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Gangliosides as Immunomodulators
2007Gangliosides are glycosphingolipids expressed at the outer leaflet of the plasmatic membrane of cells from vertebrate organisms. These molecules exert diverse biological functions including modulation of the immune system responses. Aberrant expression of gangliosides has been demonstrated on malignant cells. Besides expression on tumor cell membranes,
Miroslava, Potapenko +2 more
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Drugs, 1994
Gangliosides are normal constituent of mammalian vertebrate cell membranes and are particularly abundant in the central and peripheral nervous systems. The biological effects of exogenously administered gangliosides have been extensively investigated in vitro and in experimental animal models where they have neuronotrophic and neuritogenic properties ...
E. Nobile-Orazio, M. Carpo, G. Scarlato
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Gangliosides are normal constituent of mammalian vertebrate cell membranes and are particularly abundant in the central and peripheral nervous systems. The biological effects of exogenously administered gangliosides have been extensively investigated in vitro and in experimental animal models where they have neuronotrophic and neuritogenic properties ...
E. Nobile-Orazio, M. Carpo, G. Scarlato
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New England Journal of Medicine, 1971
For almost 100 years Tay-Sachs disease was the only ganglioside storage disease known. A second inborn error of ganglioside metabolism, generalized gangliosidosis, was discovered in 1965.13,35 Three additional ganglioside storage diseases have recently been uncovered,4,3,52,66,74 bringing the total to five.36 Of these, three involve storage of ...
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For almost 100 years Tay-Sachs disease was the only ganglioside storage disease known. A second inborn error of ganglioside metabolism, generalized gangliosidosis, was discovered in 1965.13,35 Three additional ganglioside storage diseases have recently been uncovered,4,3,52,66,74 bringing the total to five.36 Of these, three involve storage of ...
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GANGLIOSIDES IN THE NERVOUS SYSTEM
Neurochemistry International, 1983Gangliosides, sialic acid-containing glycosphingolipids, are embedded in neural plasma membranes to provide cell surface recognition sites with negative charges. Exogenous ligands such as bacterial toxins, hormones, growth factors, antibodies, viruses, and interferons bind to specific gangliosides to induce sequential activations of cellular ...
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2019
Gangliosides comprise a varied family of glycosphingolipid structures bearing one or more sialic acid residues. They are found in all mammalian tissues but are most abundant in the brain, where they represent the quantitatively major class of sialoglycans.
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Gangliosides comprise a varied family of glycosphingolipid structures bearing one or more sialic acid residues. They are found in all mammalian tissues but are most abundant in the brain, where they represent the quantitatively major class of sialoglycans.
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Gangliosides and Cell Surface Ganglioside Glycohydrolases in the Nervous System
2014Gangliosides are a large group of complex lipids found predominantly on the outer layer of the plasma membranes of cells, and they are particularly concentrated in nerve endings. Their half-life in the nervous system is short, and their membrane composition and content are strictly connected to their metabolism.
M. Aureli +7 more
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2000
Abstract Gangliosides are sialic acid-containing glycosphingolipids primarily found in the plasma membrane of virtually all vertebrate tissues, with particular abundance in the nervous system. A mixture of purified bovine brain gangliosides has been used for the treatment of alcoholic, diabetic, and uremic polyneuropathy; after ...
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Abstract Gangliosides are sialic acid-containing glycosphingolipids primarily found in the plasma membrane of virtually all vertebrate tissues, with particular abundance in the nervous system. A mixture of purified bovine brain gangliosides has been used for the treatment of alcoholic, diabetic, and uremic polyneuropathy; after ...
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The multi-tasked life of GM1 ganglioside, a true factotum of nature.
TIBS -Trends in Biochemical Sciences. Regular ed, 2015R. Ledeen, Gusheng Wu
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GM1 Ganglioside: Past Studies and Future Potential
Molecular Neurobiology, 2015M. Aureli +6 more
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