Results 111 to 120 of about 8,950,905 (317)

Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia

Nature Communications, 2022
The incidence of obesity is rising with greater than 40% of the world’s population expected to be overweight or suffering from obesity by 2030. This is alarming because obesity increases mortality rates in patients with various cancer subtypes including ...
Miyoung Lee, Jamie A. G. Hamilton, G. Talekar, Anthony J. Ross, L. Michael, Manali Rupji, Bhakti Dwivedi, Sunil S. Raikar, J. Boss, Christopher D. Scharer, D. Graham, D. DeRyckere, C. Porter, C. Henry   +13 more
semanticscholar   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

A unique role for galectin-9 in angiogenesis and inflammatory arthritis [PDF]

Arthritis Research & Therapy, 2018
Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid. Roles have been proposed for galectins in the regulation of inflammation and angiogenesis.
O’Brien, Martin J, Shu, Qiang, Stinson, W.Alexander, Tsou, Pei-Suen, Ruth, Jeffrey H, Isozaki, Takeo, Campbell, Phillip L, Ohara, Ray A, Koch, Alisa E, Fox, David A, Amin, M. A   +10 more
openaire   +4 more sources

Galectin-9 ameliorates Con A-induced hepatitis by inducing CD4(+)CD25(low/int) effector T-Cell apoptosis and increasing regulatory T cell number. [PDF]

PLoS ONE, 2012
BACKGROUND: T cell-mediated liver damage is a key event in the pathogenesis of many chronic human liver diseases, such as liver transplant rejection, primary biliary cirrhosis, and sclerosing cholangitis. We and other groups have previously reported that
Kun Lv, Yingying Zhang, Mengying Zhang, Min Zhong, Qifeng Suo   +4 more
doaj   +1 more source

Galectin-9 recognizes and exhibits antimicrobial activity toward microbes expressing blood group–like antigens

Journal of Biological Chemistry, 2022
While adaptive immunity recognizes a nearly infinite range of antigenic determinants, immune tolerance renders adaptive immunity vulnerable to microbes decorated in self-like antigens.
Anna V. Blenda, N. Kamili, Shang-Chuen Wu, William F. Abel, Diyoly Ayona, Christian Gerner-Smidt, A. Ho, G. Benian, R. Cummings, C. Arthur, S. Stowell   +10 more
semanticscholar   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Animal lectins as cell adhesion molecules [PDF]

, 1998
Protein-carbohydrate interaction is exploited in cell adhesion mechanisms besides the recognition of peptide motifs. The sugar code thus significantly contributes to the intriguing specificity of cellular selection of binding partners.
Kaltner, H., Stierstorfer, B.
core   +1 more source

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, EarlyView.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha   +2 more
wiley   +1 more source

Overexpression of Galectin-9 in Islets Prolongs Grafts Survival via Downregulation of Th1 Responses

Cell Transplantation, 2013
The differential activation of T helper (Th) cells and production of cytokines contribute to graft rejection or tolerance. In general, the Th1-type cytokines and cytotoxic T-cells are detected consistently in a host who is undergoing rejection, whereas ...
Feng-Cheng Chou, Chih-Chi Kuo, Yen-Ling Wang, Ming-Hong Lin, B. Linju Yen, Deh-Ming Chang, Huey-Kang Sytwu Ph.D.   +6 more
doaj   +1 more source