Results 261 to 270 of about 4,219,302 (284)

Galectin-9 in physiological and pathological conditions

Glycoconjugate Journal, 2002
We first cloned galectin-9 (Gal-9)/ecalectin as a T cell-derived eosinophil chemoattractant. Gal-9 plays a role in not only accumulation but also activation of eosinophils in experimental allergic models and human allergic patients, because Gal-9 induces eosinophil chemoattraction in vitro and in vivo and activates eosinophils in many aspects.
Mitsuomi, Hirashima, Yumiko, Kashio, Nozomu, Nishi, Akira, Yamauchi, Tada-atsu, Imaizumi, Toshiro, Kageshita, Naoki, Saita, Takanori, Nakamura   +7 more
openaire   +2 more sources

A Galectin-9–Driven CD11chigh Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia

Circulation
BACKGROUND: Preeclampsia is a serious disease of pregnancy that lacks early diagnosis methods or effective treatment, except delivery. Dysregulated uterine immune cells and spiral arteries are implicated in preeclampsia, but the mechanistic link remains ...
Yanhong Li, Yifei Sang, Yunjian Chang, Chunfang Xu, Yi-kong Lin, Yao Zhang, PhilipC.N. Chiu, WilliamS.B. Yeung, Haisheng Zhou, Ningzheng Dong, Ling Xu, Jiajia Chen, Weijie Zhao, Lu Liu, Di Yu, Xingxing Zang, Jiangfeng Ye, Jinying Yang, Qingyu Wu, Dajin Li, Ligang Wu, Meirong Du   +21 more
semanticscholar   +1 more source

Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix.

ACS Chemical Biology, 2022
Aberrations in glycan and lectin expression and function represent one of the earliest hallmarks of cancer. Among galectins, a conserved family of β-galactoside-binding lectins, the role of Galectin-9 in immune-tumor interactions is well-established ...
Dharma Pally, Mallar Banerjee, Shahid Hussain, R. Kumar, A. Petersson, Ebba Rosendal, L. Gunnarsson, K. Peterson, H. Leffler, U. Nilsson, R. Bhat   +10 more
semanticscholar   +1 more source

Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment.

Cancer Research
Galectin-9 is a multifaceted regulator of various pathophysiological processes that exerts positive or negative effects in a context-dependent manner.
Chanju Lee, Dahee Yu, Hyung-Seok Kim, Ki Sun Kim, Chi Young Chang, H. Yoon, Su Bin Won, Dae Yeon Kim, Eun Ah Goh, Yong Sun Lee, Jong Bae Park, Sang Soo Kim, Eun Jung Park   +12 more
semanticscholar   +1 more source

Intracellular galectin‐9 activates inflammatory cytokines in monocytes

Genes to Cells, 2009
Whether galectin‐9 plays a role in inflammatory responses remains elusive. The present study was designed to determine the role of intracellular galectin‐9 in activation of inflammatory cytokine genes in human monocytes. Galectin‐9 expression vector pBKCMV3‐G9 was transiently co‐transfected into THP‐1 monocytic cells along with luciferase reporters ...
Ai, Matsuura, Junichi, Tsukada, Takamitsu, Mizobe, Takehiro, Higashi, Fumihiko, Mouri, Rena, Tanikawa, Akira, Yamauchi, Mitsuomi, Hirashima, Yoshiya, Tanaka   +8 more
openaire   +2 more sources

Galectin-9 in non-small cell lung cancer

Lung Cancer, 2019
Lung cancer has the highest incidence and fatality among all cancers. Our research analyzed the expression of galectin-9 on non-small cell lung cancer (NSCLC) tumor cells and tumor infiltrating lymphocytes (TILs).We analyzed the expression level of galectin-9 protein in 136 NSCLC primary tumor samples by immunohistochemistry (IHC).We tested 136 ...
Yayi He, Keyi Jia, Rafal Dziadziuszko, Sha Zhao, Xiaoshen Zhang, Juan Deng, Hao Wang, Fred R. Hirsch, Caicun Zhou   +8 more
openaire   +2 more sources

Genomic Structure of Galectin-9 Gene

2006
Elucidation of the genomic structure of the first human electrogenic urate transporting protein will facilitate investigation of its pathogenetic relevance in primary hyperuricemia. Seven missense mutations in 6 exons of galectin-9 gene have been identified so far Their functional consequences remain to be established.
Juergen Graessler, Folker Spitzenberger, Anett Graessler, Birgit Parpart, Eberhard Kuhlische, Steffi Kopprasch, Hans-Egbert Schroeder   +6 more
openaire   +1 more source

Natural Autoantibody to Galectin-9 in Normal Human Sera

Journal of Clinical Immunology, 1999
Antibodies to certain self-antigens are detected in normal individuals as well as in patients with autoimmune diseases. Natural autoantibodies found in normal human sera are thought to act as an immune regulator, a functional controller of specific proteins, or the first-line defense against pathogenic microorganisms.
K, Suk, D Y, Hwang, M S, Lee
openaire   +2 more sources

Interleukin-1β stimulates galectin-9 expression in human astrocytes

Neuroreport, 2001
Galectin-9 is an eosinophil chemoattractant produced by activated T lymphocytes. We have addressed expression of galectin-9 in normal human astrocytes in culture. Expression of galectin-9 mRNA and protein were examined by reverse transcription-polymerase chain reaction (RT-PCR), Western blotting, and immunofluorescent staining.
H, Yoshida, T, Imaizumi, M, Kumagai, K, Kimura, C, Satoh, N, Hanada, K, Fujimoto, N, Nishi, K, Tanji, T, Matsumiya, F, Mori, X F, Cui, W, Tamo, T, Shibata, S, Takanashi, K, Okumura, T, Nakamura, K, Wakabayashi, M, Hirashima, Y, Sato, K, Satoh   +20 more
openaire   +2 more sources

Galectin-9 in tumor biology: A jack of multiple trades

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2013
Galectin family members have been shown to exert multiple roles in the context of tumor biology. Several recent findings support a similar multi-faceted role for galectin-9. Galectin-9 expression is frequently altered in cancer as compared to normal tissues.
Heusschen, Roy, Griffioen, Arjan, Thijssen, Victor   +2 more
openaire   +4 more sources