Results 71 to 80 of about 21,456 (123)
Alkaline Phosphatase and Infantile GM1 Gangliosidosis: A Simple Biomarker for a Complex Disease?
JIMD Reports, Volume 67, Issue 2, March 2026.ABSTRACT GM1 gangliosidosis is a lysosomal storage disease (LSD) caused by β‐galactosidase deficiency, characterized by the accumulation of gangliosides in various tissues. Among different GM1 forms (infantile form, late‐infantile and juvenile form, and late‐onset form), the infantile form is the most severe: despite an early clinical onset with rapid ...
Laura Fiori +19 more
wiley +1 more source
Early Cancer Detection: What's Going on and What's Next
MedComm, Volume 7, Issue 3, March 2026.Multicancer early detection (MCED) platforms have emerged as a promising strategy for the safe and effective early detection of multiple cancer types, with the potential to reduce metastatic burden and improve clinical outcomes, particularly for aggressive malignancies that lack effective population‐level screening.
Emma Di Carlo
wiley +1 more source
Molecular Nutrition &Food Research, Volume 70, Issue 6, 29 March 2026.Lipid and food structure determine when and how macro‐ and micronutrients become bioaccessible. This review compares lipid bioaccessibility from engineered emulsions, breast milk, infant formula, and meat and meat mimics, which couples the effect of cooking temperature on lipid bioaccessibility in meat and eggs. ABSTRACT Food structure has emerged as a
Michael A. Rogers, Amanda J. Wright
wiley +1 more source
Langat Virus Biology and Infection
Reviews in Medical Virology, Volume 36, Issue 2, March 2026.ABSTRACT Flaviviruses pose a major threat to global health and can cause severe disease in animals and humans. Among them, tick‐borne encephalitis virus (TBEV) and related members of the tick‐borne encephalitis (TBE) serocomplex are transmitted primarily by ticks and can lead to neurological disease, including encephalitis and death. Despite many years
Zinaida Klestova +3 more
wiley +1 more source
Aging Cell, Volume 25, Issue 3, March 2026.Drosophila and mouse models of Alzheimer's disease exhibit lipid accumulation and neuroinflammation, leading to progressive impairments in memory, locomotion, sleep, circadian rhythms, and synaptic integrity. Knockdown of Dgat2 reduces lipid accumulation and neuroinflammatory signaling, rescuing these deficits and highlighting a conserved, crossspecies
Archana Yadav +7 more
wiley +1 more source
Structural and functional glycosphingolipidomics by glycoblotting with aminooxy-functionalized gold nanoparticle [PDF]
, 2008 Glycosphingolipids (GSLs) synthesized in Golgi apparatus by sequential transfer of sugar residues to a ceramide lipid anchor are ubiquitously distributing on vertebrate plasma membranes.
Midori Abe +2 more
core +1 more source
Sialylation patterns in cerebral amyloid angiopathy
Brain Pathology, Volume 36, Issue 2, March 2026.This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau +8 more
wiley +1 more source
Journal of Neurochemistry, Volume 170, Issue 3, March 2026.The study investigates the functional consequences of INTS11 loss‐of‐function (LoF), a genetic alteration linked to neurodevelopmental disorder (NDD), using zebrafish as an in vivo model. To model ints11 deficiency, two complementary approaches are applied: morpholino‐mediated knock‐down and CRISPR–Cas9 transient knock‐out, establishing ints11‐LoF ...
Anna Pistocchi +9 more
wiley +1 more source
The Application of PD‐1 Inhibitors in Immunotherapy for Glioblastoma
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.The molecular mechanism of PD‐1. When PD‐1 binds to PD‐L1, the ITIM and ITSM domains within PD‐1 are phosphorylated and subsequently recruit SHP‐2. This then dephosphorylates downstream molecules of the TCR, such as PI3K/AKT and ZAP70, reduces the secretion of IFN‐γ, and inhibits the presentation of antigens to T cells via MHC molecules through the ...
Ming‐zhen Dong +4 more
wiley +1 more source