Results 111 to 120 of about 4,689,501 (274)

PRELID1 and VDAC3 Coordinate a Senescence‐Like State in Germinal Center B Cells to Promote IL‐7–Driven Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
Colorectal cancer is characterized by an immunosuppressive microenvironment that limits immunotherapy efficacy. We identify a senescence‐like state in germinal center B cells driven by the PRELID1–VDAC3 axis, which promotes IL‐7 secretion, alleviates CD8+ T‐cell exhaustion, and enhances antitumor immunity. Targeting this pathway improves responsiveness
Yuhan Liao, Huimeng Xu, Xinghua Zhuo, Shupeng Hu, Lanhui Huang, Zhe Hao, Jianxiong Chen, Yulu Wang, Jun Zhou   +8 more
wiley   +1 more source

Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis [PDF]

, 2006
Galectin (Gal)-1, an endogenous lectin found at sites of immune privilege, plays a critical role in the regulation of the immune response. Therapeutic administration of Gal-1 or its genetic delivery suppresses chronic inflammation in experimental models ...
Bianco, German Ariel, Ferrero, Mercedes, Juarez, Claudio P., Luna, José Domingo, Muiño, Juan Carlos, Rabinovich, Gabriel A., Romero, Marta D.   +6 more
core   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Non-Digestible Oligosaccharides Can Suppress Basophil Degranulation in Whole Blood of Peanut-Allergic Patients

Frontiers in Immunology, 2018
BackgroundDietary non-digestible oligosaccharides (NDOs) have a protective effect against allergic manifestations in children at risk. Dietary intervention with NDOs promotes the colonization of beneficial bacteria in the gut and enhances serum galectin ...
Simone M. Hayen, Simone M. Hayen, Constance F. den Hartog Jager, Constance F. den Hartog Jager, André C. Knulst, Edward F. Knol, Edward F. Knol, Johan Garssen, Johan Garssen, Linette E. M. Willemsen, Henny G. Otten   +10 more
doaj   +1 more source

Enhanced Immunomodulation in Inflammatory Environments Favors Human Cardiac Mesenchymal Stromal-Like Cells for Allogeneic Cell Therapies [PDF]

, 2019
Rising numbers of patients with cardiovascular diseases and limited availability of donor hearts require new and improved therapy strategies. Human atrial appendage-derived cells (hAACs) are promising candidates for an allogeneic cell-based treatment. In
Diedrichs, Falk, Haag, Marion, Jürchott, Karsten, Seifert, Martina, Sittinger, Michael, Stolk, Meaghan   +5 more
core   +1 more source

Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
Adaptive immunity relies on the efficient recruitment of T cells from the blood into peripheral tissues. However, the current understanding of factor(s) coordinating these events is incomplete.
A. Mansour, Federica Raucci, Mustafa Sevim, A. Saviano, J. Begum, Zhao Zhi, L. Pezhman, S. Tull, F. Maione, A. Iqbal   +9 more
semanticscholar   +1 more source

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, EarlyView.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

Galectin-9 ameliorates Con A-induced hepatitis by inducing CD4(+)CD25(low/int) effector T-Cell apoptosis and increasing regulatory T cell number. [PDF]

PLoS ONE, 2012
BACKGROUND: T cell-mediated liver damage is a key event in the pathogenesis of many chronic human liver diseases, such as liver transplant rejection, primary biliary cirrhosis, and sclerosing cholangitis. We and other groups have previously reported that
Kun Lv, Yingying Zhang, Mengying Zhang, Min Zhong, Qifeng Suo   +4 more
doaj   +1 more source

In chronic spontaneous urticaria, increased Galectin‐9 expression on basophils and eosinophils is linked to high disease activity, endotype‐specific markers, and response to omalizumab treatment

Allergy. European Journal of Allergy and Clinical Immunology
Galectin‐9 (Gal‐9) has been implicated in allergic and autoimmune diseases, but its role and relevance in chronic spontaneous urticaria (CSU) are unclear.
Jiang Ji, Minhui Tang, Yue Zhao, Chuqiao Zhang, Yu Shen, Bin Zhou, Cuiping Liu, M. Maurer, Q. Jiao   +8 more
semanticscholar   +1 more source

Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells

bioRxiv, 2022
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a global economic and health crisis. Recently, plasma levels of galectin-9 (Gal-9), a β-galactoside-binding lectin involved in immune regulation and viral ...
Li Du, M. Bouzidi, A. Gala, F. Deiter, J. Billaud, S. Yeung, Prerna Dabral, Jing Jin, G. Simmons, Zain Y. Dossani, T. Niki, L. Ndhlovu, J. Greenland, S. Pillai   +13 more
semanticscholar   +1 more source