Results 31 to 40 of about 1,344 (259)
Sciences du Jeu, 2023 According to Paulo Freire (1971), conscientization is a process of collective learning aimed at bringing out a critical reflection through praxis in individuals.
Homo Ludens
doaj +1 more source
Spreadable Jams: Implementing Social Scholarship through Remodeled Game Jam Paradigms
KULA, 2019 Game design communities often come together during ‘Game Jams,’ open social events in which game makers creatively respond to a design provocation by generating numerous prototypes over a short period of time.
Jon Saklofske
doaj +1 more source
Pendampingan Pembelajaran Bahasa Inggris bagi Anak Usia Dini Melalui Game
Madaniya, 2023 Salah satu cara yang bisa dilakukan agar tidak terasa asing dengan Bahasa Inggris tersebut yakni pengenalan Bahasa Inggris sejak dini. Hal tersebut bertujuan untuk mencangkan generasi emas, tidak hanya itu dengan mengenalkan Bahasa Inggris sejak dini ...
Jusriati Jusriati +4 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
PENGARUH KEERGONOMISAN STASIUN KOMPUTER GAME NET PADA RISIKO GANGGUAN OTOT-RANGKA
J@ti Undip: Jurnal Teknik Industri, 2018 Abstrak Maraknya pengguna online game memicu terjadinya peningkatan jumlah penyedia jasa bermain game net dengan pengguna anak-anak, namun stasiun komputer yang digunakan ditujukan untuk pengguna dewasa.
Yassierli Yassierli +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source