Results 81 to 90 of about 19,645 (254)

Anti‐GD1b Disorder Presenting as Multiple Mononeuropathies

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Isolated anti GD1b disorders are quite rare. They usually present with ophthalmoplegia, sensory ataxia, paraproteinemia, and elevated cold agglutinants. The response to immunosuppressant treatment does not seem to be very effective. We report a case of isolated mononeuropathies associated with isolated anti‐GD1b antibodies, without ataxia or ...
Kamar Eid, Rim Araoui, Ragheb Ismail, Raja Sawaya   +3 more
wiley   +1 more source

Brain Alterations Linked to the MPTP Mouse Model of Parkinson's Disease Uncovered by Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
In MPTP‐treated mice, DKI and 1H‐MRS revealed increased hippocampal and thalamic diffusivity with reduced striatal Glu/tCr and Glx/tCr at 24 h. By 72 h, cortical, striatal, and thalamic diffusivity rose, with partial hippocampal recovery. Elevated Tau/tCr and hippocampal metabolite alterations paralleled neuronal loss and gliosis, supporting DKI/1H‐MRS
Ajay Modi, Sheetal Maria, Jana Ruda‐Kucerova, Eva Drazanova, Iveta Harastova‐Pavlova, Alzbeta Sejnoha Minsterova, Kristina Kovacovicova, Daniel Havas, Irena Rektorova, Tiago F. Outeiro, Amit Khairnar   +10 more
wiley   +1 more source

PREDICTOR: A Non‐Enzymatic Catalytic Cascade Tool for in Situ Visualization of Small Extracellular Vesicle Surface glycoRNAs

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
PREDICTOR, a non‐enzymatic catalytic circuit for imaging trace glycoRNAs on sEVs, reveals that glycoRNAs abundance negatively correlates with tumour malignancy and is functionally important for sEVs uptake by macrophages ABSTRACT Glycosylated RNAs (glycoRNAs) are membrane‐displayed RNA‐glycan conjugates, but quantitative in situ analysis of low ...
Shuang Xie, Ben Niu, Ruijia Deng, Liu Feng, Zuowei Xie, Shuang Zhao, Hongzhao Yang, Meilin Gong, Jing Sheng, Ligai Zhang, Yan Pi, Ningtao Cheng, Ming Chen, Kai Chang   +13 more
wiley   +1 more source

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination [PDF]

, 2017
Effective bidirectional signalling between axons and Schwann cells is essential for both the development and maintenance of peripheral nerve function. We have established conditions by which human induced pluripotent stem cell-derived sensory neurons can
Bennett, David L.H., Clark, Alex J., Galino, Jorge, Kaller, Malte S., Rinaldi, Simon, Willison, Hugh J.   +5 more
core   +2 more sources

Effects of cyclodextrins on GM1-gangliosides in fibroblasts from GM1-gangliosidosis patients

Journal of Pharmacy and Pharmacology, 2015
Abstract Objectives GM1-gangliosidosis is an inherited disorder characterized by the accumulation of GM1-gangliosides in many tissues and organs, particularly in the brain. Currently, there is no treatment available for patients with ganglioside storage diseases. Therefore, we investigated the effects
Yuki, Maeda, Keiichi, Motoyama, Taishi, Higashi, Yuka, Horikoshi, Toru, Takeo, Naomi, Nakagata, Yuki, Kurauchi, Hiroshi, Katsuki, Yoichi, Ishitsuka, Yuki, Kondo, Tetsumi, Irie, Hirokazu, Furuya, Takumi, Era, Hidetoshi, Arima   +13 more
openaire   +2 more sources

Pyridostigmine Treatment for Pediatric Axonal Guillain–Barré Syndrome

Muscle &Nerve, Volume 73, Issue 4, Page 655-662, April 2026.
ABSTRACT Introduction/Aims Direct involvement of the neuromuscular junction (NMJ) in the inflammatory process of Guillain–Barré syndrome (GBS) has been described. Despite this, the NMJ very rarely serves as a target for direct medical intervention in GBS.
E. Zohar‐Dayan, J. Landa, S. Barak, B. Ben‐Zeev   +3 more
wiley   +1 more source

From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [PDF]

, 2009
Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine moiety have ...
André, Sabine, Gabius, Hans-Joachim, Kojima, Shuji, Kozar, Tibor, Unverzagt, Carlo   +4 more
core   +1 more source

Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry

PROTEOMICS, Volume 26, Issue 4, Page 7-22, April 2026.
ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu, Shuling Xu, Penghsuan Huang, Lingjun Li   +3 more
wiley   +1 more source

Role of Membrane GM1 on Early Neuronal Membrane Actions of Aβ During Onset of Alzheimer\u27s Disease [PDF]

, 2017
The ability of beta-amyloid peptide (Aβ) to disrupt the plasma membrane through formation of pores and membrane breakage has been previously described. However, the molecular determinants for these effects are largely unknown.
Aguayo, Luis G., Fernandez-Perez, E. J., Peoples, Robert W., Sepulveda, Fernando   +3 more
core   +1 more source