Results 271 to 280 of about 8,950,905 (317)

Association of Galectin-9 with Eosinophil Apoptosis

International Archives of Allergy and Immunology, 2002
<i>Background:</i> There is no information whether galectin-9 (a novel eosinophil chemoattractant) was associated with pathogenesis of eosinophilic disorders. <i>Methods: </i>We assessed the expression of galectin-9 with imunostaining and in situ hybridization both in the lesion of angiolymphoid hyperplasia with eosinophilia ...
Naoki, Saita, Eisuke, Goto, Taro, Yamamoto, Isamu, Cho, Kaori, Tsumori, Hirotsugu, Kohrogi, Keishi, Maruo, Tomomichi, Ono, Motohiro, Takeya, Yumiko, Kashio, Kazuhiro, Nakamura, Mitsuomi, Hirashima   +11 more
openaire   +2 more sources

Galectin-9 in tumor biology: A jack of multiple trades

Biochimica Et Biophysica Acta: Reviews on Cancer, 2013
Galectin family members have been shown to exert multiple roles in the context of tumor biology. Several recent findings support a similar multi-faceted role for galectin-9. Galectin-9 expression is frequently altered in cancer as compared to normal tissues.
Roy Heusschen, Arjan W Griffioen, VÍCTOR L Thijssen   +2 more
exaly   +5 more sources

Galectin-9 in physiological and pathological conditions

Glycoconjugate Journal, 2002
We first cloned galectin-9 (Gal-9)/ecalectin as a T cell-derived eosinophil chemoattractant. Gal-9 plays a role in not only accumulation but also activation of eosinophils in experimental allergic models and human allergic patients, because Gal-9 induces eosinophil chemoattraction in vitro and in vivo and activates eosinophils in many aspects.
Mitsuomi, Hirashima, Yumiko, Kashio, Nozomu, Nishi, Akira, Yamauchi, Tada-atsu, Imaizumi, Toshiro, Kageshita, Naoki, Saita, Takanori, Nakamura   +7 more
openaire   +2 more sources

Galectin-9 and PD-L1 antibody blockade combination therapy inhibits tumour progression in pancreatic cancer.

Immunotherapy, 2023
Background: The study aimed to evaluate the effect of a galectin-9 and PD-L1 combined blockade in pancreatic ductal adenocarcinoma (PDAC). Methods: The expression of galectin-9 and PD-L1 was analyzed in PDAC.
Enliang Li, Jian Xu, Qi Chen, Xiaozhen Zhang, Xingyuan Xu, T. Liang   +5 more
semanticscholar   +1 more source

Identification of Galectin 9 and its antibacterial function in yellow drum (Nibea albiflora).

Fish and Shellfish Immunology, 2023
Galectins are a family of evolutionarily conserved lectins that contain carbohydrate recognition domains (CRDs) specifically recognizing β-galactoside. Galectin-9 plays a crucial role in various biological processes during pathogenic infections.
Shuai Luo, Baolan Wu, Qiaoying Li, Wanbo Li, Zhiyong Wang, Fang Han, Qing Song   +6 more
semanticscholar   +1 more source

Galectin-9 promotes colon cancer development by polarizing macrophages toward the M2 phenotype.

Cancer Genetics
Galectin-9 plays multiple roles in various tumors and exerts immune regulation within the tumor microenvironment. It is closely associated with tumor prognosis. This study aimed to analyze the expression of galectin-9 in the colon tumor microenvironment.
Jun Zhang, Yang Xu, Xiao Han, Yan Gao, Zhanbo Wei, Xu Sun   +5 more
semanticscholar   +1 more source

Serum level of galectin-9 as a potential biomarker for high risk of malignancy in dermatomyositis.

Rheumatology, 2023
OBJECTIVES Galectin-9, as immune checkpoint protein, plays a role in regulating autoimmunity and tumour immunity. Therefore, we explored the pathophysiological link between galectin-9 and malignancy in cancer-related DM (CRDM). METHODS Serum galectin-9
Yanting Shih, Shile Chen, Jie Huang, Yongheng Chen, Zicong Zhu, Qian Zhao, Xiaoqing Zhao, Feng Xue, J. Xiang, Xiao-song Chen, Xue-wen Zhu, M. Pan, Jun Wu, Jie Zheng, Hao Li, Hua Cao   +15 more
semanticscholar   +1 more source

A Galectin-9–Driven CD11chigh Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia

Circulation
BACKGROUND: Preeclampsia is a serious disease of pregnancy that lacks early diagnosis methods or effective treatment, except delivery. Dysregulated uterine immune cells and spiral arteries are implicated in preeclampsia, but the mechanistic link remains ...
Yanhong Li, Yifei Sang, Yunjian Chang, Chunfang Xu, Yi-kong Lin, Yao Zhang, PhilipC.N. Chiu, WilliamS.B. Yeung, Haiying Zhou, Ningzheng Dong, Ling Xu, Jiajia Chen, Weijie Zhao, Lu Liu, Di Yu, Xingxing Zang, Jiangfeng Ye, Jinying Yang, Qingyu Wu, Dajin Li, Ligang Wu, Meirong Du   +21 more
semanticscholar   +1 more source

Expression of Galectin-9-related immune checkpoint receptors in B-cell acute lymphoblastic leukemia

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Exhausted CD8+ T-cells over-express immune checkpoint receptors (ICRs), which interact with their ligands on malignant cells. However, some ICRs have been reported to be expressed on both T-cells and tumor cells, including V-domain ...
Armin Akbar, Hossein Asgarian-Omran, R. Valadan, M. Dindarloo, Ahmad Najafi, Amir Kahrizi, Arash Poursheikhani, Hossein Karami, Mohammad Naderi, S. Sabeti, Mohsen Tehrani   +10 more
semanticscholar   +1 more source

Molecular characterization and functional study of a galectin-9 from a teleost fish, Boleophthalmus pectinirostris.

Fish and Shellfish Immunology, 2023
Galectin-9, a tandem-repeat galectin, plays an important role in the regulation of innate immune response against various microbial infections. Here, galectin-9 from mudskipper (Boleophthalmus pectinirostris) was identified and named as BpGal-9. Putative
Yong-Fei Zhu, Yi-Fan Hu, Chang-hong Li, Li Nie, Jiong Chen   +4 more
semanticscholar   +1 more source