Results 101 to 110 of about 19,645 (254)

The Third Dimension of Reading the Sugar Code by Lectins [PDF]

, 2013
Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages ...
André, Sabine, Gabius, Hans-Joachim, Murphy, Paul V.   +2 more
core   +3 more sources

The Differential Diagnosis of Coma in the ICU: Hyperacute Postoperative Guillain‐Barré Syndrome—A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Guillain‐Barré syndrome (GBS) is a rare, immune‐mediated neurological disorder that can be challenging to diagnose in postoperative patients due to atypical manifestations and overlapping conditions. This case report highlights the diagnostic and therapeutic challenges of GBS following vascular surgery. We present the case of a 56‐year‐old man
Miron Tiganas, Abdulrahman Ismaiel, Dan Sebastian Dirzu, Iris Aszalos   +3 more
wiley   +1 more source

Manipulation of lipid rafts in neuronal cells [PDF]

, 2010
Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
core   +1 more source

A modular chemoenzymatic cascade strategy for the structure-customized assembly of ganglioside analogs

Communications Chemistry
Gangliosides play vital biological regulatory roles and are associated with neurological system diseases, malignancies, and immune deficiencies. They have received extensive attention in developing targeted drugs and diagnostic markers.
Xuefeng Jin, Hanchao Cheng, Xiaohui Chen, Xuefeng Cao, Cong Xiao, Fengling Ding, Huirong Qu, Peng George Wang, Yan Feng, Guang-Yu Yang   +9 more
doaj   +1 more source

Gangliosides: Treatment Avenues in Neurodegenerative Disease

Frontiers in Neurology, 2019
Gangliosides are cell membrane components, most abundantly in the central nervous system (CNS) where they exert among others neuro-protective and -restorative functions.
Pierre J. Magistretti, Pierre J. Magistretti, Pierre J. Magistretti, Fred H. Geisler, Jay S. Schneider, P. Andy Li, Hubert Fiumelli, Hubert Fiumelli, Hubert Fiumelli, Simonetta Sipione   +9 more
doaj   +1 more source

Properties of ganglioside GM1 in phosphatidylcholine bilayer membranes

Biophysical Journal, 1996
Gangliosides have been shown to function as cell surface receptors, as well as participating in cell growth, differentiation, and transformation. In spite of their multiple biological functions, relatively little is known about their structure and physical properties in membrane systems.
Reed, R.A., Shipley, G.G.
openaire   +2 more sources

Generation of an infantile GM1 gangliosidosis induced pluripotent stem cell line (CHOCi005-A) for disease modeling and therapeutic testing

Stem Cell Research
GM1 gangliosidosis (GM1) is a rare autosomal recessive neurogenerative lysosomal storage disease characterized by deficiency of beta-galactosidase (β-gal) and intralysosomal accumulation of GM1 ganglioside and other glycoconjugates.
Allisandra K. Rha, Chloe L. Christensen, Shih-Hsin Kan, Jerry F. Harb, Perla Andrade-Heckman, Raymond Y. Wang   +5 more
doaj   +1 more source

Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts [PDF]

, 2019
Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with saturated ...
Antollini, Silvia Susana, Fabiani, Camila   +1 more
core   +1 more source

Impaired levels of gangliosides in the Corpus Callosum of Huntington Disease animal models

Frontiers in Neuroscience, 2016
Huntington Disease (HD) is a genetic neurodegenerative disorder characterized by broad types of cellular and molecular dysfunctions that may affect both neuronal and non-neuronal cell populations. Among all the molecular mechanisms underlying the complex
Alba Di Pardo, Enrico Amico, Vittorio Maglione   +2 more
doaj   +1 more source

Effect of serum on ganglioside uptake and choleragen responsiveness of transformed mouse fibroblasts

Journal of Lipid Research, 1978
NCTC 2071 cells, transformed mouse fibroblasts, did not respond to choleragen when grown in chemically defined medium. When grown in medium containing 10% fetal calf serum, however, the cells accumulated cyclic AMP upon exposure to the toxin ...
P H Fishman, R M Bradley, J Moss, V C Manganiello   +3 more
doaj   +1 more source