Results 141 to 150 of about 12,504 (230)

Amyloid β—Cholesterol Interplay: Removal of Cholesterol From the Membranes to Catalyze Aggregation and Amyloid Pathology

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
The interplay between the cholesterol metabolism and assembly of Aβ42 (Amyloid beta‐42) peptide in pathological aggregates is considered one of the major molecular mechanisms in the development of Alzheimer's disease (AD). Our combined studies revealed that Aβ42 was capable of removing cholesterol from the membrane at physiologically relevant low ...
Rishiram Baral, Ruan van Deventer, Yuri L. Lyubchenko   +2 more
wiley   +1 more source

Rutin Potentially Binds the Gamma Secretase Catalytic Site, Down Regulates the Notch Signaling Pathway and Reduces Sphere Formation in Colonospheres. [PDF]

Metabolites, 2022
Singh AK, Shuaib M, Prajapati KS, Kumar S.   +3 more
europepmc   +1 more source

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain [PDF]

, 2001
Harry F. Dovey, Varghese John, J. P. Anderson, L. Z. Chen, P. D. S. int Andrieu, Lanlan Fang, Stephen B. Freedman, B. Folmer, Erich Goldbach, Elzbieta J. Holsztynska, Kang Hu, Kelly Johnson‐Wood, S. L. Kennedy, Dora Kholodenko, Jeroen Knops, Lee H. Latimer, M. Lee, Zhengchang Liao, Ivan Lieberburg, Ruth Motter, Linda Mutter, J. Nietz, Kevin P. Quinn, K. L. Sacchi, Peter Seubert, George M. Shopp, Eugene D. Thorsett, Jay S. Tung, Jing Wu, Shao-Hua Yang, Chen Yin, Dale B. Schenk, Patrick C. May, L. Altstiel, Mark H. Bender, Leonard N. Boggs, T. C. Britton, James C. Clemens, Dan L. Czilli, Donna K. Dieckman-McGinty, J. J. Droste, Kimberly S. Fuson, Bruce D. Gitter, Paul A. Hyslop, Edward M. Johnstone, W‐Y. Li, Sharon Little, Thomas E. Mabry, F. DeWolfe Miller, B. Ni, Jeffrey S. Nissen, Warren J. Porter, B D Potts, Jon K. Reel, Diane Stephenson, Yuan Su, Lisa A. Shipley, Celia A. Whitesitt, Tao Yin, James E. Audia   +59 more
openalex   +1 more source

Gamma-Secretase Inhibitor LY3039478 [PDF]

, 2020
openaire   +1 more source

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations. [PDF]

Int J Mol Sci, 2021
Kim M, Bezprozvanny I.
europepmc   +1 more source

P1‐136: The effect of gamma secretase inhibitors on modulating differentiation in human embryonic stem cell‐derived neural cells [PDF]

, 2008
Roxana Nat, Bengt Winblad, Helena Karlström   +2 more
openalex   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, Volume 604, Issue 4, Page 1646-1681, 15 February 2026.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

O4‐03–03: C‐terminal PAL motif of presenilin 1 comprises the subsite of gamma‐secretase within the catalytic pore [PDF]

, 2008
Taisuke Tomita, Chihiro Sato, Shizuka Takagi, Takeshi Iwatsubo   +3 more
openalex   +1 more source

Supplementary Table 2 from Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors

, 2023
Anne F. Schott, Melissa D. Landis, Gabriela Dontu, Kent A. Griffith, Rachel M. Layman, Ian E. Krop, Lacey A. Paskett, Helen Wong, Lacey E. Dobrolecki, Michael T. Lewis, Amber M. Froehlich, Jaya Paranilam, Daniel F. Hayes, Max S. Wicha, Jenny C. Chang   +14 more
openalex   +1 more source