Results 51 to 60 of about 34,736 (209)

The role of galectin-3 and galectin-3–binding protein in venous thrombosis [PDF]

Blood, 2015
Key PointsWe determined the location of gal3bp and gal3 and their role in promoting VT and leukocyte/endothelial cell interactions for the first time. Gal3bp and gal3 have the potential to be used as targets for future VT therapies.
Elise P, DeRoo, Shirley K, Wrobleski, Evelyn M, Shea, Ramsey K, Al-Khalil, Angela E, Hawley, Peter K, Henke, Daniel D, Myers, Thomas W, Wakefield, Jose A, Diaz   +8 more
openaire   +2 more sources

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Galectins-1 and-3 Increase in Equine Post-traumatic Osteoarthritis

Frontiers in Veterinary Science, 2018
Galectins are potent regulators of cell adhesion, growth and apoptosis in diverse cell types, including chondrocytes and synovial fibroblasts. Elevations in synovial fluid galectin-3 have been observed in rheumatoid arthritis, juvenile idiopathic ...
Heidi L. Reesink, Alan J. Nixon, Jin Su, Sherry Liu, Ryan M. Sutton, Sabine Mann, Ashlee E. Watts, Ryan P. Peterson   +7 more
doaj   +1 more source

Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose − induced trophoblast cells apoptosis via galectin-3/foxc1 pathway

Molecular Medicine, 2023
Objective This study was to evaluate plasma galectin-3 levels from early pregnancy to delivery and explore the effects of galectin-3 on the function of trophoblast cells under high glucose exposure. Methods The plasma galectin-3 levels were quantified by
Yu Deng, Hongyan Jin, Jie Ning, Dong Cui, Muqiu Zhang, Huixia Yang   +5 more
doaj   +1 more source

PRELID1 and VDAC3 Coordinate a Senescence‐Like State in Germinal Center B Cells to Promote IL‐7–Driven Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
Colorectal cancer is characterized by an immunosuppressive microenvironment that limits immunotherapy efficacy. We identify a senescence‐like state in germinal center B cells driven by the PRELID1–VDAC3 axis, which promotes IL‐7 secretion, alleviates CD8+ T‐cell exhaustion, and enhances antitumor immunity. Targeting this pathway improves responsiveness
Yuhan Liao, Huimeng Xu, Xinghua Zhuo, Shupeng Hu, Lanhui Huang, Zhe Hao, Jianxiong Chen, Yulu Wang, Jun Zhou   +8 more
wiley   +1 more source

Galectin‐3 enhances trastuzumab resistance by regulating cancer malignancy and stemness in HER2‐positive breast cancer cells

Thoracic Cancer, 2022
Purpose The aim of this study was to explore the role of galectin‐3 in human epidermal growth factor receptor 2 (HER2)‐positive breast cancer cells and the potential mechanism.
Yuqiu Chen, Jiawei Xu, Wang Pan, Xiaofan Xu, Xueping Ma, Ya'nan Chu, Lu Wang, Shuyun Pang, Yujiao Li, Bingjie Zou, Guohua Zhou, Jun Gu   +11 more
doaj   +1 more source

Galectin-3 in diabetic patients

Clinical Chemistry and Laboratory Medicine (CCLM), 2014
Galectin-3 is a versatile molecule which exerts several and sometimes opposite functions in various pathophysiological processes. Recently, galectin-3 has gained attention as a powerful predictor of heart failure and mortality, thus becoming a useful prognostic marker in clinical practice.
PUGLIESE, Giuseppe, IACOBINI, carla, RICCI, Carlo, BLASETTI FANTAUZZI, CLAUDIA, MENINI, Stefano   +4 more
openaire   +4 more sources

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Serum apelin and galectin-3 in preeclampsia in Iraq

Hypertension in Pregnancy, 2020
Objective This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE).
Aamal Sattar Taha, Zohreh Zahraei, Hussein Kadhem Al-Hakeim   +2 more
doaj   +1 more source

Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer. [PDF]

PLoS ONE, 2015
Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in cancer. Galectin-1, -3 and -9 have become the focus of different research groups, but their expression and function in ...
Simone Punt, Victor L Thijssen, Johannes Vrolijk, Cornelis D de Kroon, Arko Gorter, Ekaterina S Jordanova   +5 more
doaj   +1 more source