Results 31 to 40 of about 79,768 (305)
Journal of Lipid Research, 1972 The galactose oxidase–sodium borohydride method was used to specifically label the terminal N-acetylgalactosamine of three glycosphingolipids, Gm2-ganglioside, asialo-Gm2-ganglioside, and globoside.
Yoshiyuki Suzuki, Kunihiko Suzuki
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Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy
Frontiers in Oncology, 2020 Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in normal tissues, making most subtypes unsuitable as targets for cancer therapy. However, the disialoganglioside GD2 subtype has limited expression in normal tissues but is
Bassel Nazha +2 more
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Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene
FEBS Open Bio, 2023 Genetic disruption of glycosyltransferases has provided clear information on the roles of their reaction products in the body. Our group has studied the function of glycosphingolipids by genetic engineering of glycosyltransferases in cell culture and in ...
Koichi Furukawa +5 more
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PLoS ONE, 2018 Reduced expression of GM1 and other major brain gangliosides GD1a, GD1b and GT1b have been reported in Parkinson’s disease (PD) brain. Mechanisms underlying these changes are unclear but may be due to a deficit in the ganglioside biosynthetic process ...
J. Schneider
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Emerging concepts of ganglioside metabolism
FEBS Letters, 2018 Gangliosides (GGs) are sialic acid‐containing glycosphingolipids (GSLs) and major membrane components enriched on cellular surfaces. Biosynthesis of mammalian GGs starts at the cytosolic leaflet of endoplasmic reticulum (ER) membranes with the formation ...
R. Sandhoff, K. Sandhoff
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Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals [PDF]
, 2011 Objectives: Anti-ganglioside antibodies are present in approximately half of Guillain–Barré syndrome (GBS) patients. Recently, it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a
Goodfellow +22 more
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O-acetylated Gangliosides as Targets for Cancer Immunotherapy
Cells, 2020 O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities.
Sumeyye Cavdarli +2 more
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Biology of GD2 ganglioside: implications for cancer immunotherapy
Frontiers in Pharmacology, 2023 Part of the broader glycosphingolipid family, gangliosides are composed of a ceramide bound to a sialic acid-containing glycan chain, and locate at the plasma membrane.
Pierre Machy +2 more
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Journal of Physical Chemistry B, 2016 Gangliosides are glycolipids in which an oligosaccharide headgroup containing one or more sialic acids is connected to a ceramide. Gangliosides reside in the outer leaflet of the plasma membrane and play a crucial role in various physiological processes ...
Ruo-Xu Gu +4 more
semanticscholar +1 more source
Immune Response Modulation by Tumor-Secreted Glycosphingolipids [PDF]
, 2014 Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) arenow recognized as having critical effects on cellular physiology, including proliferation, differentiation, viraltransformation and ontogenesis.
Cely, Ingrid +3 more
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