Results 161 to 170 of about 8,950,905 (317)

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation

, 2013
Human multipotent mesenchymal stromal cells (MSCs) are clinically applied to treat autoimmune diseases and graft-versus-host disease due to their immunomodulatory properties.
Ingo Müller, Gieseke, Friederike, DOMINICI, Massimo, Massimo Dominici, Müller, Ingo, Nikolay Tzaribachev, Bentzien, Frank, Kruchen, Anne, Friederike Gieseke, Tzaribachev, Nikolay, Frank Bentzien, Anne Kruchen   +11 more
core   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

Poly (I:C) increases the expression of galectin 1, 3, 9 and HGF genes in exosomes isolated from human Wharton's jelly mesenchymal stem cells

Heliyon
Background: Mesenchymal stem cells (MSCs) are commonly employed as a powerful tool for the treatment of immune-mediated problems owing to their capacity to regulate the immune system and differentiate into different tissues.
Mehdi Abbaspour, Mehri Ghafourian Boroujerdnia, Mohammad Taher Tahoori, Mojtaba Oraki Kohshour, Mohammad Ghasemi Dehcheshmeh, Sareh Amirzadeh, Afshin Amari   +6 more
doaj   +1 more source

Detection of pancreatic ductal adenocarcinoma with galectin-9 serum levels

, 2020
Pancreatic ductal adenocarcinoma (PDAC) responds poorly to checkpoint blockade, such as anti-CTLA-4 and anti-PD-1. Galectin-9, a β-galactoside-binding lectin, promotes immune suppression through T-cell inhibition, and programming of tolerogenic ...
Reissfelder, Christoph, Kahlert, Christoph, Baier, Stephanie, Seifert, Lena, Anna Tannert, Welsch, Thilo, Christoph Kahlert, Seifert, Adrian M., Aust, Daniela E., Max Heiduk, Heiduk, Max, von Renesse, Janusz, Charlotte Reiche, Tannert, Anna, Weitz, Jürgen, Distler, Marius, Miller, George, Adrian M. Seifert, Christoph Reissfelder, Marius Distler, Stephanie Baier, Thilo Welsch, Lena Seifert, Meinecke, Ann-Christin, Ann-Christin Meinecke, Daniela E. Aust, George Miller, Reiche, Charlotte, Jürgen Weitz, Janusz von Renesse   +29 more
core   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

Survival mechanisms in B lymphoid malignancies and associated therapies

, 2011
PhDThe apoptotic pathway plays critical roles in regulating lymphocyte survival throughout B cell development, maturation and differentiation. The whole process involves clonal expansion. In the normal B lymphocyte population the majority of cells and
Su, Bo
core  

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Immunofluorescent staining of galectin-1, -3 and -9.

, 2015
Representative triple staining image in an FFPE squamous cervical cancer sample containing tumor epithelial cells expressing galectin-1 (A, blue), galectin-3 (B, green) and galectin-9 (C, red) at a 200x magnification.
Victor L. Thijssen (635369), Ekaterina S. Jordanova (160493), Johannes Vrolijk (754218), Arko Gorter (24914), Cornelis D. de Kroon (754219), Simone Punt (754217)   +5 more
core   +1 more source