Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9-associated depletion of gamma delta and mucosal-associated invariant T cells in Long COVID with ME/CFS. [PDF]
Shahbaz S +6 more
europepmc +1 more source
Galectin-9 induces IL-1β production as a key inflammatory cytokine in the acute myeloid leukemia cell line (U937). [PDF]
Behranvand N +6 more
europepmc +1 more source
Genome-wide CRISPR screen identifies IRF1 and TFAP4 as transcriptional regulators of Galectin-9 in T cell acute lymphoblastic leukemia. [PDF]
Wiggers CRM +11 more
europepmc +1 more source
Galectin-9 and Tim-3 in gastric cancer: a checkpoint axis driving T cell exhaustion and Treg-mediated immunosuppression independently of anti-PD-1 blockade. [PDF]
Hill CN +8 more
europepmc +1 more source
Galectin 9 rescues the inducibility of IL-10 expression in regulatory B cells of patients with food allergy. [PDF]
Huang H +7 more
europepmc +1 more source
TIM-3/Galectin-9 Immune Axis in Colorectal Cancer in Relation to KRAS, NRAS, BRAF, PIK3CA, AKT1 Mutations, MSI Status, and the Cytokine Milieu. [PDF]
Ochman B +10 more
europepmc +1 more source
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Galectin-9 as a biomarker of disease severity.
Cellular Immunology, 2021Galectin-9 (Gal-9) is a β-galactoside binding lectin known for its immunomodulatory role in various microbial infections. Gal-9 is expressed in all organ systems and localized in the nucleus, cell surface, cytoplasm and the extracellular matrix.
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Galectin-9 is a target for the treatment of cancer: A patent review.
International Journal of Biological Macromolecules, 2023Galectins, which correspond to a group of proteins capable of recognizing and reversibly binding to β-galactoside carbohydrates, have been the subject of innovation and development of technological products.
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Galectin-9 is a tandem-repeat type galectin with two carbohydrate-recognition domains, and it was first identified as an eosinophil chemoattractant and activation factor. Subsequent studies revealed that galectin-9, similar to other galectins, modulates a variety of biological functions including cell aggregation and adhesion, as well as apoptosis of ...
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