Results 161 to 170 of about 93,041 (352)

Phytochemical Contents and Bioactive Compounds in Widely Consumed Cereals, Legumes, and Vegetables in Abruzzo Region, Italy: A Critical Review

open access: yesFood Safety and Health, EarlyView.
This review aims to collect and identify cereals, legumes, and vegetables mostly consumed in the Abruzzo region from 2020 till now, pointing attention to their biological effects. ABSTRACT The Abruzzo region boasts a wide range of typical food products including cereals, legumes, and vegetables. In this context, they take part in the Mediterranean diet,
Giulia Gentile   +3 more
wiley   +1 more source

Conceptual and organizational barriers to quantitative systems pharmacology modeling of pathophysiological systemic drug hypotheses

open access: yes, 2022
CPT: Pharmacometrics &Systems Pharmacology, Volume 11, Issue 12, Page 1556-1559, December 2022.
Ronald Gieschke, Robert Carr
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

open access: yesBritish Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi   +6 more
wiley   +1 more source

An Intermediate State of the {gamma}-Aminobutyric Acid Transporter GAT1 Revealed by Simultaneous Voltage Clamp and Fluorescence [PDF]

open access: yes, 2000
The rat {gamma}-aminobutyric acid transporter GAT1 expressed in Xenopus oocytes was labeled at Cys74, and at one or more other sites, by tetramethylrhodamine-5-maleimide, without significantly altering GAT1 function.
Farley, Robert A.   +2 more
core   +1 more source

Temporal Profiling of Male Cortical Astrocyte Transcription Predicts Molecular Shifts From Early Development to Aging

open access: yesGlia, EarlyView.
Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain. ABSTRACT Astrocytes are the most abundant glial cell type in the central nervous system (CNS).
Xiaoran Wei   +2 more
wiley   +1 more source

GABA Dysfunction and Its Consequences in Women with Polycystic Ovary Syndrome [PDF]

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul
Background and Objective: The GABA system plays an important role in the development, maturation, and function of gonadotropin-releasing hormone (GnRH)-secreting neurons, as well as in the coordination of reproductive and metabolic signals.
F Motafeghi   +3 more
doaj  

Research progress of neurovascular units involved in ischemic stroke

open access: yesIbrain, EarlyView.
The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang   +4 more
wiley   +1 more source

Research progress on the mechanisms of pain empathy

open access: yesIbrain, EarlyView.
This article is related to the graphical research progress of pain empathy, starting with the description of the pain matrix and mirror neurons. Based on the pain matrix and mirror neurons, pain empathy results from the combined action of brain regions such as the anterior cingulate cortex, insula, prefrontal cortex, and amygdala and regulatory ...
Shuangshuang Liu   +5 more
wiley   +1 more source

Antimicrobial‐associated encephalopathy due to ampicillin

open access: yesClinical Case Reports
Key Clinical Message Because the β‐lactam ring has a molecular structure similar to that of gamma‐aminobutyric acid (GABA) neurotransmitters, it binds to GABA A receptors and inhibits GABAergic transmission, causing AAE.
Naoya Mizutani, Tsuneaki Kenzaka
doaj   +1 more source

Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions

open access: yesIbrain, EarlyView.
Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra   +4 more
wiley   +1 more source

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