Results 281 to 290 of about 8,950,905 (317)

Examining the Impact of Galectin-9 on Latent HIV Transcription

2022
The β-galactoside-binding protein Galectin-9 (Gal-9) functions as a double-edged sword during HIV infection. On the one hand, Gal-9 can reactivate HIV latently infected cells, the main barrier to achieving HIV eradication, making them visible to immune clearance.
Opeyemi S, Adeniji, Leila B, Giron, Mohamed, Abdel-Mohsen   +2 more
openaire   +2 more sources

Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment.

Cancer Research
Galectin-9 is a multifaceted regulator of various pathophysiological processes that exerts positive or negative effects in a context-dependent manner.
Chanju Lee, Dahee Yu, Hyung-Seok Kim, Ki Sun Kim, Chi Young Chang, H. Yoon, Su Bin Won, Dae Yeon Kim, Eun-Ah Goh, Y. Lee, Jong Bae Park, Sang Soo Kim, Eun Jung Park   +12 more
semanticscholar   +1 more source

Immunomodulation by galectin-9: Distinct role in T cell populations, current therapeutic avenues and future potential.

Cellular Immunology
Galectins, glycan-binding proteins, have been identified as critical regulators of the immune system. Recently, Galectin-9 (Gal-9) has emerged as biomarker that correlates with disease severity in a range of inflammatory conditions.
Eva M. Gossink, P. Coffer, Alessandro Cutilli, C. Lindemans   +3 more
semanticscholar   +1 more source

Galectin-9 and Tim-3 are upregulated in response to microglial activation induced by the peptide Amyloid-β (25-35).

Neuropeptides
Galectins are a group of β-galactoside-binding lectins associated with regulating immunological response. In the brains of AD patients and 5xFAD (familial AD) mice, galectin-3 (Gal-3) was highly upregulated and found to be expressed in microglia ...
Eleazar Ramírez Hernández, Luis Fernando Hernández Zimbrón, Emmanuel Segura Pérez, José Luis Sánchez Salgado, Mohamed Ali Pereyra Morales, Edgar Zenteno   +5 more
semanticscholar   +1 more source

Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target

Blood Cancer Journal
Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a paradigm of immune tumor microenvironment (TME) contribution to disease onset, progression, and heterogenous clinical outcome.
Cèlia Dobaño-López, J. G. Valero, F. Araujo-Ayala, F. Nadeu, F. Gava, Carla Faria, Marine Norlund, R. Morin, Pascale Bernes-Lasserre, F. Arenas, M. Grau, Cristina López, I. López-Oreja, N. Serrat, Ares Martínez-Farran, Lluís Hernández, Heribert Playa-Albinyana, Rubén Giménez, S. Beá, E. Campo, Jean-Michel Lagarde, A. López-Guillermo, L. Magnano, D. Colomer, C. Bezombes, P. Pérez-Galán   +25 more
semanticscholar   +1 more source

Natural Autoantibody to Galectin-9 in Normal Human Sera

Journal of Clinical Immunology, 1999
Antibodies to certain self-antigens are detected in normal individuals as well as in patients with autoimmune diseases. Natural autoantibodies found in normal human sera are thought to act as an immune regulator, a functional controller of specific proteins, or the first-line defense against pathogenic microorganisms.
K, Suk, D Y, Hwang, M S, Lee
openaire   +2 more sources

Genomic Structure of Galectin-9 Gene

2006
Elucidation of the genomic structure of the first human electrogenic urate transporting protein will facilitate investigation of its pathogenetic relevance in primary hyperuricemia. Seven missense mutations in 6 exons of galectin-9 gene have been identified so far Their functional consequences remain to be established.
Juergen Graessler, Folker Spitzenberger, Anett Graessler, Birgit Parpart, Eberhard Kuhlische, Steffi Kopprasch, Hans-Egbert Schroeder   +6 more
openaire   +1 more source

Galectin-9 in non-small cell lung cancer

Lung Cancer, 2019
Lung cancer has the highest incidence and fatality among all cancers. Our research analyzed the expression of galectin-9 on non-small cell lung cancer (NSCLC) tumor cells and tumor infiltrating lymphocytes (TILs).We analyzed the expression level of galectin-9 protein in 136 NSCLC primary tumor samples by immunohistochemistry (IHC).We tested 136 ...
Yayi He, Keyi Jia, Rafal Dziadziuszko, Sha Zhao, Xiaoshen Zhang, Juan Deng, Hao Wang, Fred R. Hirsch, Caicun Zhou   +8 more
openaire   +2 more sources

Intracellular galectin‐9 activates inflammatory cytokines in monocytes

Genes to Cells, 2009
Whether galectin‐9 plays a role in inflammatory responses remains elusive. The present study was designed to determine the role of intracellular galectin‐9 in activation of inflammatory cytokine genes in human monocytes. Galectin‐9 expression vector pBKCMV3‐G9 was transiently co‐transfected into THP‐1 monocytic cells along with luciferase reporters ...
Ai, Matsuura, Junichi, Tsukada, Takamitsu, Mizobe, Takehiro, Higashi, Fumihiko, Mouri, Rena, Tanikawa, Akira, Yamauchi, Mitsuomi, Hirashima, Yoshiya, Tanaka   +8 more
openaire   +2 more sources

[Serum galectin-9 in cervical cancer].

Zhonghua yi xue za zhi, 2009
To investigate the expression level of Galectin-9 (Gal-9) in the serum of cervical cancer patients and analyze the clinic significance of it.Collected sera from 29 patients with cervical cancer, 45 patients with cervical inter-epithelial lesion (CIN) and 26 normal females. Determination of Gal-9 was performed by ELISA, and in the group of patients with
Mei-yan, Liang, Yan-ming, Lu, Yao, Zhang, Shu-lan, Zhang   +3 more
openaire   +1 more source