Results 101 to 110 of about 10,381 (200)

A murine gammaherpesvirus.

Acta virologica, 2001
In 1976, within a project on isolation of herpesviruses from small rodents in former Czechoslovakia, the mouse herpesvirus strain 68 (MHV-68) was isolated (Blaskovic et al., 1980). This virus was accepted by The International Committee on Taxonomy of Viruses (ICTV) as a new, so far unassigned species (member) of the Gammaherpesvirinae subfamily of the ...
J, Mistríková, H, Raslová, M, Mrmusová, M, Kúdelová   +3 more
openaire   +1 more source

Endothelial Cells Support Persistent Gammaherpesvirus 68 Infection

PLoS Pathogens, 2008
A variety of human diseases are associated with gammaherpesviruses, including neoplasms of lymphocytes (e.g. Burkitt's lymphoma) and endothelial cells (e.g. Kaposi's sarcoma). Gammaherpesvirus infections usually result in either a productive lytic infection, characterized by expression of all viral genes and rapid cell lysis, or latent infection ...
Andrea Luísa Suárez, Linda Faye van Dyk   +1 more
openaire   +4 more sources

Visualizing Induction of Lytic Gammaherpesvirus Infection [PDF]

Retrovirology, 2005
EBV and KSHV both are associated with malignancies. In tumors the latent form of infection predominates and there is little or no expression of lytic genes. FIAU is a nucleoside analogue that is selectively phosphorylated by EBV and KSHV thymidine kinases. We have used a variety of pharmacologic agents to induce lytic infection in xenografts of Burkitt'
Ambinder Richard, Foss Catherine, Pomper Martin, Fu Dexue   +3 more
openaire   +2 more sources

Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment

Nature Communications
Gammaherpesviruses are DNA tumor viruses that establish lifelong latent infections in lymphocytes. For viruses such as Epstein-Barr virus and murine gammaherpesvirus 68, this is accomplished through a viral gene-expression program that promotes cellular ...
Shana M. Owens, Jeffrey M. Sifford, Gang Li, Steven J. Murdock, Eduardo Salinas, Darby Oldenburg, Debopam Ghosh, Jason S. Stumhofer, Intawat Nookaew, Mark Manzano, J. Craig Forrest   +10 more
doaj   +1 more source

Prognostic factors in bushfire‐affected koalas–Kangaroo Island bushfire response 2020

Australian Veterinary Journal, Volume 103, Issue 8, Page 453-463, August 2025.
This study presents a retrospective analysis of clinical records data from koalas presenting for treatment following the large‐scale bushfire event on Kangaroo Island 2019–2020. The aim of the study was to identify prognostic factors for koalas affected by bushfire. Koalas (n = 199) were grouped based on their burn status in combination with their burn
O Funnell, J McLelland, A Kokosinska, T Stephenson, E Dunstan, B Turner, N Speight   +6 more
wiley   +1 more source

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP [PDF]

, 2008
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Bienkowska-Szewczyk, Krystyna, Chowdhury, Shafiqul I., Daus, Franz, Heemskerk, Mirjam H. M., Koch, Joachim, Koppers-Lalic, Danijela, Lipinska, Andrea D., Loch, Sandra, Marcondes Rezende, Marisa, Mettenleiter, Thomas C., Neefjes, Jacques J., Osterrieder, Nikolaus, Quinten, Edwin, Reits, Eric A., Ressing, Maaike E., Rijsewijk, Frans A. M., Tampé, Robert, Verweij, Marieke C., Wang, Ying, Wiertz, Emmanuel J. H. J.   +19 more
core   +4 more sources

Role of the ubiquitin system and tumor viruses in AIDS-related cancer [PDF]

, 2007
Tumor viruses are linked to approximately 20% of human malignancies worldwide. This review focuses on examples of human oncogenic viruses that manipulate the ubiquitin system in a subset of viral malignancies; those associated with AIDS.
Julia Shackelford, Joseph S Pagano
core   +2 more sources

KSHV vIL6 Inhibits Functional B Cell Maturation During De Novo Infection

Journal of Medical Virology, Volume 97, Issue 7, July 2025.
ABSTRACT Despite causative links to lymphoproliferative disorders, little is known about early events governing KSHV infection in B lymphocytes. IL‐6 signaling plays a critical role in KSHV‐mediated disease, with human IL‐6 (hIL6) levels correlating with viral load and disease progression.
Wajd Zakir, Jessica M. Osborn, Jennifer E. Totonchy   +2 more
wiley   +1 more source

Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future [PDF]

, 2015
Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy.
CIRONE, Mara, FAGGIONI, Alberto, FARINA, Antonella, GONNELLA, ROBERTA, GRANATO, Marisa, SANTARELLI, Roberta, TRIVEDI, PANKAJ   +6 more
core   +9 more sources

PARP1 Inhibition Halts EBV+ Lymphoma Progression by Disrupting the EBNA2/MYC Axis

Journal of Medical Virology, Volume 97, Issue 7, July 2025.
ABSTRACT PARP1 has been shown to regulate EBV latency. However, the therapeutic effect of PARP1 inhibitors on EBV+ lymphomagenesis has not yet been explored. Here, we show that PARPi BMN 673 has a potent antitumor effect on EBV‐driven LCL in a mouse xenograft model. We found that PARP1 inhibition induces a dramatic transcriptional reprogramming of LCLs
Lisa Beatrice Caruso, Giorgia Napoletani, Samantha S. Soldan, Davide Maestri, Toshitha Kannan, Sarah Preston‐Alp, Peter Vogel, Andrew Kossenkov, Asher Sobotka, Paul M. Lieberman, Italo Tempera   +10 more
wiley   +1 more source