Results 171 to 180 of about 8,950,905 (317)
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
, 2019 Figure S2. Knockdown or overexpression of Galectin-1 in U251 or U87-MG cells. A. Galectin-1 was knocked down in U251 cell lines by SiRNA1â3. Galectin-1 siRNA2 and siRNA3 significantly reduced Galectin-1expression. B.
Shi Ma (217876) +12 more
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The FEBS Journal, EarlyView.Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang +5 more
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, 2011 Background: A growing body of evidence links macrophage activation and fibrosis to the pathogenesis of heart failure (HF). Galectin-3 is one of the most likely mediators between macrophage activation and myocardial fibrosis.
LIN, YEN-HUNG;LIN, LIAN-YU;WU, YEN-WEN;CHIEN, KUO-LIONG;LEE, CHII-MING;HSU, RON-BIN;CHAO, CHIA-LUN;WANG, SHOEI-SHEN;HSEIN, YENH-CHEN;LIAO, LIN-CHU;HO, YI-LWUN;CHEN, MING-FONG +1 more
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Journal of Diabetes Investigation, EarlyView.Elevated serum galectin‐3 levels are associated with the incidence of T2DM independent of insulin resistance, particularly among non‐obese individuals. There may be a diabetogenic mechanism that is not mediated by obesity or insulin resistance. ABSTRACT Aims/Introduction Although several studies have reported elevated serum galectin‐3 levels in type 2 ...
Harumi Takubo‐Yoshimura +8 more
wiley +1 more source
Journal of Oral Pathology &Medicine, EarlyView.ABSTRACT Background Early‐onset oral squamous cell carcinoma (EO‐OSCC), commonly defined as occurring in individuals under 50 years of age, is increasingly recognized as a potentially distinct clinical subset with differences in exposure patterns and tumor biology compared with conventional oral squamous cell carcinoma (OSCC).
Gennaro Musella +8 more
wiley +1 more source
류마티스 관절염 환자에서 질병의 활성도에 따른 혈장 내 galectin-9 의 농도 및 galectin-3/galectin-9 비의 변화에 대한 전향적 연구
, 2012 Dept. of Medicine/석사Objective: To investigate the utility of serum galectin-9 and ratio of galectin-3/galectin-9 in the evaluation of the disease activity of rheumatoid arthritis (RA).Method: The serum concentration of galectin-3 and galectin-9 from RA ...
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Galectin-3 suppresses mucosal inflammation and reduces disease severity in experimental colitis
, 2017 Galectin-3, a member of the beta-galactoside-binding lectin family, expresses in many different immune cells and modulates broad biological functions including cell adhesion, cell activation, cell growth, apoptosis, and inflammation. However, the role of
許秉寧 +1 more
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Understanding exosomes in regenerative dentistry
Periodontology 2000, EarlyView.Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad +2 more
wiley +1 more source