Results 121 to 130 of about 19,645 (254)

GM1 ganglioside in Parkinson\u27s disease: Pilot study of effects on dopamine transporter binding. [PDF]

, 2015
OBJECTIVE: GM1 ganglioside has been suggested as a treatment for Parkinson\u27s disease (PD), potentially having symptomatic and disease modifying effects.
Brašić, James R., Cambi, Franca, Gollomp, Stephen M., Kuwabara, Hiroto, Leiby, Benjamin E., Schneider, Jay S., Sendek, Stephanie, Wong, Dean F.   +7 more
core   +1 more source

Water response to ganglioside GM1 surface remodelling

Biochimica et Biophysica Acta (BBA) - General Subjects, 2017
Gangliosides are biological glycolipids participating in rafts, structural and functional domains of cell membranes. Their headgroups are able to assume different conformations when packed on the surface of an aggregate, more lying or standing. Switching between different conformations is possible, and is a collective event.
P. Brocca, V. Rondelli, F. Mallamace, M. T. Di Bari, A. Deriu, W. Lohstroh, E. Del Favero, M. Corti, L. Cantù   +8 more
openaire   +3 more sources

Structure of Galectin-3 bound to a model membrane containing ganglioside GM1. [PDF]

Biophys J, 2023
Vander Zanden CM, Majewski J, Weissbarth Y, Browne DF, Watkins EB, Gabius HJ.   +5 more
europepmc   +1 more source

Conduction block in acute motor axonal neuropathy [PDF]

, 2017
Guillain-Barré syndrome is divided into two major subtypes, acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. The characteristic electrophysiological features of acute motor axonal neuropathy are reduced amplitude or ...
Hirata, Koichi, Kokubun, Norito, Nishibayashi, Momoka, Odaka, Masaaki, Uncini, Antonino, Yuki, Nobuhiro   +5 more
core  

Peripheral Delivery of Ganglioside GM1 Exacerbates the Pathogenesis of Alzheimer's Disease in a Mouse Model. [PDF]

Neurosci Bull, 2022
Yang CC, Cheng Y, Yang HM, Chen Y, Wang YJ, Xu ZQ, Wang YR.   +6 more
europepmc   +1 more source

Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model

Cell Reports
Summary: Endoplasmic reticulum-plasma membrane (ER-PM) junctions mediate Ca2+ flux across neuronal membranes. The properties of these membrane contact sites are defined by their lipid content, but little attention has been given to glycosphingolipids ...
Jason A. Weesner, Ida Annunziata, Diantha van de Vlekkert, Camenzind G. Robinson, Yvan Campos, Ashutosh Mishra, Leigh E. Fremuth, Elida Gomero, Huimin Hu, Alessandra d’Azzo   +9 more
doaj   +1 more source

Binding of Cholera Toxin B-Subunit to a Ganglioside GM1-Functionalized PEG-Tethered Lipid Membrane. [PDF]

Langmuir, 2022
Watkins EB, Dennison AJC, Majewski J.
europepmc   +1 more source

GM1 - gangliosidosis in a Nigerian infant: A case report

Nigerian Journal of Paediatrics, 2021
Gangliosidoses belong to the group of genetic lipid metabolism disorders, caused by defects of lysosome enzymes, inherited as an autosomal recessive trait. Gangliosidosis GM1 is caused by the deficiency of the acid beta galactosidase (GLB11) resulting in
Abdullahi M Sakina, Idris W Hafsat Hafsat, Sadiku A Halima, Abubakar El - ishaq   +3 more
doaj  

Myelin basic protein peptide 45–89 induces the release of nitric oxide from microglial cells.

, 2002
Continuous (24 h) exposure of mixed oligodendrocyte/microglial cells to peptides 45–89 derived from citrullinated C8 isoforms of myelin basic protein (MBP) induces cell death.
Machaidze, G., Mikeladze, D., Pichkhadze, B., Ramsden, Jeremy J., Shanshiashvili, L.   +4 more
core  

Identification of GM1-Ganglioside Secondary Accumulation in Fibroblasts from Neuropathic Gaucher Patients and Effect of a Trivalent Trihydroxypiperidine Iminosugar Compound on Its Storage Reduction

Molecules
Gaucher disease (GD) is a rare genetic metabolic disorder characterized by a dysfunction of the lysosomal glycoside hydrolase glucocerebrosidase (GCase) due to mutations in the gene GBA1, leading to the cellular accumulation of glucosylceramide (GlcCer).
Costanza Ceni, Francesca Clemente, Francesca Mangiavacchi, Camilla Matassini, Rodolfo Tonin, Anna Caciotti, Federica Feo, Domenico Coviello, Amelia Morrone, Francesca Cardona, Martino Calamai   +10 more
doaj   +1 more source