Results 61 to 70 of about 55,687 (218)

LINC00892 inhibits hepatocellular carcinoma progression through SBDS/EIF6‐mediated ribosomal stress and interacting with the immune microenvironment

VIEW, EarlyView.
LINC00892 is lowly expressed in HCC. LINC00892 overexpression induces ribosomal stress via inhibiting SBDS, restrains EIF6 nuclear translocation and activates p53 pathway. LINC00892 overexpression and p53 activation jointly suppress HCC progression. High LINC00892 is associted with infiltration of CD8+ T cells, B cells and macrophages, and associated ...
Xu Zhang, Lina Ma, Juan Ma, Long Hai, Lina Wu, Xueyan Feng, Xiangchun Ding   +6 more
wiley   +1 more source

YTHDF2 in hepatocellular carcinoma: Bridging m6A modification and cancer progression

VIEW, EarlyView.
Abstract YTH N6‐methyladenosine RNAbinding protein F2 (YTHDF2) is an N6‐methyladenosine (m6A) reader protein that mainly regulates the stability of methylated transcripts through mRNA decay. In the liver, YTHDF2 is involved in metabolic homeostasis, oxidative stress responses, and immune regulation.
Sijie Zang, Dongxue Ge, Wanqi Yang, Haobin Shen, Weihong Ge, Li Li, Dayu Chen, Jinglin Wang   +7 more
wiley   +1 more source

Women's and Health Care Professionals' Experiences of Discontinuing Hormone Replacement Therapy (HRT): A Systematic Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Hormone Replacement Therapy (HRT) is used to manage menopausal symptoms, particularly vasomotor symptoms (VMS). HRT prescribing rates are rising, but most women will eventually discontinue. Objectives To explore the experiences of women stopping HRT, why women restart HRT, and the HCPs advising them. Search Strategy Embase, MEDLINE,
Sarah Bunnewell, Sabrina Keating, Jo Parsons, Martha Hickey, Sarah Hillman   +4 more
wiley   +1 more source

Are histological alterations observed in the gallbladder precancerous lesions?

Clinics, 2010
INTRODUCTION: Gallbladder cancer, which is characterized by rapid progression and a poor prognosis, is a complex disease to treat. Unfortunately, little is known currently about its etiology or pathogenesis.
Adriana Lúcia Agnelli Meirelles-Costa, Claudio José Caldas Bresciani, Rodrigo Oliva Perez, Barbara Helou Bresciani, Sheila Aparecida C. Siqueira, Ivan Cecconello   +5 more
doaj   +1 more source

Surgical Appropriateness of Imaging in Acute Cholecystitis: A Danish Audit

Surgical Practice, EarlyView.
ABSTRACT Background Acute cholecystitis is a common surgical condition, most frequently caused by gallstones. Ultrasound is recommended as the first‐line imaging modality, while CT and MRCP are reserved for inconclusive cases or suspected complications. Increasing use of CT in Denmark raises concerns regarding unnecessary radiation exposure. This study
Daniel Bornemann, Tobias Nord Neustrup, Anders Dalgaard Andersen, Sandra Soerensen, Theis Christmas Moeller, Peter Derek Christian Leutscher, Kathrine Holte   +6 more
wiley   +1 more source

Aspartate beta-hydroxylase is a prognostic factor in gallbladder cancer with the function of promoting tumorigenesis and chemoresistance

Frontiers in Endocrinology
AimsGallbladder cancer is characterized by a dismal prognosis, with a limited number of biological markers currently identified for the carcinogenesis, progression and prognosis of gallbladder cancers (GBCs).
Luo Yuan, Huang Yunpeng, Li Xiong, Yu Wen, Wang Yongxiang   +4 more
doaj   +1 more source

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source

Comparison of thymidine phosphorylase expression and prognostic factors in gallbladder and bile duct cancer

BMC Cancer, 2010
Background Biliary tract cancers have limitations in information about different location-related pathogenesis and clinico-pathological characteristics.
You Young, Kim Dong-Goo, Chung Eun-Seon, Lee Myung, Won Hye, Hong Tae, Lee In-Seok   +6 more
doaj   +1 more source

Impact of propofol‐based vs. volatile‐based anaesthesia on survival and recurrence after cancer surgery: a systematic review and meta‐analysis of randomised trials

Anaesthesia, EarlyView.
Summary Introduction Choice of peri‐operative anaesthetic technique may influence cancer recurrence, survival and mortality following curative surgery. Conflicting evidence exists on whether propofol‐based anaesthesia improves outcomes over volatile anaesthesia.
Ashmit Daiyan Mustafa, Pavan Shet, Sameen Shadman Sawdagar   +2 more
wiley   +1 more source

Pancreatic Invasion in Distal Cholangiocarcinoma Is a Poor Prognostic Factor: A New Approach Integrating Tumor Depth of Invasion

ANZ Journal of Surgery, EarlyView.
This study revealed that the combination of DOI > 4 mm and pancreatic invasion is an independent predictor of poor prognosis in distal cholangiocarcinoma. Incorporating pancreatic invasion into DOI‐based classification may improve prognostic assessment beyond the current AJCC staging system.
Hirokazu Ogasawara, Tadashi Yoshizawa, Kenta Ogasawara, Daiki Kasai, Shintaro Goto, Hayato Nagase, Norihisa Kimura, Keinosuke Ishido, Hiroshi Kijima, Kenichi Hakamada   +9 more
wiley   +1 more source