Results 71 to 80 of about 55,687 (218)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

Controversial points in the surgical treatment of gallbladder cancer with delayed diagnoses [PDF]

Waike lilun yu shijian
Gallbladder cancer with delayed diagnoses, as a malignant tumor diagnosed intraoperatively or postoperatively incidentally in benign gallbladder diseases, radical surgical treatment is its core treatment, and the necessity of re-operation, timing of ...
LE Sen, ZUO Yue, DENG Zhengdong, WANG Jianming
doaj   +1 more source

Assessment of MRD and Longitudinal Monitoring of Post‐Surgery Biliary Tract Cancer With a Customized ctDNA Panel

Cancer Science, EarlyView.
A customized panel was established for BTC MRD detection. Preoperative ctDNA detection was associated with pathological stage and poorer RFS and OS. Longitudinal monitoring detected ctDNA before radiological recurrence in 72.7% of patients, with a median lead time of 77 days, supporting ctDNA as a complementary prognostic biomarker with CA19‐9 ...
Yoshihito Shinohara, Toru Nakamura, Yasutoshi Kimura, Takeshi Murakami, Shigeyuki Kojima, Toshikazu Yamaguchi, Kanako C. Hatanaka, Ryo Okazaki, Yosuke Kitayama, Keita Fukuda, Fabio Pittella‐Silva, Yusuke Nakamura, Satoshi Hirano, Siew‐Kee Low   +13 more
wiley   +1 more source

Diagnosis and management of gallbladder cancer

North American Journal of Medical Sciences, 2012
Gallbladder cancer (GBC) is a rather uncommon disease, but at the time when it gives symptoms it has usually reached no longer curable stage. Therefore, all attempts must be made to make the diagnosis earlier to have better opportunity for cure. The author searched PubMed, and reviewed literatures on diagnoses and treatment of GBC.
openaire   +3 more sources

Choledochoduodenal fistula presenting with pneumobilia in a patient with gallbladder cancer: a case report

Journal of Medical Case Reports, 2012
Introduction Spontaneous biliary tract fistulas are rare entities. Most of them are associated with long-standing gallstones (especially common bile duct stones, or recurrent biliary tract infections), some with more uncommon diseases such as gallbladder
Dadzan Elham, Akhondi Hossein
doaj   +1 more source

Gallbladder Cancer

Annals of Surgery, 2005
intervention was wrong in 62% of their patients. In 50% of the patients, the initial diagnosis was a benign biliary disorder such as biliary colic (24%), acute colicystitis (12%), or choledocholithiasis (5%). In another 12% of patients, the gallbladder cancer was confused with a perihilar cholangiocarcinoma. As a result, 31% of the patients underwent a
openaire   +3 more sources

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

Chemotherapy combined with pembrolizumab in advanced gallbladder cancer with subsequent radical resection: A case report

iLIVER
Gallbladder cancer is often diagnosed at an advanced stage, preventing radical surgical intervention. Combined with its highly aggressive nature, this results in a generally poor prognosis.
Yongjie Hu, Yongpeng Wei, Xinbo Liu, Li Shen, Yu Wang, Jianyong Yuan   +5 more
doaj   +1 more source

Effectiveness of Adding GLP‐1 Receptor Agonists to SGLT2 Inhibitor Therapy in Chronic Kidney Disease: A Population Based Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Individually, sodium–glucose co‐transporter‐2 inhibitors (SGLT2i) and glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have been shown to reduce major kidney and cardiovascular events in patients with chronic kidney disease (CKD). However, evidence supporting combined GLP‐1RA and SGLT2i therapy in this population remains limited.
Hussain Salim, Shaheer Qureshi, Gaurav S. Gulsin, Habib R. Khan, Saad Ahmed Waqas, Gerry P. McCann, Amit Garg, Mohammed Shurrab, Kamlesh Khunti, Muhammad Rashid   +9 more
wiley   +1 more source