Results 171 to 180 of about 8,778 (220)

Gammadelta T cells - innate immune lymphocytes?

Current opinion in immunology, 2007
It is unclear what the antigen recognition determinants of gammadelta T-cell receptors (TCRs) are. Compared with immunoglobulin and alphabeta TCRs, gammadelta TCRs have the highest potential CDR3 diversity generated by VDJ recombination. However, gammadelta T-cell reactivities seem to segregate with V gene usage, which has been taken to suggest that ...
Yves, Konigshofer, Yueh-hsiu, Chien
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Gammadelta T cells present antigen to CD4+ alphabeta T cells.

Journal of leukocyte biology, 1998
Gammadelta and alphabeta TCR+ T cells share many properties and their interactions are likely to be coordinated and regulated. We provide evidence that cattle gammadelta T cells are able to present antigen to CD4+ T cells. To help elucidate their function gammadelta T cell lines were propagated for extensive characterization.
R A, Collins, D, Werling, S E, Duggan, A P, Bland, K R, Parsons, C J, Howard   +5 more
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Anti-lymphoma effect of gammadelta T cells.

Leukemia & lymphoma, 2005
During the last few years, our knowledge about the activation and control of non-major histocompatibility complex (MHC)-restricted innate effector lymphocytes (such as natural killer (NK) cells, NK T cells and gammadelta T cells) has advanced enormously and immunotherapeutic strategies based on these cell types receive more and more attention.
Volker, Kunzmann, Martin, Wilhelm
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Function of intestinal gammadelta T cells.

Immunologic research, 2000
Mucosal tissues including the intestine, lung, reproductive tract, and skin form the major interfaces between the outside and internal milieus. Facing the outside is an epithelial cell layer, the epithelium, built on a vascular connective surface. In addition to performing specialized functions, mucosal tissues are sites where immune, epithelial, and ...
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gammadelta T cells in malaria infections.

Parasitology today (Personal ed.), 2005
The association of a pronounced gammadelta T-cell response with Plasmodium infections is intriguing. The ability of parasite material to activate gammadelta T cells in vitro, and the localization of these cells in vivo in the red pulp of the spleen, suggests that these cells could play a role in the killing of bloodstage malaria parasites. However, the
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Generation of human gammadelta T-cell repertoires.

Critical reviews in immunology, 2000
The nature of how the human gammadelta T-cell repertoire is generated during normal development is poorly understood. Unlike TCR -alphabeta+ cells that are almost exclusively dependent upon the thymus for their development and maturation, gammadelta T cells can be generated in extrathymic sites.
L D, McVay, S R, Carding
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Development and selection of gammadelta T cells.

Immunological reviews, 2007
Two main lineages of T cells develop in the thymus: those that express the alphabeta T-cell receptor (TCR) and those that express the gammadelta TCR. Whereas the development, selection, and peripheral localization of newly differentiated alphabeta T cells are understood in some detail, these processes are less well characterized in gammadelta T cells ...
Na, Xiong, David H, Raulet
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Cutaneous biology of gammadelta T cells.

Advances in dermatology, 2004
The vast majority of serious noninfectious skin diseases are the result of inappropriate inflammatory responses (eg, atopic dermatitis, psoriasis) or neoplastic transformation (eg, squamous cell carcinoma, melanoma, cutaneous T-cell lymphoma). T cells are critical to both of these major disease categories, playing critical roles in driving or ...
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Gammadelta T cells: functional plasticity and heterogeneity.

Nature reviews. Immunology, 2002
Gammadelta T cells remain an enigma. They are capable of generating more unique antigen receptors than alphabeta T cells and B cells combined, yet their repertoire of antigen receptors is dominated by specific subsets that recognize a limited number of antigens. A variety of sometimes conflicting effector functions have been ascribed to them, yet their
Carding, Simon R, Egan, Paul J
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gammadelta T-cell lymphomas: a homogeneous entity?

Histopathology, 2000
gammadelta T-cells comprise an immunologically distinct lymphoid population, characterized by specific morphological, phenotypical and functional properties. Therefore it seems reasonable to speculate that neoplasms derived from this particular T-cell subset display distinct features.
C, de Wolf-Peeters, R, Achten
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