Results 21 to 30 of about 34,736 (209)

Galectin-3 in Cardiovascular Diseases

International Journal of Molecular Sciences, 2020
Galectin-3 (Gal-3) is a β-galactoside-binding protein belonging to the lectin family with pleiotropic regulatory activities and several physiological cellular functions, such as cellular growth, proliferation, apoptosis, differentiation, cellular adhesion, and tissue repair. Inflammation, tissue fibrosis and angiogenesis are the main processes in which
Blanda Valeria, Bracale U. M., Di Taranto M. D., Fortunato G.   +3 more
openaire   +3 more sources

Activation of Galectin-3 (LGALS3) Transcription by Injurious Stimuli in the Liver Is Commonly Mediated by BRG1

Frontiers in Cell and Developmental Biology, 2019
Galectin-3 (encoded by LGALS3) is a glycan-binding protein that regulates a diverse range of pathophysiological processes contributing to the pathogenesis of human diseases. Previous studies have found that galectin-3 levels are up-regulated in the liver
Zilong Li, Fangqiao Lv, Congxin Dai, Qiong Wang, Chao Jiang, Mingming Fang, Mingming Fang, Yong Xu, Yong Xu   +8 more
doaj   +1 more source

The two endocytic pathways mediated by the carbohydrate recognition domain and regulated by the collagen-like domain of galectin-3 in vascular endothelial cells. [PDF]

PLoS ONE, 2012
Galectin-3 plays an important role in endothelial morphogenesis and angiogenesis. We investigated the endocytosis of galectin-3 in human vascular endothelial cells and showed that galectin-3 could associate with and internalized into the cells in a ...
Xiaoge Gao, Dan Liu, Yuying Fan, Xinzhi Li, Huiting Xue, Yingyun Ma, Yifa Zhou, Guihua Tai   +7 more
doaj   +1 more source

Macrophage-derived galectin-3 contributes to pyroptosis, apoptosis and necroptosis through TLR4/MyD88/NF-κB/NLRP3 during atherosclerosis. [PDF]

Clin Transl Med
Pyroptosis, apoptosis and necroptosis of macrophages occur concurrently during atherosclerosis. Galetein‐3 and NLRP3 are highly expressed in atherosclerotic lesions. Galectin‐3 is principally expressed in macrophages within atherosclerotic plaques. Galectin‐3 interacts with NLRP3, activates TLR4/MyD88/NF‐κB/NLRP3 signal axis, and promotes PANoptosis ...
Yuan Z, Li H, Ruan BX, Huang H, Li Y, Wang J.   +5 more
europepmc   +2 more sources

Galectin-3 Modulates Experimental Colitis [PDF]

Digestion, 2015
Background: We recently identified galectin-3 (gal-3) as a new and strong fibroblast activator produced by colonic epithelial cells. Very little is known about the influence of gal-3 in inflammatory bowel disease. We, therefore, investigated the impact of gal-3 on dextran sodium sulfate (DSS)-induced colitis in a mouse model.
Lippert, Elisabeth, Stieber-Gunckel, Manuela, Dunger, Nadja, Falk, Werner, Obermeier, Florian, Kunst, Claudia   +5 more
openaire   +3 more sources

Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1).

PLoS ONE, 2011
BackgroundGalectin-3 is known to regulate cancer metastasis. However, the underlying mechanism has not been defined. Through the DNA microarray studies after galectin-3 silencing, we demonstrated here that galectin-3 plays a key role in up-regulating the
Seok-Jun Kim, Ji-Young Shin, Kang-Duck Lee, Young-Ki Bae, Il-Ju Choi, Seok Hee Park, Kyung-Hee Chun   +6 more
doaj   +1 more source

Prognostic Significance of Galectin-1 but Not Galectin-3 in Patients With Lung Adenocarcinoma After Radiation Therapy

Frontiers in Oncology, 2022
IntroductionTo investigate the role of tumor galectin-1 and galectin-3 in patients with lung adenocarcinoma after definitive radiation therapy.MethodsA total of 41 patients with localized lung adenocarcinoma undergoing thoracic radiation therapy without ...
Chun-Chieh Huang, Chun-Chieh Huang, I-Chieh Chuang, Yu-Li Su, Hao-Lun Luo, Ya-Chun Chang, Ya-Chun Chang, Jo-Ying Chen, Chang-Chun Hsiao, Chang-Chun Hsiao, Eng-Yen Huang, Eng-Yen Huang   +11 more
doaj   +1 more source

Galectins, antibodies to them and galectin-3 binding protein in systemic lupus erythematosus

Научно-практическая ревматология
The study of galectins is provoked by the search for new biomarkers of activity, clinical manifestations, and disease outcomes of systemic lupus erythematosus (SLE). The presented literature review summarizes the data on the most well-known galectins-1, -
L. V. Kondratyeva, T. V. Popkova, E. L. Nasonov   +2 more
doaj   +1 more source

Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via β-catenin/GSK-3β modulation in colorectal carcinoma.

PLoS ONE, 2013
Multidrug resistance (MDR), an unfavorable factor compromising the treatment efficacy of anticancer drugs, involves the upregulation of ATP binding cassette (ABC) transporters and induction of galectin-3 signaling. Galectin-3 plays an anti-apoptotic role
Yung-Kuo Lee, Tsung-Hsien Lin, Chuan-Fa Chang, Yu-Li Lo   +3 more
doaj   +1 more source

Galectin-3 and cancer stemness [PDF]

Glycobiology, 2018
Over the last few decades galectin-3, a carbohydrate binding protein, with affinity for N-acetyllactosamine residues, has been unique due to the regulatory roles it performs in processes associated with tumor progression and metastasis such as cell proliferation, homotypic/heterotypic aggregation, dynamic cellular transformation, migration and invasion,
Pratima, Nangia-Makker, Victor, Hogan, Avraham, Raz   +2 more
openaire   +2 more sources