Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells [PDF]
, 2017 Reactive arthritis (ReA) is an inflammatory condition of the joints that arises following an infection. Salmonella enterocolitis is one of the most common infections leading to ReA.
Aya Castañeda, Maria del Rosario +6 more
core +1 more source
Localized populations of CD8 MHC class I tetramer SIV-specific T cells in lymphoid follicles and genital epithelium. [PDF]
PLoS ONE, 2009 CD8 T cells play an important role in controlling viral infections. We investigated the in situ localization of simian immunodeficiency virus (SIV)-specific T cells in lymph and genital tissues from SIV-infected macaques using MHC-class I tetramers.
Jung Joo Hong +6 more
doaj +1 more source
Peripheral blood T-cell signatures from high-resolution immune phenotyping of γδ and αβ T-cells in younger and older subjects in the Berlin Aging Study II [PDF]
, 2015 Background Aging and latent infection with Cytomegalovirus (CMV) are thought to be major factors driving the immune system towards immunosenescence, primarily characterized by reduced amounts of naïve T-cells and increased memory T-cells, potentially ...
A Knight +52 more
core +2 more sources
Role of gammadelta T cells in protecting normal airway function
Respiratory Research, 2000 Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases.
Gelfand Erwin W +5 more
doaj +1 more source
Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours [PDF]
, 2016 Natural killer (NK) lymphocytes are part of the innate immune system and are important in immune protection against tumourigenesis. NK cells display a broad repertoire of activating and inhibitory cell surface receptors that regulate NK cell activity ...
Filtjens, Jessica +10 more
core +2 more sources
Lessons from helminth infections: ES-62 highlights new interventional approaches in rheumatoid arthritis [PDF]
, 2014 Parasitic worms are able to survive in their mammalian host for many years due to their ability to manipulate the immune response by secreting immunomodulatory products. It is increasingly clear that, reflecting the anti-inflammatory actions of such worm-
Al-Riyami, L. +3 more
core +1 more source
Skin- and gut-homing molecules on human circulating gamma delta T cells and their dysregulation in inflammatory bowel disease [PDF]
, 2012 Changes in phenotype and function of γδ T cells have been reported in inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC).
Al-Hassi, HO +12 more
core +1 more source
Frontiers in Immunology, 2020 Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment with a dense desmoplastic stroma. The expression of β-galactoside-binding protein galectin-3 is regarded as an intrinsic tumor escape mechanism for ...
Daniel Gonnermann +7 more
doaj +1 more source
Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer [PDF]
Investigative and Clinical Urology, 2019 Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy.
Marco Vella +7 more
doaj +1 more source
Pediatric Blood &Cancer, Volume 72, Issue 9, September 2025.ABSTRACT High‐risk neuroblastoma is a poor prognosis cancer of the sympathetic nervous system that accounts for a disproportionate number of childhood cancer deaths. Many viable biological targets have been identified, and the number of potential combinations is even larger.
Steven G. DuBois +44 more
wiley +1 more source