Results 11 to 20 of about 79,768 (305)

Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil [PDF]

PLoS Neglected Tropical Diseases, 2019
Zika virus infection is associated with the development of Guillain-Barré syndrome (GBS), a neurological autoimmune disorder caused by immune recognition of gangliosides and other components at nerve membranes.
Juan Rivera-Correa, I. D. de Siqueira, Sabrina Mota, M. D. do Rosário, Pedro Antonio Pereira de Jesus, L. Alcântara, J. Ernst, Ana Rodriguez   +7 more
semanticscholar   +3 more sources

Ganglioside Biochemistry [PDF]

ISRN Biochemistry, 2012
Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types.
T. Kolter
semanticscholar   +3 more sources

Mechanism of Secondary Ganglioside and Lipid Accumulation in Lysosomal Disease

International Journal of Molecular Sciences, 2020
Gangliosidoses are caused by monogenic defects of a specific hydrolase or an ancillary sphingolipid activator protein essential for a specific step in the catabolism of gangliosides.
Bernadette Breiden, K. Sandhoff
semanticscholar   +1 more source

Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping. [PDF]

PLoS ONE, 2012
Modified gangliosides may be overexpressed in certain types of cancer, thus, they are considered a valuable target in cancer immunotherapy. Structural knowledge of their interaction with antibodies is currently limited, due to the large size and high ...
Mark Agostino, Elizabeth Yuriev, Paul A Ramsland   +2 more
doaj   +1 more source

The ganglioside GD2 as a circulating tumor biomarker for neuroblastoma

Pediatric Blood & Cancer, 2020
GD2 is a ganglioside that is ubiquitously expressed in the plasma membrane of neuroblastoma and is shed into the circulation.
F. Balis, C. Busch, A. Desai, Emily Hibbitts, A. Naranjo, R. Bagatell, M. Irwin, E. Fox   +7 more
semanticscholar   +1 more source

Structural insights into Clostridium perfringens delta toxin pore formation [PDF]

, 2013
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
AGW Leslie, AH Nguyen, AJ McCoy, Ajit K. Basak, AL Keyburn, Andrea Motta, AP Heuck, AR Cole, B Geny, B Walker, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Potrich, CG Savva, Christos G. Savva, CL Hatheway, Claire E. Naylor, DC Briggs, DL Theobald, DL Theobald, E Krissinel, F Meyer, G Menestrina, J Huyet, J Rossjohn, JD Pedelacq, JD Thompson, JE Alouf, Jessica Huyet, JM Cavaillon, K Yamashita, L Jayasinghe, L Song, M Fivaz, M Manich, Maryse Gibert, MD Winn, Michel R. Popoff, N Monma, N Stein, O Knapp, P Emsley, P Evans, P Gouet, PV Afonine, R Olson, RK Tweten, S De, S Schwarz, S Sonnino, V Guillet, V Steinthorsdottir, VB Chen, VT Nguyen, Y Moran, Y Tanaka   +57 more
core   +17 more sources

Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Current immunotherapies only benefit a minority of all cancer patients, so it is necessary to develop other strategies to boost patients’ antitumor CD8+ T cell responses.
A. Affandi, Joanna Grabowska, Katarzyna Olesek, Miguel Lopez Venegas, Arnaud Barbaria, Ernesto Rodríguez, Patrick P. G. Mulder, Helen J. Pijffers, M. Ambrosini, H. Kalay, T. O’Toole, Eline S Zwart, G. Kazemier, K. Nazmi, F. Bikker, J. Stöckl, A. V. D. van den Eertwegh, T. D. de Gruijl, Gert Storm, Y. van Kooyk, J. D. den Haan   +20 more
semanticscholar   +1 more source

A Variant Guillain-Barré Syndrome with Anti-Ganglioside Complex Antibody [PDF]

Journal of Neurocritical Care, 2018
Background Recently, anti-ganglioside complex (GSC) antibodies were discovered among the various subtypes of Guillain-Barré syndrome. GSC is the novel glycoepitopes formed by two individual ganglioside molecules.
So-Young Huh, So-Young Lee, Jin-Hyung Lee, Won Gu Lee, Jong Kuk Kim, Byeol-A Yoon, Nam Jun Kim   +6 more
doaj   +1 more source

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis

Nature Communications, 2022
Progranulin-deficieny results in gangliosidosis due to reduced lysosomal lipids (BMP) required for ganglioside degradation. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD.
Sebastian Boland, Sharan Swarup, Yohannes A. Ambaw, Pedro C. Malia, Ruth C. Richards, Alexander W. Fischer, Shubham Singh, Geetika Aggarwal, Salvatore Spina, Alissa L. Nana, Lea T. Grinberg, William W. Seeley, Michal A. Surma, Christian Klose, Joao A. Paulo, Andrew D. Nguyen, J. Wade Harper, Tobias C. Walther, Robert V. Farese   +18 more
doaj   +1 more source

Structural basis of tetanus toxin neutralization by native human monoclonal antibodies

Cell Reports, 2021
Summary: Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 mg to 6 mg each that are equivalent to 250 IU of human anti-TeNT ...
Yueming Wang, Changwen Wu, Jinfang Yu, Shujian Lin, Tong Liu, Lipeng Zan, Nan Li, Po Hong, Xiaoli Wang, Zhenxing Jia, Jason Li, Yao Wang, Ming Zhang, Xiaohui Yuan, Chengming Li, Wenwen Xu, Weihong Zheng, Xinquan Wang, Hua-Xin Liao   +18 more
doaj   +1 more source