Results 111 to 120 of about 12,504 (230)
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease [PDF]
, 2010 Guriqbal S. Basi +51 more
openalex +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.β‐amyloid activates microglia via the TLR/NF‐κB pathway and primes the NLRP3 inflammasome, driving neuroinflammation. β‐asarone counteracts this by activating autophagy, which degrades NLRP3 components and inhibits inflammasome assembly. This reduces IL‐1β maturation, suppresses cytokine release, and alleviates neuronal damage and cognitive deficits in
Zhiwei Xu +6 more
wiley +1 more source
Gamma secretase inhibitors inhibit ovarian cancer development and enhance olaparib’s anti-ovarian cancer activity and its mechanism [PDF]
, 2020 Yao Xiaoxiao, Nan Zheng
openalex +1 more source
Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss
Comprehensive Physiology, Volume 16, Issue 1, February 2026.Female‐specific bone loss in Alzheimer's disease mouse models: There is a significant alteration of bone phenotype during Alzheimer's disease. Using integrated imaging and biological assays, we observed changes in the bone microarchitecture, composition, and function in PSEN K1 and PSEN1/hAPP Tg+ mice, predominantly in the females. ABSTRACT Accelerated
Vidyani Suryadevara +12 more
wiley +1 more source
NOTCH2 gene mutation and gamma-secretase inhibitor in mediating the malignancy of ovarian cancer. [PDF]
Aging (Albany NY), 2023 Wang W +5 more
europepmc +1 more source
The insider's perspective: The intracellular complosome and immune cell dynamics in cancer
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.Intracellular complement (complosome) shapes the tumour immune microenvironment. Complosome's role in cancer is underrecognised yet central to tumour immunity. C3/C5‐driven complosome signals rewire T‐cell activation, fate and metabolism. Complosome activity can promote pro‐tumour immune cell function.
Alexandra Bennion +2 more
wiley +1 more source
Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation
Food Science &Nutrition, Volume 14, Issue 2, February 2026.Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid +7 more
wiley +1 more source