Results 61 to 70 of about 8,778 (220)

Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis.

open access: yesPLoS Pathogens, 2010
Differentiation, distribution and immune regulation of human IL-22-producing T cells in infections remain unknown. Here, we demonstrated in a nonhuman primate model that M.
Shuyu Yao   +6 more
doaj   +1 more source

Ontogeny of innate T lymphocytes - some innate lymphocytes are more innate then others

open access: yesFrontiers in Immunology, 2014
Innate lymphocytes have recently received a lot of attention. However, there are different ideas about the definition of what is innate in lymphocytes. Lymphocytes without V(D)J-rearranged antigen receptors are now termed innate lymphoid cells (ILCs) and
David eVermijlen, Immo ePrinz
doaj   +1 more source

γδ T Cells in Emerging Viral Infection: An Overview

open access: yesViruses, 2022
New emerging viruses belonging to the Coronaviridae, Flaviviridae, and Filoviridae families are serious threats to public health and represent a global concern.
Eleonora Cimini, Chiara Agrati
doaj   +1 more source

Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor

open access: yesCancer Communications, Volume 45, Issue 8, Page 888-913, August 2025.
Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai   +6 more
wiley   +1 more source

Gamma-delta (γδ) T cells: friend or foe in cancer development?

open access: yesJournal of Translational Medicine, 2018
Background γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity.
Yijing Zhao, Chao Niu, Jiuwei Cui
doaj   +1 more source

Differential Skewing of Circulating MR1-Restricted and γδ T Cells in Human Psoriasis Vulgaris

open access: yesFrontiers in Immunology, 2020
Psoriasis vulgaris (PV) is a chronic, recurrent inflammatory dermatosis mediated by aberrantly activated immune cells. The role of the innate-like T cells, particularly gammadelta T (γδT) cells and MR1-restricted T lymphocytes, is incompletely explored ...
Vera Plužarić   +11 more
doaj   +1 more source

Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells

open access: yesOncoImmunology, 2022
Ligands for Stimulator of Interferon Genes (STING) receptor are under investigation as adjuvants in cancer therapy. Multiple effects have been described, including induction of immunogenic cell death and enhancement of CD8 T-cell mediated anti-tumor ...
Ruben Serrano   +5 more
doaj   +1 more source

Harnessing the immunotherapeutic potentials of gamma delta T cells against hematological malignancies

open access: yesHemaSphere, Volume 9, Issue 8, August 2025.
Abstract Gamma delta (γδ) T cells, which constitute about 5%–10% of peripheral blood lymphocytes, play key roles in tumor immunosurveillance and are often enriched within epithelial tissues. They are unique in their Major Histocompatibility Complex‐independent antigen recognition via the γδ T‐cell receptor (TCR) as well as via innate receptors, making ...
Charles Agbuduwe   +2 more
wiley   +1 more source

Potential of gamma/delta T cells for solid tumor immunotherapy

open access: yesFrontiers in Immunology
Gamma/delta T (γδ T)cells possess a unique mechanism for killing tumors, making them highly promising and distinguished among various cell therapies for tumor treatment.
Dantong Zhu   +9 more
doaj   +1 more source

A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy

open access: yesFrontiers in Immunology, 2022
The γδT cell subset of peripheral lymphocytes exhibits potent cancer antigen recognition independent of classical peptide MHC complexes, making it an attractive candidate for allogeneic cancer adoptive immunotherapy.
Gabrielle M. Ferry   +7 more
doaj   +1 more source

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