties: shared amino acid sequences in their carbohydrate-recognizing domain, and beta-galactoside affinity. A wide variety of biological phenomena are related to galectins, i.e., development, differentiation, morphogenesis, tumor metastasis, apoptosis, RNA splicing, and immunoregulatory ...
Elola, María Teresa, Chiesa, María Elena, Alberti, Alejandra Fernandez, Mordoh, José, Fink, Nilda Esther   +4 more
openaire   +3 more sources

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Galectin-1-Induced Autophagy Facilitates Cisplatin Resistance of Hepatocellular Carcinoma. [PDF]

PLoS ONE, 2016
Hepatocellular carcinoma (HCC) is one of the most common cancers in Taiwan. Although chemotherapy is the primary treatment for HCC patients, drug resistance often leads to clinical failure.
Yu-Chi Su, Goutham Venkata Naga Davuluri, Cheng-Hao Chen, Dong-Che Shiau, Chien-Chin Chen, Chia-Ling Chen, Yee-Shin Lin, Chih-Peng Chang   +7 more
doaj   +1 more source

Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells. [PDF]

, 1995
Thymic epithelial cells play a crucial role in the selection of developing thymocytes. Thymocyte-epithelial cell interactions involve a number of adhesion molecules, including members of the integrin and immunoglobulin superfamilies.
Baum, LG, Delegeane, A, Fukuda, M, Pang, M, Perillo, NL, Seilhamer, JJ, Uittenbogaart, CH, Wu, T   +7 more
core  

Galectin-1 Pulls the Strings on VEGFR2 [PDF]

Cell, 2014
Anti-vascular endothelial growth factor (VEGF) cancer immunotherapy targets angiogenesis but development of resistance in patients is common. In this issue of Cell, Croci et al. identify a complex set of mechanisms by which galectin-1 prolongs cell-surface retention of VEGF receptor 2 (VEGFR2) and stimulates VEGF-independent tumor angiogenesis.
openaire   +2 more sources